cyclo(L-leucyl-L-tryptophyl)
- CAS No.
- 15136-34-2
- Chemical Name:
- cyclo(L-leucyl-L-tryptophyl)
- Synonyms
- c(Leu-Trp);Cyclo(Trp-Leu);cyclo-L-Trp-L-Leu;Cyclo(L-Leu-L-Trp);cyclo(L-leucyl-L-tryptophyl);(3S,6S)-3-(1H-indol-3-ylmethyl)-6-(2-methylpropyl)piperazine-2,5-dione;2,5-Piperazinedione, 3-(1H-indol-3-ylmethyl)-6-(2-methylpropyl)-, (3S,6S)-
- CBNumber:
- CB11307048
- Molecular Formula:
- C17H21N3O2
- Molecular Weight:
- 299.37
- MDL Number:
- MOL File:
- 15136-34-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Cyclo(L-Leu-L-Trp) ≥95% | 24942 | 5mg | $267 |
| Cyclo(L-Leu-L-Trp) ≥95% | 24942 | 25mg | $931 |
| Cyclo(-Leu-Trp) | FC108311 | 10mg | $229.7 |
| Cyclo(-Leu-Trp) | FC108311 | 25mg | $430.75 |
| Cyclo(-Leu-Trp) | FC108311 | 50mg | $670 |
cyclo(L-leucyl-L-tryptophyl) price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 24942 | Cyclo(L-Leu-L-Trp) ≥95% | 15136-34-2 | 5mg | $267 | 2026-04-30 | Buy |
| Cayman Chemical | 24942 | Cyclo(L-Leu-L-Trp) ≥95% | 15136-34-2 | 25mg | $931 | 2026-04-30 | Buy |
| Biosynth | FC108311 | Cyclo(-Leu-Trp) | 15136-34-2 | 10mg | $229.7 | 2026-06-04 | Buy |
| Biosynth | FC108311 | Cyclo(-Leu-Trp) | 15136-34-2 | 25mg | $430.75 | 2026-06-04 | Buy |
| Biosynth | FC108311 | Cyclo(-Leu-Trp) | 15136-34-2 | 50mg | $670 | 2026-06-04 | Buy |
cyclo(L-leucyl-L-tryptophyl) Chemical Properties,Uses,Production
Description
Cyclo(L-Leu-L-Trp) is a diketopiperazine metabolite originally isolated from Penicillium.1 It is active against various bacteria (MICs = 125-1000 μg/ml) and fungi (MICs = 8-64 μg/ml), and it inhibits the production rate of hydroxy radicals in an electron spin resonance (ESR) spectroscopy-based assay (IC50 = 1.8 μM).2,3 Cyclo(L-Leu-L-Trp) is a bitter tastant that can rapidly permeate rat taste cell membranes ex vivo when used at a concentration of 1 mM.4 It also acts as a melatonin receptor agonist in X. laevis melanophores, inhibiting cAMP accumulation when used at a concentration of 20 μM, an effect that is blocked by the melatonin receptor antagonist luzindole .5
Uses
Cyclo(L-leucyl-L-tryptophyl) (Cyclo(-Leu-Trp)) is a cyclic dipeptide that inhibits a various of bacteria and fungi. Cyclo(L-leucyl-L-tryptophyl) is a melatonin receptor agonist and is also used as a bitter ligand[1][2][3].
References
1. Solov'eva, T.F., Baskunov, B.P., Nefedova, M.Y., et al. Biosynthesis of leucyl-
2. Kumar, S.N., Mohandas, C., and Nambisan, B. Purification, structural elucidation and bioactivity of tryptophan containing diketopiperazines, from Comamonas testosteroni associated with a rhabditid entomopathogenic nematode against major human-
3. Furukawa, T., Akutagawa, T., Funatani, H., et al. Cyclic dipeptides exhibit potency for scavenging radicals Bioorg. Med. Chem. 20(6),2002-2009(2012).
4. Naim, M., Nir, S., Spielman, A.I., et al. Hypothesis of receptor-
5. Zubare-Samuelov, M., Peri, I., Tal, M., et al. Some sweet and bitter tastants stimulate inhibitory pathway of adenylyl cyclase via melatonin and α2-
cyclo(L-leucyl-L-tryptophyl) Preparation Products And Raw materials
Raw materials
Preparation Products
cyclo(L-leucyl-L-tryptophyl) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19905 | 58 |
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| LEON (NANJING) BIOTECHNOLOGY CO., LTD. | 15051830413 | sales.njleonbiotech@gmail.com | China | 5482 | 58 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Avantpbc Chemical Tech(Shanghai) Co,Ltd. | 17802107445 | China | 185 | 55 | |
| Nanjing Leon Biological Technology Co., Ltd. | 025-84523390 -127; 17705183659 | sales@njleonbiotech.com | China | 5501 | 55 |
| Nanjing Peptide Biotech Ltd. | 025-58361106-805 15951641583 | zhao.xu@njpeptide.com | China | 9976 | 55 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7858 | 58 |
