4-Amino-3-fluoropyridine
- CAS No.
- 2247-88-3
- Chemical Name:
- 4-Amino-3-fluoropyridine
- Synonyms
- 3-FLUOROPYRIDIN-4-AMINE;3-FLUORO-4-AMINOPYRIDINE;4-Amin;fluoropyridin-4-amine;4-AMINO-3-FLUOROPYRINE;3-Fluoro-4-pyridinamine;4-AMINO-3-FLUOROPYRIDINE;4-Pyridinamine, 3-fluoro-;3-fluoropyridin-4-amine 97%;4-Amino-3-fluoropyridine >
- CBNumber:
- CB3396951
- Molecular Formula:
- C5H5FN2
- Molecular Weight:
- 112.11
- MDL Number:
- MFCD00234072
- MOL File:
- 2247-88-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 71-79 °C |
|---|---|
| Boiling point | 217.1±20.0 °C(Predicted) |
| Density | 1.257±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 7.19±0.12(Predicted) |
| color | White to Light yellow to Light orange |
| InChI | InChI=1S/C5H5FN2/c6-4-3-8-2-1-5(4)7/h1-3H,(H2,7,8) |
| InChIKey | UFIKBUVVVGSMGW-UHFFFAOYSA-N |
| SMILES | C1=NC=CC(N)=C1F |
| CAS DataBase Reference | 2247-88-3(CAS DataBase Reference) |
| FDA UNII | Y744OES4EP |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22-36 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | nwg | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
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| NFPA 704 |
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4-Amino-3-fluoropyridine price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 704490 | 4-Amino-3-fluoropyridine 97% | 2247-88-3 | 1g | $114 | 2026-04-30 | Buy |
| TCI Chemical | A2383 | 4-Amino-3-fluoropyridine >98.0%(GC)(T) | 2247-88-3 | 1g | $84 | 2026-04-30 | Buy |
| TCI Chemical | A2383 | 4-Amino-3-fluoropyridine >98.0%(GC)(T) | 2247-88-3 | 5g | $332 | 2026-04-30 | Buy |
| Apolloscientific | PC1163 | 4-Amino-3-fluoropyridine 97% | 2247-88-3 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC1163 | 4-Amino-3-fluoropyridine 97% | 2247-88-3 | 5g | $75 | 2026-06-04 | Buy |
4-Amino-3-fluoropyridine Chemical Properties, Uses, Production
Preparation
In a 250 ml reaction flask, add 50 ml of water and 5.4 g of sodium hydroxide. Cool the reaction mixture to 0–5 °C. Add 4.7 g of liquid bromine dropwise to the reaction mixture. After the addition is complete, stir at 0–5 °C for 2 hours. Add 5.0 g of 3-fluoro-4-pyridinecarboxamide to the reaction flask. Stir at 0–5 °C for 2 hours until the solid is completely dissolved. Heat the reaction mixture to 85 °C. Maintain the reaction at 85 °C for 6 hours. Cool the reaction mixture to room temperature. Add 50 ml of ethyl acetate to the reaction flask to extract the product. Separate the organic layer and extract the aqueous layer twice with ethyl acetate. Combine the organic layers. 3.0 g of the pale brownish-red solid powder product, 4-amino-3-fluoropyridine, was obtained by drying and evaporating the solvent, with a yield of 81% and a purity of 96%.
Chemical Properties
Yellow to light yellow crystals
Uses
4-Amino-3-fluoropyridine is an important intermediate in the synthesis of many new drugs, and it is an intermediate in the synthesis of transforming growth factor-β inhibitors and thrombin inhibitors.
4-Amino-3-fluoropyridine Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChengDu TongChuangYuan Pharmaceutical Co.Ltd | 28-83379370 13880556291 | tcy@tcypharm.com | China | 509 | 57 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Latest Price from 4-Amino-3-fluoropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 4-Amino-3-fluoropyridine
2247-88-3
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-06-30 | 4-Amino-3-fluoropyridine
2247-88-3
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-12-31 | 4-Amino-3-fluoropyridine
2247-88-3
|
$1.00 | 1KG | 99% | 1000KGS | Career Henan Chemical Co |
-
- 4-Amino-3-fluoropyridine
2247-88-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4-Amino-3-fluoropyridine
2247-88-3
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-Amino-3-fluoropyridine
2247-88-3
- $1.00
- 99%
- Career Henan Chemical Co
