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ChemicalBook >> CAS DataBase List >>2-[(E)-(1-Benzyl-4-piperidinyl)methylidene]-5,6-dimethoxy-1-indanone

2-[(E)-(1-Benzyl-4-piperidinyl)methylidene]-5,6-dimethoxy-1-indanone

2-[(E)-(1-Benzyl-4-piperidinyl)methylidene]-5,6-dimethoxy-1-indanone Structure
2-[(E)-(1-Benzyl-4-piperidinyl)methylidene]-5,6-dimethoxy-1-indanone structure
CAS No.
145546-80-1
Chemical Name:
2-[(E)-(1-Benzyl-4-piperidinyl)methylidene]-5,6-dimethoxy-1-indanone
Synonyms
Donepezil-USP-A;Donepezil-013-E;(2E)-Dehydrodonepezil;Donepezil impurity 01;(E)-Dehydro Donepezil;Donepezil EP Impurity F;Donepezil Impurity A(USP);Donepezil related coMpound A;Donepezil Related Compound I;Donepezil Related Compound 1
CBNumber:
CB11229382
Molecular Formula:
C24H27NO3
Molecular Weight:
377.48
MDL Number:
MOL File:
145546-80-1.mol
MSDS File:
SDS
Last updated:2026-09-12 18:48:36
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2-[(E)-(1-Benzyl-4-piperidinyl)methylidene]-5,6-dimethoxy-1-indanone Properties

Melting point 175-177 °C
Boiling point 542.8±50.0 °C(Predicted)
Density 1.209±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Sparingly), Methanol (Slightly)
form Solid
pka 8.17±0.10(Predicted)
color Pale Yellow to Light Yellow
Major Application pharmaceutical (small molecule)
InChI 1S/C24H27NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,12,14-15,17H,8-11,13,16H2,1-2H3/b20-12+
InChIKey LPMOTUSFDTTWJL-UDWIEESQSA-N
SMILES N2(CCC(CC2)\C=C3/Cc4c(cc(c(c4)OC)OC)C/3=O)Cc1ccccc1
CAS DataBase Reference 145546-80-1
FDA UNII 1D3K90DIY3
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H300
Precautionary statements  P264-P270-P301+P310-P405-P501
WGK Germany  WGK 1
HS Code  2933399090
Storage Class 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials
Hazard Classifications Acute Tox. 2 Oral

2-[(E)-(1-Benzyl-4-piperidinyl)methylidene]-5,6-dimethoxy-1-indanone price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1224992 Donepezil related compound A United States Pharmacopeia (USP) Reference Standard 145546-80-1 25mg $1390 2026-04-30 Buy
aablocks AA001D3F (2E)-2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methylene]-1H-inden-1-one 97% 145546-80-1 250mg $35 2026-05-28 Buy
aablocks AA001D3F (2E)-2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methylene]-1H-inden-1-one 97% 145546-80-1 1g $76 2026-05-28 Buy
ACHEMBLOCK AD240282 (2E)-2-[(1-benzylpiperidin-4-yl)methylidene]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one 98% 145546-80-1 1G $160 2026-05-27 Buy
ACHEMBLOCK AD240282 (2E)-2-[(1-benzylpiperidin-4-yl)methylidene]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one 98% 145546-80-1 5G $410 2026-05-27 Buy
Product number Packaging Price Buy
1224992 25mg $1390 Buy
AA001D3F 250mg $35 Buy
AA001D3F 1g $76 Buy
AD240282 1G $160 Buy
AD240282 5G $410 Buy

2-[(E)-(1-Benzyl-4-piperidinyl)methylidene]-5,6-dimethoxy-1-indanone Chemical Properties, Uses, Production

Uses

(2E)-Dehydrodonepezil (Donepezil USP Related Compound A) is a derivative of Donepezil (D531750), a nootropic. An inhibitor of acetylcholinesterase.

2-[(E)-(1-Benzyl-4-piperidinyl)methylidene]-5,6-dimethoxy-1-indanone Preparation Products And Raw materials

Raw materials

Preparation Products

2-[(E)-(1-Benzyl-4-piperidinyl)methylidene]-5,6-dimethoxy-1-indanone Suppliers

Global Suppliers ( 102)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123 sj_scrc@sinopharm.com China 9791 79
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4773 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Quality Control Solutions Ltd. 0755-66853366 13670046396 orders@qcsrm.com China 18188 56
Shanghai Kewel Chemical Co., Ltd. 021-64609169 18901607656 greensnown@163.com China 9883 50
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66028182 17714375163 yftan@aikonchem.com China 16674 50
Nanjing XiZe Biotechnology CO., Ltd. 025-66023220 15250997978 1511893459@qq.com China 4777 55
Zibo RuiYuan Chemical Co., Ltd. 0533-4680953 15169375653 474852096@qq.com China 19 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Adamas Reagent, Ltd. 59
Sinopharm Chemical Reagent Co,Ltd. 79
Guangzhou Isun Pharmaceutical Co., Ltd 55
Bide Pharmatech Ltd. 60
Quality Control Solutions Ltd. 56
Shanghai Kewel Chemical Co., Ltd. 50
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 50
Nanjing XiZe Biotechnology CO., Ltd. 55
Zibo RuiYuan Chemical Co., Ltd. 58

View Latest Price from 2-[(E)-(1-Benzyl-4-piperidinyl)methylidene]-5,6-dimethoxy-1-indanone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Donepezil Impurity A pictures 2025-12-19 Donepezil Impurity A
145546-80-1
 10mg 90%+ 10g Guangzhou PI PI BIOTECH INC
Donepezil Impurity A(USP) pictures 2025-12-19 Donepezil Impurity A(USP)
145546-80-1
 10mg 90%+ 10g Guangzhou PI PI BIOTECH INC
Donepezil Impurity A(USP) pictures 2025-12-19 Donepezil Impurity A(USP)
145546-80-1
 10mg 90%+ 10g Guangzhou PI PI BIOTECH INC

145546-80-1 (2-[(E)-(1-Benzyl-4-piperidinyl)methylidene]-5,6-dimethoxy-1-indanone) Related Search:

2-[(1-Benzylpiperidin-4-yl)hydroxyMethyl]-5,6-diMethoxyindan-1-one Donepezil Impurity 17 HCl 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine DONEPEZIL IMP Donepezil Impurity
1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-yl)methylpyridinium Bromide Donepezil Impurity 7 Donepezil Hydrochloride Donepezil XWAIAVWHZJNZQQ-RPXFAUAJSA-N
5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one 5,6-Dimethoxy-1-indanone Donepezil Impurity 8 Donepezil Impurity 5-O-Desmethyl Donepezil
5,6-Dimethoxy-2-pyridin-4-ylmethyl-indan-1-one 4-Pyridinecarboxaldehyde N-oxide Rac (cis/trans) donepezil N-oxide

1of4

Donepezil Related Compound A (25 mg) ((E)-2-[(1-benzylpiperidin-4-yl)methylene]-5,6-dimethoxyindan-1-one) Donepezil related coMpound A (2E)-Dehydrodonepezil Donepezil Related Compound A(USP) Donepezil-013-E (2E)-Dehydrodonepezil\n\n(Donepezil Impurity) 2-[(1-benzylpiperidin-4-yl)methylidene]-5,6-dimethoxy-3H-inden-1-one Donepezil EP Impurity F Donepezil impurity 1/Donepezil Related Compound A/Donepezil Dehydro Impurity/(2E)-Dehydro Donepezil/ (E)-2-[(1-Benzylpiperidin-4-yl)methylene]-5,6-dimethoxyindan-1-one Donepezil-USP-A Donepezil Impurity A(USP) Donepezil Related Compound I Donepezil USP Related Compound A 1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methylene]-, (2E)- 2-[(E)-(1-BENZYL-4-PIPERIDINYL)METHYLIDENE]-5,6-DIMET... Goserelin Acetate (COLD SHIPMENT REQUIRED) (1297205) Donepezil Related Compound A ((E)-2-[(1-benzylpiperidin-4-yl)methylene]-5,6-dimethoxyindan-1-one) (1224992) (2E)-2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methylene]-1H-inden-1-one Donepezil impurity 01 Donepezil Related Compound 1 (E)-Dehydro Donepezil (E)-2-[(1-Benzylpiperidin-4-yl)methylene]-5,6-dimethoxyindan- 1-one Donepezil EP Impurity F (Donepezil USP Related Compound A) Donepezil Impurity 9 (Donepezil EP Impurity F) 2-[(1-Benzyl-4-Piperidinyl)Methylene]-5,6-Dimethoxy-1-Indanone (E)-2-[(1-Benzylpiperidin-4-yl)methylene]-5,6-dimethoxyindan-1-one(Donepezil Related Compound A) (E)-2-((1-Benzylpiperidin-4-yl)methylene)-5 Donepezil EP Impurity F/ Donepezil USP Related Compound A / (E)-Dehydro Donepezil 145546-80-1