3-Pyridinecarbonitrile,5-hydroxy-(9CI)
- CAS No.
- 152803-24-2
- Chemical Name:
- 3-Pyridinecarbonitrile,5-hydroxy-(9CI)
- Synonyms
- 5-Hydroxynicotinonitrile;3-Cyano-5-hydroxypyridine;5-isocyano-pyridin-3-ol;5-Cyano-3-Hydroxypyridine;3-Hydroxy-5-Cyanopyridine;3-Cyano-5-hydroxypyridine,97%;5-Hydroxynicotinonitrile 97%;3-Pyridinecarbonitrile,5-hydroxy;3-Pyridinecarbonitrile,5-hydroxy-(9CI);3-Pyridinecarbonitrile,5-hydroxy-(9cl)
- CBNumber:
- CB11287472
- Molecular Formula:
- C6H4N2O
- Molecular Weight:
- 120.11
- MDL Number:
- MFCD11044307
- MOL File:
- 152803-24-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Hydroxynicotinonitrile 98% | OR301211 | 1g | $21 |
| 5-Hydroxynicotinonitrile 98% | OR301211 | 5g | $36 |
| 3-Cyano-5-hydroxypyridine 97% | AS31176 | 1g | $28 |
| 5-Hydroxynicotinonitrile 98% | OR301211 | 25g | $160 |
| 3-Cyano-5-hydroxypyridine 97% | AS31176 | 5g | $74 |
| More product size | |||
| Melting point | 213-217℃ |
|---|---|
| Boiling point | 394.7±27.0 °C(Predicted) |
| Density | 1.33±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | 7.96±0.10(Predicted) |
| Appearance | Off-white to light yellow Solid |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C6H4N2O/c7-2-5-1-6(9)4-8-3-5/h1,3-4,9H |
| InChIKey | KAXIYYPIORYZLB-UHFFFAOYSA-N |
| SMILES | C1=NC=C(O)C=C1C#N |
| CAS DataBase Reference | 152803-24-2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H315-H319-H331-H335 | |||||||||
| Precautionary statements | P261-P280-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| RIDADR | 3439 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
3-Pyridinecarbonitrile,5-hydroxy-(9CI) price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR301211 | 5-Hydroxynicotinonitrile 98% | 152803-24-2 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR301211 | 5-Hydroxynicotinonitrile 98% | 152803-24-2 | 5g | $36 | 2026-06-04 | Buy |
| Activate Scientific | AS31176 | 3-Cyano-5-hydroxypyridine 97% | 152803-24-2 | 1g | $28 | 2026-06-04 | Buy |
| Apolloscientific | OR301211 | 5-Hydroxynicotinonitrile 98% | 152803-24-2 | 25g | $160 | 2026-06-04 | Buy |
| Activate Scientific | AS31176 | 3-Cyano-5-hydroxypyridine 97% | 152803-24-2 | 5g | $74 | 2026-06-04 | Buy |
3-Pyridinecarbonitrile,5-hydroxy-(9CI) Chemical Properties,Uses,Production
Uses
3-Cyano-5-hydroxypyridine is active pharmaceutical ingredients.
Synthesis
298204-74-7
152803-24-2
General procedure for the synthesis of 3-cyano-5-hydroxypyridine from 5-methoxynicotinonitrile: 1 g of 5-methoxynicotinonitrile (7.46 mmol) was mixed with 8.62 g of pyridine hydrochloride, and the reaction was heated at 200 °C for 2 hours. After completion of the reaction, the crude product was diluted with water and extracted several times with ether. The aqueous phase was alkalized by addition of sodium bicarbonate and extracted again with ether. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 850 mg of 5-hydroxynicotinonitrile as a beige solid in 95% yield. The product was analyzed by LC-MS: m/z 120.94 (M+H+). 1H NMR (400 MHz, DMSO-d6): δ 10.79 (s, 1H, OH), 8.46 (s, 1H, Harom.), 8.42 (s, 1H, Harom.), 7.60 (s, 1H, Harom.).
References
[1] Patent: WO2012/101239, 2012, A1. Location in patent: Page/Page column 74
[2] Patent: US2013/85144, 2013, A1. Location in patent: Paragraph 0394; 0395; 0396
[3] Patent: EP2689778, 2014, A1. Location in patent: Paragraph 0238
[4] Patent: WO2014/16433, 2014, A1. Location in patent: Page/Page column 73
[5] Patent: WO2014/16434, 2014, A1. Location in patent: Page/Page column 72
3-Pyridinecarbonitrile,5-hydroxy-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29640 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5746 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
View Lastest Price from 3-Pyridinecarbonitrile,5-hydroxy-(9CI) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-25 | 3-Pyridinecarbonitrile,5-hydroxy-(9CI)
152803-24-2
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2022-01-06 | 5-HYDROXYNICOTINONITRILE
152803-24-2
|
$60.00 | 1000KG | 99% | 20 tons | Honest Joy Holdings Limited | |
 |
2020-01-08 | 3-Pyridinecarbonitrile,5-hydroxy-(9CI)
152803-24-2
|
$2.00 | 1g | 98%MIN | Career Henan Chemical Co |
-
- 3-Pyridinecarbonitrile,5-hydroxy-(9CI)
152803-24-2
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 5-HYDROXYNICOTINONITRILE
152803-24-2
- $60.00
- 99%
- Honest Joy Holdings Limited
-
- 3-Pyridinecarbonitrile,5-hydroxy-(9CI)
152803-24-2
- $2.00
- 98%MIN
- Career Henan Chemical Co
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