CYCLO(-LEU-PRO)
- CAS No.
- 2873-36-1
- Chemical Name:
- CYCLO(-LEU-PRO)
- Synonyms
- gancidinw;c(Leu-Pro);Maculosin 6;Cyclo(Pro-Leu);CYCLO(-LEU-PRO);cyclo-l-leu-l-pro;Cyclo(L-Pro-D-Leu);Cyclo(L-Pro-L-Leu-);Cyclo(proline-leucine);Cyclo-L-prolyl-L-leucine
- CBNumber:
- CB4142038
- Molecular Formula:
- C11H18N2O2
- Molecular Weight:
- 210.27
- MDL Number:
- MFCD00237617
- MOL File:
- 2873-36-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Cyclo(L-Pro-L-Leu) | C3973 | 10MG | $102 |
| Cyclo(L-Leu-L-Pro) ≥95% | 24941 | 5mg | $128 |
| Cyclo(L-Leu-L-Pro) ≥95% | 24941 | 25mg | $383 |
| Cyclo(L-prolyl-L-leucyl) | C987660 | 25mg | $425 |
| CYCLO(L-LEU-L-PRO) 95.00% | PEP0007072 | 5MG | $650 |
| More product size | |||
| Melting point | 163-165℃ |
|---|---|
| Boiling point | 427.6±34.0 °C(Predicted) |
| Density | 1.14 |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.27±0.40(Predicted) |
| color | White to Off-White |
| FDA UNII | KQV8MY059B |
CYCLO(-LEU-PRO) price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C3973 | Cyclo(L-Pro-L-Leu) | 2873-36-1 | 10MG | $102 | 2025-07-31 | Buy |
| Cayman Chemical | 24941 | Cyclo(L-Leu-L-Pro) ≥95% | 2873-36-1 | 5mg | $128 | 2024-03-01 | Buy |
| Cayman Chemical | 24941 | Cyclo(L-Leu-L-Pro) ≥95% | 2873-36-1 | 25mg | $383 | 2024-03-01 | Buy |
| TRC | C987660 | Cyclo(L-prolyl-L-leucyl) | 2873-36-1 | 25mg | $425 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PEP0007072 | CYCLO(L-LEU-L-PRO) 95.00% | 2873-36-1 | 5MG | $650 | 2021-12-16 | Buy |
CYCLO(-LEU-PRO) Chemical Properties,Uses,Production
Description
Cyclo(L-Leu-L-Pro) is a diketopiperazine metabolite that has been isolated from various bacterial and fungal species including Streptomyces. It is active against twelve strains of vancomycin-resistant enterococci (VRE) with MIC values of 12.5 μg/ml for E. faecalis strains K-99-34, K-00-184, and K-00-221. It also inhibits growth of K562, HL-60, and U937 leukemia cells in a concentration-dependent manner when used at concentrations of 1-500 μg/ml. Cyclo(L-Leu-L-Pro) also has antifouling activity, inhibiting attachment of B. amphitrite larva with an EC50 value of 0.15 mM.
Chemical Properties
White Solid
Uses
Sorbicillin analog. A bioactive secondary metabolites from terrestrial Streptomyces species TN262.
Definition
ChEBI: A homodetic cyclic peptide composed from leucyl and prolyl residues.
References
[1] RHEE K H. Isolation and characterization of Streptomyces sp KH-614 producing anti-VRE (vancomycin-resistant enterococci) antibiotics.[J]. Journal of General and Applied Microbiology, 2002, 48 6: 321-327. DOI: 10.2323/jgam.48.321
[2] XIANCUI LI. Antifouling diketopiperazines produced by a deep-sea bacterium, Streptomyces fungicidicus.[J]. Biofouling, 2006, 22 3-4: 201-208.
CYCLO(-LEU-PRO) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19908 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9644 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39035 | 58 |
View Lastest Price from CYCLO(-LEU-PRO) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-27 | Cyclo(L-Leu-L-Pro)
2873-36-1
|
US $40.00-138.00 / mg | 100.00% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-10-25 | Cyclo(L-Leu-L-Pro)
2873-36-1
|
US $40.00-138.00 / mg | 100.00% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-07-06 | CYCLO(-LEU-PRO)
2873-36-1
|
US $1.00 / kg | 1kg | 99% | Customized | Career Henan Chemical Co |
-
- Cyclo(L-Leu-L-Pro)
2873-36-1
- US $40.00-138.00 / mg
- 100.00%
- TargetMol Chemicals Inc.
-
- Cyclo(L-Leu-L-Pro)
2873-36-1
- US $40.00-138.00 / mg
- 100.00%
- TargetMol Chemicals Inc.
-
- CYCLO(-LEU-PRO)
2873-36-1
- US $1.00 / kg
- 99%
- Career Henan Chemical Co
