3-HYDRAZINO-QUINOXALINE-2-THIOL
- CAS No.
- 13080-21-2
- Chemical Name:
- 3-HYDRAZINO-QUINOXALINE-2-THIOL
- Synonyms
- AKOS BBS-00008251;CHEMBRDG-BB 5215319;3-Hydrazinylquinoxaline-2-thiol;3-HYDRAZINO-QUINOXALINE-2-THIOL;3-Hydrazinylquinoxaline-2(1H)-thione;2(1H)-Quinoxalinethione, 3-hydrazinyl-;3-hydrazinoquinoxaline-2-thiol(SALTDATA: FREE);membranes,Helicobacter,ulcer,Antimicrobial,gastric,HPi1,inhibit,Inhibitor,Bacterial,permeate,HPi 1,HPi-1,orally,pylori,peptic
- CBNumber:
- CB1135666
- Molecular Formula:
- C8H8N4S
- Molecular Weight:
- 192.24
- MDL Number:
- MFCD00457014
- MOL File:
- 13080-21-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H370 |
| Precautionary statements | P501-P260-P270-P264-P308+P311-P405 |
3-HYDRAZINO-QUINOXALINE-2-THIOL price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | H954603 | 3-Hydrazinylquinoxaline-2-thiol | 13080-21-2 | 250mg | $310 | 2021-12-16 | Buy |
| ChemScene | CS-0078290 | HPi1 ≥98.0% | 13080-21-2 | 5mg | $320 | 2021-12-16 | Buy |
| AK Scientific | 6386CD | 3-Hydrazinoquinoxaline-2-thiol | 13080-21-2 | 500mg | $386 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0984007 | 3-HYDRAZINO-2-QUINOXALINETHIOL 95.00% | 13080-21-2 | 5MG | $496.43 | 2021-12-16 | Buy |
| ChemBridge Corporation | BB-5215319 | 3-hydrazinoquinoxaline-2-thiol 95% | 13080-21-2 | 1g | $235 | 2021-12-16 | Buy |
3-HYDRAZINO-QUINOXALINE-2-THIOL Chemical Properties,Uses,Production
Uses
HPi1 is a potent, selective and orally active antimicrobial against Helicobacter pylori with an IC50 of 0.24 μM and an MIC of 0.08-0.16 μg/mL. HPi1 is inactive against other bacteria, including the gut commensals Lactobacillus casei, Lactobacillus reuteri, and Bifidobacterium longum[1].
Biological Activity
HPi1 is a potent, selective and orally active antibacterial agent against Helicobacter pylori with IC50 of 0.24 μM and MIC of 0.08-0.16 μg/mL. It is inactive against other bacteria, including the enteric bacteria Lactobacillus casei, Lactobacillus reuteri and Bifidobacterium longum.
in vitro
The MIC against H. pylori isolates ranged from 0.002-0.032 μg/mL (0.01-0.17 μM) in the agar dilution assay. HPi1 is effective against the clarithromycin-resistant strains ARHp172 (MIC of 0.004–0.016 μg/mL) and ARHp246 (MIC of 0.008–0.032 μg/mL).
HPi1 has some activity against the Bacteroides species , but at concentrations at least 18- fold higher than the H. pylori MIC. More potent activity is detected for Campylobacter jejuni with an MIC of 0.3 μg/mL.
HPi1 has good physicochemical and pharmacological properties, including determining the aqueous solubility (19 μg/mL), human plasma protein binding (93% bound), stability with human liver microsomes (T 1/2 of 1.3 hours) and the ability to passively permeate membranes.
in vivo
HPi1 (6.25-50 mg/kg; Oral gavage; once a day; for 3 days; female C57BL/6 mice) treatment decreases colony counts below the limit of detection at doses of 25 or 50 mg/kg/day[1].
| Animal Model: | Adult specific-pathogen-free female C57BL/6 mice (6-8-week-old) fed with H. pylori SS1 suspension[1] |
| Dosage: | 6.25 mg/kg, 12.5 mg/kg, 25 mg/kg, 50 mg/kg |
| Administration: | Oral gavage; once a day; for 3 days |
| Result: | Reduced colony counts to below the limit of detection. |
target
IC50: 0.24 μM ( Helicobacter pylori )
MIC: 0.08-0.16 μg/mL ( Helicobacter pylori )
References
[1] Gavrish E, et al. In vitro and in vivo activities of HPi1, a selective antimicrobial against Helicobacter pylori. Antimicrob Agents Chemother. 2014 Jun;58(6):3255-60. DOI:10.1128/AAC.02573-13
3-HYDRAZINO-QUINOXALINE-2-THIOL Preparation Products And Raw materials
Raw materials
Preparation Products
3-HYDRAZINO-QUINOXALINE-2-THIOL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32431 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9171 | 60 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Henan Weituxi Chemical Technology Co., Ltd. | 0371-0371-63284658 18135795563 | 2885349392@qq.com | China | 9992 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29770 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62320 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24989 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 17801761073 | Gsiyu@solarbio.com | China | 50464 | 58 |
