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TNP 351

TNP 351 Structure
TNP 351 structure
CAS No.
125991-51-7
Chemical Name:
TNP 351
Synonyms
TNP 351;N-[4-[3-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-L-glutamic acid;L-Glutamic acid, N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-
CBNumber:
CB11399317
Molecular Formula:
C21H24N6O5
Molecular Weight:
440.45
MDL Number:
MFCD00887508
MOL File:
125991-51-7.mol
MSDS File:
SDS
Last updated:2026-05-11 19:39:08
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TNP 351 Properties

FDA UNII 48GO5ZA420

TNP 351 Chemical Properties, Uses, Production

Uses

TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo[1].

References

[1] F Itoh ,et al. Novel pyrrolo[2,3-d]pyrimidine Antifolate TNP-351: Cytotoxic Effect on Methotrexate-Resistant CCRF-CEM Cells and Inhibition of Transformylases of De Novo Purine Biosynthesis. Cancer Chemother Pharmacol. 1994;34(4):273-9. DOI:10.1007/BF00686032

TNP 351 synthesis

125991-50-6
125991-51-7
Synthesis of TNP 351 from (S)-diethyl 2-(4-(3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl)benzamido)pentanedioate(WXG01255)

TNP 351 Preparation Products And Raw materials

Raw materials

(S)-diethyl 2-(4-(3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl)benzamido)pentanedioate(WXG01255) 4-Formyl-benzoic acid mono tert-butyl ester

Preparation Products

TNP 351 Suppliers

Global Suppliers ( 7)
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6288 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 27626 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 11975 58
TargetMol Chemicals Inc. 13564774135 marketing@targetmol.com United States 19950 58
Supplier Advantage
TargetMol Chemicals Inc. 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Nanjing Shizhou Biology Technology Co.,Ltd 58
TargetMol Chemicals Inc. 58

View Latest Price from TNP 351 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TNP-351 pictures 2026-05-11 TNP-351
125991-51-7
 $3750.00-8350.00 10g TargetMol Chemicals Inc.
  • TNP-351 pictures
  • TNP-351
    125991-51-7
  • $3750.00-8350.00
  • TargetMol Chemicals Inc.

125991-51-7 (TNP 351) Related Search:

5-Methyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine 4-n-Butylbenzylamine 4-n-Butylbenzamide CHEMBRDG-BB 9071952 CHEMBRDG-BB 9071517
TNP 351 4-Amino-7H-pyrrolo[2,3-d]pyrimidine CHEMBRDG-BB 9071469

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TNP 351 N-[4-[3-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-L-glutamic acid L-Glutamic acid, N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]- 125991-51-7