Z-VAL-DL-ASP-FLUOROMETHYLKETONE
- CAS No.
- 582316-00-5
- Chemical Name:
- Z-VAL-DL-ASP-FLUOROMETHYLKETONE
- Synonyms
- Z-VD-FMK;Z-Val-DL-Asp-FMK;Z-Val-Asp-Fluoromethyl Ketone;Z-VAL-DL-ASP-FLUOROMETHYLKETONE;Z-VAL-ASP-FLUOROMETHYL KETONE;Z-VD-FMK;3-({N-[(Benzyloxy)Carbonyl]-L-Valyl}Amino)-5-Fluoro-4-Oxopentanoic Acid;3-((S)-2-(((Benzyloxy)carbonyl)aMino)-3-MethylbutanaMido)-5-fluoro-4-oxopentanoic acid;Pentanoic acid,5-fluoro-3-[[(2S)-3-methyl-1-oxo-2-[[(phenylmethoxy)carbonyl]amino]butyl]amino]-4-oxo-
- CBNumber:
- CB1128033
- Molecular Formula:
- C18H23FN2O6
- Molecular Weight:
- 382.38
- MDL Number:
- MFCD08457673
- MOL File:
- 582316-00-5.mol
- MSDS File:
- SDS
Product description | Number | Pack Size | Price |
MX1013 | 27904 | 5mg | $68 |
MX1013 | 27904 | 10mg | $121 |
MX1013 | 27904 | 25mg | $268 |
Z-Val-Asp-FluoromethylKetone 96% | BP-22470 | 100mg | $540 |
Z-VAL-DL-ASP-FLUOROMETHYLKETONE 95.00% | API0004663 | 1MG | $554 |
Z-VAL-DL-ASP-FLUOROMETHYLKETONE price More Price(13)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 27904 | MX1013 | 582316-00-5 | 5mg | $68 | 2024-03-01 | Buy |
Cayman Chemical | 27904 | MX1013 | 582316-00-5 | 10mg | $121 | 2024-03-01 | Buy |
Cayman Chemical | 27904 | MX1013 | 582316-00-5 | 25mg | $268 | 2024-03-01 | Buy |
BroadPharm | BP-22470 | Z-Val-Asp-FluoromethylKetone 96% | 582316-00-5 | 100mg | $540 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0004663 | Z-VAL-DL-ASP-FLUOROMETHYLKETONE 95.00% | 582316-00-5 | 1MG | $554 | 2021-12-16 | Buy |
Z-VAL-DL-ASP-FLUOROMETHYLKETONE Chemical Properties,Uses,Production
Uses
MX1013 is a potent, irreversible dipeptide caspase inhibitor vith?antiapoptotic activity. MX1013 inhibits recombinant human caspase 3 with an IC50?of 30 nM[1].
in vivo
MX1013 is an effective antiapoptotic agent?in vivo. MX1013 not only inhibits local tissue apoptosis, but also can protect animals against its lethal effects[1].
Animal Model: | Female ND4 Swiss Webster mice (16.5-21 g)[1] |
Dosage: | 0, 0.25, 1, 10 mg/kg (formulated in an aqueous vehicle containing 50 mm?Tris-HCl, pH 8.0) |
Administration: | Injected i.v. |
Result: | The lowest dose of 0.25 mg/kg protected 66% of the mice from the lethal effects of anti-Fas antibody at the 3 h time point, and 1 and 10 mg/kg?dose protected 100% of the mice at the 3 h time point. |
IC 50
Caspase
References
[1] Wu Yang,?et al. MX1013, a dipeptide caspase inhibitor with potent in vivo antiapoptotic activity. Br J Pharmacol.?2003 Sep;140(2):402-12. DOI:10.1038/sj.bjp.0705450
Z-VAL-DL-ASP-FLUOROMETHYLKETONE Preparation Products And Raw materials
Raw materials
Preparation Products
Z-VAL-DL-ASP-FLUOROMETHYLKETONE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32434 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39032 | 58 |
Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9793 | 50 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |