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ChemicalBook >> CAS DataBase List >>2-Amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylic acid ethyl ester

2-Amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylic acid ethyl ester

2-Amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylic acid ethyl ester Structure
2-Amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylic acid ethyl ester structure
CAS No.
15854-12-3
Chemical Name:
2-Amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylic acid ethyl ester
Synonyms
aPKC-IN-1;Ethyl 2-amino-4-(3,4-dimethoxyphenyl)-3-thiophenecarboxylate;2-amino-4-(3,4-dimethoxyphenyl)-3-thiophenecarboxylic acid ethyl ester;3-Thiophenecarboxylic acid, 2-amino-4-(3,4-dimethoxyphenyl)-, ethyl ester
CBNumber:
CB01499874
Molecular Formula:
C15H17NO4S
Molecular Weight:
307.36
MDL Number:
MFCD00499458
MOL File:
15854-12-3.mol
MSDS File:
SDS
Last updated:2026-09-12 18:44:34
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2-Amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylic acid ethyl ester Properties

Boiling point 437.3±45.0 °C(Predicted)
Density 1.234±0.06 g/cm3(Predicted)
pka -0.29±0.10(Predicted)
form solid
InChI 1S/C15H17NO4S/c1-4-20-15(17)13-10(8-21-14(13)16)9-5-6-11(18-2)12(7-9)19-3/h5-8H,4,16H2,1-3H3
InChIKey OZWGHIQPWZHYPG-UHFFFAOYSA-N
SMILES [s]1c(c(c(c1)c2cc(c(cc2)OC)OC)C(=O)OCC)N
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H318
Precautionary statements  P280-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-41
Safety Statements  26-39
WGK Germany  3
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1

2-Amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylic acid ethyl ester price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich OTV000270 Ethyl 2-amino-4-(3,4-dimethoxyphenyl)-3-thiophenecarboxylate Aldrich 15854-12-3 1g $230 2026-04-30 Buy
Matrix Scientific 028952 Ethyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 15854-12-3 500.00mg $126 2026-05-18 Buy
aablocks AA001Q6Y 2-Amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylic acid ethyl ester 90% 15854-12-3 5mg $123 2026-05-28 Buy
aablocks AA001Q6Y 2-Amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylic acid ethyl ester 90 15854-12-3 500mg $649 2026-05-28 Buy
aablocks AA001Q6Y 2-Amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylic acid ethyl ester 90 15854-12-3 1g $729 2026-05-28 Buy
Product number Packaging Price Buy
OTV000270 1g $230 Buy
028952 500.00mg $126 Buy
AA001Q6Y 5mg $123 Buy
AA001Q6Y 500mg $649 Buy
AA001Q6Y 1g $729 Buy

2-Amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylic acid ethyl ester Chemical Properties, Uses, Production

Uses

aPKC-IN-1 (compound 1) is an atypical protein kinase C (aPKCζ) inhibitor. aPKC-IN-1 can be used for the study of a host of diseases involving increased vascular permeability and inflammation[1].

References

[1] Paul M Titchenellm, et al. Synthesis and structure-activity relationships of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors. Bioorg Med Chem Lett. 2013 May 15;23(10):3034-8. DOI:10.1016/j.bmcl.2013.03.019

2-Amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylic acid ethyl ester synthesis

105-56-6
1131-62-0
15854-12-3
Synthesis of 2-Amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylic acid ethyl ester from Ethyl cyanoacetate and 3,4-Dimethoxyacetophenone

2-Amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylic acid ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

3-Thiophenecarboxylic acid, 2-amino-4-(3,4-dimethoxyphenyl)-

2-Amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylic acid ethyl ester Suppliers

Global Suppliers ( 20)
Supplier Tel Email Country ProdList Advantage
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66028182 17714375163 yftan@aikonchem.com China 16674 50
Shanghai Brain Biotechnology Co., Ltd. 13564638271 shhjiang1977@163.com China 2983 55
Changzhou Hopschain Chemical Co.,Ltd. 85528066 13775048983 sales@hopschem.com China 31548 55
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44871 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Nanjing Shizhou Biology Technology Co.,Ltd -- purchase@synzest.com China 6856 58
Shandong Libixi Biopharmaceutical Technology Co., Ltd. 15318973357; 15318973357 1460285141@qq.com China 9642 58
Changzhou Exploring Chemical Co., Ltd 15295164949 3035159494@qq.com China 2207 58
Changzhou Tsour Chemical Co.,Ltd +8615295164949 xuf@tsourchem.com China 2349 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 50
Shanghai Brain Biotechnology Co., Ltd. 55
Changzhou Hopschain Chemical Co.,Ltd. 55
Energy Chemical 58
TargetMol Chemicals Inc. 58
Nanjing Shizhou Biology Technology Co.,Ltd 58
Shandong Libixi Biopharmaceutical Technology Co., Ltd. 58
Changzhou Exploring Chemical Co., Ltd 58
Changzhou Tsour Chemical Co.,Ltd 58
TargetMol Chemicals Inc. 58

View Latest Price from 2-Amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylic acid ethyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
aPKC-I pictures 2026-05-11 aPKC-I
15854-12-3
 $1520.00-2500.00 10g TargetMol Chemicals Inc.
  • aPKC-I pictures
  • aPKC-I
    15854-12-3
  • $1520.00-2500.00
  • TargetMol Chemicals Inc.

15854-12-3 (2-Amino-4-(3,4-dimethoxy-phenyl)-thiophene-3-carboxylic acid ethyl ester) Related Search:

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Ethyl 2-amino-4-(3,4-dimethoxyphenyl)-3-thiophenecarboxylate 2-amino-4-(3,4-dimethoxyphenyl)-3-thiophenecarboxylic acid ethyl ester 3-Thiophenecarboxylic acid, 2-amino-4-(3,4-dimethoxyphenyl)-, ethyl ester aPKC-IN-1 15854-12-3