Methyl2-chloro-5-fluoronicotinate
- CAS No.
- 847729-27-5
- Chemical Name:
- Methyl2-chloro-5-fluoronicotinate
- Synonyms
- 136438;Methyl2-chloro-5-fluoronicotinate;2-Chloro-5-fluoro-nicotinic acid Methyl ester;methyl 2-chloro-5-fluoropyridine-3-carboxylate;2-chloro-5-fluoro-3-pyridinecarboxylic acid methyl ester;3-Pyridinecarboxylic acid, 2-chloro-5-fluoro-, methyl ester
- CBNumber:
- CB11229337
- Molecular Formula:
- C7H5ClFNO2
- Molecular Weight:
- 189.57
- MDL Number:
- MFCD09763661
- MOL File:
- 847729-27-5.mol
- MSDS File:
- SDS
| Boiling point | 235.4±40.0 °C(Predicted) |
|---|---|
| Density | 1.386±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | solid |
| pka | -3.73±0.10(Predicted) |
| InChI | 1S/C7H5ClFNO2/c1-12-7(11)5-2-4(9)3-10-6(5)8/h2-3H,1H3 |
| InChIKey | VYUNQTNDEVFXPO-UHFFFAOYSA-N |
| SMILES | COC(=O)c1cc(F)cnc1Cl |
| CAS DataBase Reference | 847729-27-5 |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P260-P280-P312 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 22 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
| Storage Class | 11 - Combustible Solids |
Methyl2-chloro-5-fluoronicotinate price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ADE000416 | Methyl 2-chloro-5-fluoronicotinate Aldrich | 847729-27-5 | 1g | $586 | 2026-04-30 | Buy |
| Apolloscientific | PC200135 | Methyl 2-chloro-5-fluoronicotinate >98% | 847729-27-5 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC200135 | Methyl 2-chloro-5-fluoronicotinate >98% | 847729-27-5 | 5g | $25 | 2026-06-04 | Buy |
| Apolloscientific | PC200135 | Methyl 2-chloro-5-fluoronicotinate >98% | 847729-27-5 | 25g | $116 | 2026-06-04 | Buy |
| Apolloscientific | PC200135 | Methyl 2-chloro-5-fluoronicotinate >98% | 847729-27-5 | 100g | $460 | 2026-06-04 | Buy |
Methyl2-chloro-5-fluoronicotinate Chemical Properties, Uses, Production
Uses
Methyl 2-chloro-5-fluoronicotinate
Synthesis
38186-88-8
18107-18-1
847729-27-5
Example 58 Synthesis of 4-((5-fluoro-2-(4-fluorophenyl)pyridin-3-yl]methyl}amino)methylbenzoic acid Procedure 1. Preparation of methyl 5-fluoro-2-(4-fluorophenyl)nicotinate: 2-chloro-5-fluoronicotinic acid (1.00 g, 5.70 mmol) was dissolved in a mixture of solvents of methanol (4 mL) and dichloromethane (14 mL) at 0 °C, and slowly added to a 2M hexane solution of trimethylsilylated diazomethane (5.70 mL, 11.4 mmol). The reaction mixture was stirred at 0 °C for 1 hour. Upon completion of the reaction, the reaction was quenched with acetic acid and the solvent was removed by concentration under reduced pressure. The residue was purified by fast column chromatography on silica gel using hexane/ethyl acetate (10:1, v/v) as eluent to afford 0.78 g (72% yield) of methyl 2-chloro-5-fluoronicotinate as a colorless oil. The product was characterized by 1H-NMR (CDCl3): δ 8.41 (1H, d, J=3.1 Hz), 7.93 (1H, dd, J=7.6,3.1 Hz), 3.98 (3H, s).
References
[1] Patent: WO2005/21508, 2005, A1. Location in patent: Page/Page column 97
[2] Patent: WO2005/102389, 2005, A2. Location in patent: Page/Page column 142-143
Methyl2-chloro-5-fluoronicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Shanghai Hong-chuang Pharma Tech Co., Ltd. | 18151128828 | hc-sales@foxmail.com | China | 2635 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Qinghang Chemical Co. Ltd. | 021-50840321, 18601625411 | thomasleehz@hotmail.com | China | 216 | 50 |
| Nantong Zandery Biotechnology Co., Ltd. | 0513-87582998 13912206938 | xiaofeizhu@vip.163.com | China | 272 | 55 |
| NovoChemy Ltd. | 86-(0)21-31261262 373522135 | sales@novochemy.com | China | 6491 | 58 |
View Latest Price from Methyl2-chloro-5-fluoronicotinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-10 | METHYL2-CHLORO-5-FLUORONICOTINATE
847729-27-5
|
$6.00 | 1KG | 98% | 1kg, 5kg, 50kg | Career Henan Chemical Co |
-
- METHYL2-CHLORO-5-FLUORONICOTINATE
847729-27-5
- $6.00
- 98%
- Career Henan Chemical Co
