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2-Amino-4-phenyl-thiophene-3-carboxylic acid ethyl ester

2-Amino-4-phenyl-thiophene-3-carboxylic acid ethyl ester Structure
2-Amino-4-phenyl-thiophene-3-carboxylic acid ethyl ester structure
CAS No.
4815-36-5
Chemical Name:
2-Amino-4-phenyl-thiophene-3-carboxylic acid ethyl ester
Synonyms
ETHYL 2-AMINO-4-PHENYLTHIOPHENE-3-CARBOXYLATE;AURORA 20210;AKOS B000514;AKOS MSC-0434;AKOS BBS-00002683;BUTTPARK 30\06-09;ART-CHEM-BB B000514;IFLAB-BB F1018-1557;CHEMBRDG-BB 3000514;TIMTEC-BB SBB006987
CBNumber:
CB1129601
Molecular Formula:
C13H13NO2S
Molecular Weight:
247.31
MDL Number:
MFCD00126391
MOL File:
4815-36-5.mol
MSDS File:
SDS
Last updated:2026-09-12 18:48:36
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2-Amino-4-phenyl-thiophene-3-carboxylic acid ethyl ester Properties

Melting point 92-97 °C
Boiling point 391.0±42.0 °C(Predicted)
Density 1.231
storage temp. 2-8°C(protect from light)
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml; Ethanol: 20 mg/ml
form A crystalline solid
pka -0.14±0.10(Predicted)
InChI 1S/C13H13NO2S/c1-2-16-13(15)11-10(8-17-12(11)14)9-6-4-3-5-7-9/h3-8H,2,14H2,1H3
InChIKey WYTHTMKMOSPACP-UHFFFAOYSA-N
SMILES CCOC(=O)c1c(N)scc1-c2ccccc2
CAS DataBase Reference 4815-36-5(CAS DataBase Reference)
EWG's Food Scores 1
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37/39
WGK Germany  3
HazardClass  IRRITANT
HS Code  29349990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

2-Amino-4-phenyl-thiophene-3-carboxylic acid ethyl ester price More Price(57)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 717401 Ethyl 2-amino-4-phenylthiophene-3-carboxylate 97% 4815-36-5 1g $61.8 2023-01-07 Buy
Cayman Chemical 13387 ethyl-2-amino-4-phenyl Thiophene-3-Carboxylate ≥98% 4815-36-5 100mg $18 2026-04-30 Buy
Cayman Chemical 13387 ethyl-2-amino-4-phenyl Thiophene-3-Carboxylate ≥98% 4815-36-5 250mg $36 2026-04-30 Buy
Cayman Chemical 13387 ethyl-2-amino-4-phenyl Thiophene-3-Carboxylate ≥98% 4815-36-5 500mg $62 2026-04-30 Buy
Cayman Chemical 13387 ethyl-2-amino-4-phenyl Thiophene-3-Carboxylate ≥98% 4815-36-5 1g $91 2026-04-30 Buy
Product number Packaging Price Buy
717401 1g $61.8 Buy
13387 100mg $18 Buy
13387 250mg $36 Buy
13387 500mg $62 Buy
13387 1g $91 Buy

2-Amino-4-phenyl-thiophene-3-carboxylic acid ethyl ester Chemical Properties, Uses, Production

Chemical Properties

Yellow solid

Uses

2-Amino-4-phenyl-thiophene-3-carboxylic acid ethyl ester is a synthetic intermediate useful for pharmaceutical synthesis.

Uses

Ethyl 2-Amino-4-phenylthiophene-3-carboxylate is used in the design and synthesis of thieno[2,3-d]pyrimidine analogs which exhibits antiproliferative activity against human cancer cells such as liver, pancreatic and colorectal cancer.

Synthesis

2-Butenoic acid, 2-cyano-3-phenyl-, ethyl ester, (2Z)-

17277-47-3

2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER

4815-36-5

Ethyl 2-cyano-3-phenylbut-2-enoate (513.25 g, 2.3 mol) was slowly added to a vigorously stirred ethanol (500 mL) suspension of sulfur powder (76 g, 2.3 mol) at room temperature. Subsequently, diethylamine (200 mL) was added in batches over a period of 20 min, and the temperature was raised to 62 °C during the reaction. Upon completion of the reaction, the mixture was cooled to 36 °C, then heated to 50 °C and stirred continuously for 1 h at this temperature. After stopping stirring, unreacted sulfur was removed by decantation and the hot solution was cooled to room temperature. The resulting orange solid product, ethyl 2-amino-4-phenylthiophene-3-carboxylate (195 g) was collected by filtration and washed with a small amount of cold ethanol and finally dried under vacuum. The resulting product was used for subsequent experiments without further purification.

References

[1] Synthetic Communications, 2007, vol. 37, # 23, p. 4273 - 4279
[2] Patent: WO2012/131379, 2012, A1. Location in patent: Page/Page column 19
[3] Patent: US2014/206703, 2014, A1. Location in patent: Paragraph 0033; 0084; 0085

2-Amino-4-phenyl-thiophene-3-carboxylic acid ethyl ester Preparation Products And Raw materials

Raw materials

Sulfur Ethanol Diethylamine Acetophenone Benzene
Acetic acid Ammonium acetate Ethyl cyanoacetate (E)-2-Cyano-3-phenyl-but-2-enoic acid ethyl ester Morpholine

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Preparation Products

4-Chloro-5-phenylthieno[2,3-d]pyrimidine 2-(2-Cyano-acetylamino)-4-phenyl-thiophene-3-carboxylic acid ethyl ester ethyl 2-acetamido-4-phenylthiophene-3-carboxylate Thieno[2,3-d]pyrimidin-4(1H)-one, 3-cyclohexyl-2,3-dihydro-5-phenyl-2-thioxo- 4-phenyl-2-Thiophenamine
2-Benzyl-4-chloro-5-phenylthieno[2,3-d]pyriMidine

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2-Amino-4-phenyl-thiophene-3-carboxylic acid ethyl ester Suppliers

Global Suppliers ( 156)
Supplier Tel Email Country ProdList Advantage
Heze Bona Medical Technology Co., LTD 15865805009 15865805009@139.com China 2995 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Nanjing Habo Medical Technology Co., Ltd. 13376080562 13376090521 sales@habotech.com China 725 60
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16305 64
China Langchem Inc. 0086-21-58956006 China 7798 57
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 85114309 18982182443 yangli@happysyn.com China 2284 55
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9510 58
Shanghai Topbiochem Technology Co., Ltd +86-21-60341587 sales@topbiochem.com China 6166 58
Supplier Advantage
Heze Bona Medical Technology Co., LTD 58
J & K SCIENTIFIC LTD. 76
Wuhan Chemwish Technology Co., Ltd 56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Nanjing Habo Medical Technology Co., Ltd. 60
Nanjing Chemlin Chemical Co., Ltd 64
China Langchem Inc. 57
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 55
Shanghai Topbiochem Technology Co., Ltd 58
Shanghai Topbiochem Technology Co., Ltd 58

View Latest Price from 2-Amino-4-phenyl-thiophene-3-carboxylic acid ethyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER pictures 2026-08-20 2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
4815-36-5
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited
2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER pictures 2021-08-12 2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
4815-36-5
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

4815-36-5 (2-Amino-4-phenyl-thiophene-3-carboxylic acid ethyl ester) Related Search:

2-Amino-4-phenyl-thiophene-3-carboxylic acid ethyl ester Ethyl thiophene-3-carboxylate Ethyl 2-amino-4-(4-bromophenyl)-3-thiophenecarboxylate Ethyl 2-amino-5-phenylthiophene-3-carboxylate Ethyl 2-amino-4-(4-fluorophenyl)thiophene-3-carboxylate
2-(2-Chloro-acetylamino)-4-p-tolyl-thiophene-3-carboxylic acid ethyl ester 2-(2-Chloro-acetylamino)-4-phenyl-thiophene-3-carboxylic acid ethyl ester 2-Amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylic acid ethyl ester Ethyl 2-(acetylamino)-4-(4-fluorophenyl)thiophene-3-carboxylate Ethyl 2-amino-5-ethyl-4-phenylthiophene-3-carboxylate
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IFLAB-BB F1018-1557 ETHYL 2-AMINO-4-PHENYL-3-THIOPHENECARBOXYLATE CHEMBRDG-BB 3000514 AURORA 20210 BUTTPARK 30\06-09 ART-CHEM-BB B000514 2-AMINO-4-PHENYL-3-THIOPHENECARBOXYLIC ACID, ETHYL ESTER AKOS MSC-0434 AKOS BBS-00002683 AKOS B000514 3-THIOPHENECARBOXYLIC ACID, 2-AMINO-4-PHENYL-, ETHYL ESTER TIMTEC-BB SBB006987 2-amino-4-phenyl-thiophene-3-carboxylicaciethylester 2-AMino-4-phenylthiophene-3-carboxylate amino-2ethoxycarbonyl-3phenyl-4thiophene 2-Amino-4-phenyl-thiophene-3-carboxylic acid ethyl ester ,98% Amino-2 ethoxycarbonyl-3 phenyl-4 thiophene [French] Thiophene-3-carboxylic acid, 2-amino-4-phenyl-, ethyl ester ethyl 2-amino-4-phenylthiophene-3-carboxylate(SALTDATA: FREE) 2-AMINO-4-PHENYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER ISO 9001：2015 REACH 2-Amino-3-(ethoxycarbonyl)-4-phenylthiophene 2-Amino-4-phenylthiophen-3-carboxylic acid ethyl ester ethyl 2-amino-4-phenyl-thiophene-3-carboxy Ethyl 2-amino-4-phenylthiophen-3-carboxylate ETHYL 2-AMINO-4-PHENYLTHIOPHENE-3-CARBOXYLATE 2-Amino-4-phenyl-thiophene-3-carboxylic acid ethyl ester 4815-36-5