(Trimethylsilyl)diazomethane
- CAS No.
- 18107-18-1
- Chemical Name:
- (Trimethylsilyl)diazomethane
- Synonyms
- TMSCHN2;TMSCH2N2;(DIAZOMETHYL)TRIMETHYLSILANE;TMS-DIAZOMETHANE;(trimethylsilyl)diazomethanesolution;2.0 M in hexanes;ACROS Organics™TriMethylsilyl)diazoMethan;iazomethyl(trimethyl)silane;Diazo(trimethylsilyl)methane
- CBNumber:
- CB9432840
- Molecular Formula:
- C4H10N2Si
- Molecular Weight:
- 114.22
- MDL Number:
- MFCD00053946
- MOL File:
- 18107-18-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 96 °C |
|---|---|
| Density | 0.773 g/mL at 25 °C |
| refractive index | 1.4362 |
| Flash point | −31 °F |
| storage temp. | Refrigerator |
| solubility | Sol most organic solvents; insol H2O. |
| form | Solution |
| color | White |
| Water Solubility | Immiscible with water. Miscible with organic solvents. |
| Sensitive | Moisture & Light Sensitive |
| BRN | 1902903 |
| Stability | Shock Sensitive |
| InChI | InChI=1S/C4H10N2Si/c1-7(2,3)4-6-5/h4H,1-3H3 |
| InChIKey | ONDSBJMLAHVLMI-UHFFFAOYSA-N |
| SMILES | C(=[N+]=[N-])[Si](C)(C)C |
| CAS DataBase Reference | 18107-18-1(CAS DataBase Reference) |
| FDA UNII | QI98HQO8C4 |
| EPA Substance Registry System | Silane, (diazomethyl)trimethyl- (18107-18-1) |
| UNSPSC Code | 12352302 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS02,GHS06,GHS08,GHS09 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H331-H361-H225-H304-H315-H330-H336-H350-H361f-H370-H373-H411-H302 | |||||||||
| Precautionary statements | P201-P210-P280-P308+P311-P370+P378-P403+P235-P260-P301+P310a-P303+P361+P353-P405-P501a | |||||||||
| target organs | Central nervous system, Lungs | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | F+,Xn,N,F,T,T+ | |||||||||
| Risk Statements | 12-19-22-66-67-65-62-51/53-48/20-38-11-23-39/26-26-45 | |||||||||
| Safety Statements | 9-16-29-33-36/37-61-62-45-28-53 | |||||||||
| RIDADR | UN 1208 3/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29270000 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 2 Inhalation Acute Tox. 4 Oral Carc. 1B Flam. Liq. 2 STOT SE 1 Inhalation STOT SE 3 |
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| Hazardous Substances Data | 18107-18-1(Hazardous Substances Data) | |||||||||
| Limited Quantities | 1.0 L (0.3 gallon) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
(Trimethylsilyl)diazomethane price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T1146 | Trimethylsilyldiazomethane (ca. 10% in Hexane, ca. 0.6mol/L) | 18107-18-1 | 10mL | $85 | 2026-04-30 | Buy |
| TCI Chemical | T1146 | Trimethylsilyldiazomethane (ca. 10% in Hexane, ca. 0.6mol/L) | 18107-18-1 | 25mL | $170 | 2026-04-30 | Buy |
| Chem-Impex | 42395 | Trimethylsilyldiazomethane (ca. 10% in Hexane, ca. 0.6mol/L) ≥10%(NMR) | 18107-18-1 | 10ML | $135 | 2026-05-19 | Buy |
| Chem-Impex | 42395 | Trimethylsilyldiazomethane (ca. 10% in Hexane, ca. 0.6mol/L) ≥10%(NMR) | 18107-18-1 | 25ML | $260 | 2026-05-19 | Buy |
| Chem-Impex | 42395 | Trimethylsilyldiazomethane (ca. 10% in Hexane, ca. 0.6mol/L) ≥10%(NMR) | 18107-18-1 | 100ML | $850 | 2026-05-19 | Buy |
(Trimethylsilyl)diazomethane Chemical Properties, Uses, Production
Chemical Properties
clear yellow solution
Physical properties
bp 96 °C/775 mmHg; nD/25 1.4362.2
Uses
Reactant for preparation of: &bull Macrolactam analogs of the natural product macrolide (-)-A26771B with improved metabolic stability and antibacterial activity &bull Aigialomycin D analogues as protein kinase inhibitors for cancer treatment &bull Unnatural α-amino acid derivatives containing gem-bisphosphonates via Michael addition reaction &bull Capped 4-methylumbelliferyl hyaluronan disaccharides and tetrasaccharides as potential hyaluronidase substrates &bull Stictamides A-C as matrix metallopeptidase 12 (MMP12) inhibitors with antitumor invasion activity &bull Endothelin converting enzyme (ECE) Inhibitors WS 75624A and WS 75624B via a cross-metathesis approach &bull Ent-kaurene derivatives as anti-inflammatory agents &bull Desmosdumotin C analogs as potent antitumor agents acting via activation of spindle assembly checkpoint &bull Imidazolo[2,1-b]benzothiazole derivatives as potential p53 inhibitors
Uses
Trimethylsilyldiazomethane is used as one-carbon homologation reagent; stable, safe substitute for diazomethane;participating in the synthesis reactions of insertion reactions;ketenylation reactions;preparation of homoallylic sulfides;pericyclic reactions;[C-N-N] 1,3-dipole for the preparation of azoles.
Uses
(Trimethylsilyl)diazomethane is used as an analyte in the determination of some phenolic organohalogens in human serum by GC-MS.
Preparation
Trimethylsilyldiazomethane is prepared by the diazo-transfer reaction of trimethylsilylmethylmagnesium chloride with diphenyl phosphorazidate (DPPA) (eq 1).
General Description
(Trimethylsilyl)diazomethane is considered as a non-explosive substitute to diazomethane for the homologation of carbonyl derivatives, mainly ketones, via reactions such as Tiffeneau-Demjanov rearrangement.
(Trimethylsilyl)diazomethane Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai Siyan Biological Technology Co., Ltd. | 021-50908862，442785678，326799392 18721037013 | siyansales@126.com | China | 9612 | 58 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Shanghai qiyan medicine technology co., ltd | 15021941186 | 3572772243@qq.com | China | 163 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Beijing Donghualituo Techonlogy Development Co.,Ltd. | 010-88425576 | sales@dhltchem.com | China | 793 | 59 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Beijing dtftchem Technology Co., Ltd. | 010-60275820 13031183356 | elainezt@sina.com | China | 1386 | 62 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
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- May 18,2026
View Latest Price from (Trimethylsilyl)diazomethane manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-02 | (Trimethylsilyl)diazomethane solution 2.0 M in diethyl ether
18107-18-1
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | (TRIMETHYLSILYL)DIAZOMETHANE
18107-18-1
|
$1.00 | 1G | 99% | 100kg | Career Henan Chemical Co |
-
- (Trimethylsilyl)diazomethane solution 2.0 M in diethyl ether
18107-18-1
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- (TRIMETHYLSILYL)DIAZOMETHANE
18107-18-1
- $1.00
- 99%
- Career Henan Chemical Co
