1-Amino-2-methylpropan-2-ol
- CAS No.
- 2854-16-2
- Chemical Name:
- 1-Amino-2-methylpropan-2-ol
- Synonyms
- 1-Amino-2-methyl-2-propanol;EOS-60808;NSC 17697;1-amino-2-methyL;TIANFU-CHEM 2854-16-2;2-Hydroxyisobutylamine;1,1-Dimethylethanolamine;-Amino-2-methylpropan-2-ol;2-Amino-a,a-dimethylethanol;1-Amino-2-methylpropan-2-ol
- CBNumber:
- CB11454713
- Molecular Formula:
- C4H11NO
- Molecular Weight:
- 89.14
- MDL Number:
- MFCD01697283
- MOL File:
- 2854-16-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 8.72°C (estimate) |
|---|---|
| Boiling point | 151°C(lit.) |
| Density | 1.915 g/mL at 25 °C |
| refractive index | n20/D1.448 |
| Flash point | 73℃ |
| storage temp. | 2-8°C |
| solubility | Chloroform, Ethyl Acetate (Slightly) |
| form | Oil |
| pka | 12.99±0.50(Predicted) |
| color | Clear Colourless |
| InChI | InChI=1S/C4H11NO/c1-4(2,6)3-5/h6H,3,5H2,1-2H3 |
| InChIKey | LXQMHOKEXZETKB-UHFFFAOYSA-N |
| SMILES | C(N)C(C)(O)C |
| CAS DataBase Reference | 2854-16-2 |
| EWG's Food Scores | 1 |
| NIST Chemistry Reference | 1-Amino-2-methyl-2-propanol(2854-16-2) |
| UNSPSC Code | 12352200 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P304+P340+P312-P305+P351+P338+P310 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-37/38-41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| RIDADR | 1993 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UA6125000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2922190090 | |||||||||
| Storage Class | 10 - Combustible liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
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| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
1-Amino-2-methylpropan-2-ol price More Price(80)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS007515 | 1-Amino-2-methylpropan-2-ol AldrichCPR | 2854-16-2 | 1g | $230 | 2026-04-30 | Buy |
| Sigma-Aldrich | 777625 | 1-Amino-2-methyl-2-propanol 95% anhydrous basis | 2854-16-2 | 1g | $128 | 2026-04-30 | Buy |
| TCI Chemical | A2442 | 1-Amino-2-methyl-2-propanol >98.0%(GC) | 2854-16-2 | 1g | $71 | 2026-04-30 | Buy |
| TCI Chemical | A2442 | 1-Amino-2-methyl-2-propanol >98.0%(GC) | 2854-16-2 | 5g | $205 | 2026-04-30 | Buy |
| Usbiological | 260062 | 1-Amino-2-methyl-propan-2-ol Asreported | 2854-16-2 | 1g | $326 | 2026-06-03 | Buy |
1-Amino-2-methylpropan-2-ol Chemical Properties, Uses, Production
Chemical Properties
Pale yellow liquid
Uses
3-Amino-2-methyl-2-propanol, is a versatile intermediate used for the synthesis of more complex compounds, including inhibitors. It is an intermediate in the preparation of metabolites of Darunavir (D193500), such as (A581405).
Synthesis
75-86-5
2854-16-2
The general procedure for the synthesis of 1-amino-2-methyl-2-propanol from acetone cyanohydrin is as follows: Step A: Synthesis of 1-amino-2-methyl-2-propanol [Chem.17] To a tetrahydrofuran (180 mL) suspension of lithium aluminum hydride (6.08 g, 160 mmol), a tetrahydrofuran (20 mL) solution of acetone cyanohydrin (7.32 mL, 80.0 mmol) was slowly added dropwise over a controlled period of 15 min at 0 °C. The reaction mixture was then refluxed for 4 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and the reaction was quenched with sodium sulfate decahydrate and potassium fluoride. After continued stirring at 35°C for 30 minutes, the mixture was filtered through a diatomaceous earth pad. The filtrate was concentrated in vacuum to give the oily product 1-amino-2-methyl-2-propanol (3.98 g, 56% yield). [0229] 1H-NMR (300 MHz, CDCl3) δ: 2.60 (s, 2H), 1.69 (s, 6H), no peaks for OH and NH2 were observed.
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 9, p. 4336 - 4351
[2] Patent: WO2010/84767, 2010, A1. Location in patent: Page/Page column 50-51
[3] Tetrahedron Letters, 1996, vol. 37, # 40, p. 7319 - 7322
[4] Journal of Medicinal Chemistry, 1998, vol. 41, # 18, p. 3347 - 3359
[5] Patent: EP1591446, 2005, A1. Location in patent: Page/Page column 96
1-Amino-2-methylpropan-2-ol Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai yirong biology science and technology co., ltd | 18049974220 | 3060526242@qq.com | China | 999 | 60 |
| BTC Pharmaceutical CO. Ltd | +86-15716293042 15716293042 | info@btcpharm.com | China | 822 | 55 |
| JInan Carbon Spring New Materials Co., Ltd. | 13658618215 | 308410472@qq.com | China | 58 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Latest Price from 1-Amino-2-methylpropan-2-ol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | 1-Amino-2-methylpropan-2-ol
2854-16-2
|
100g | 97% | 500g 1kg 5kg 10kg 25kg 50kg... | Zjartspharm Co., Ltd | ||
 |
2026-03-20 | 1-Amino-2-methylpropan-2-ol
2854-16-2
|
$10.00 | 1kg | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2024-02-26 | 1-Amino-2-methylpropan-2-ol
2854-16-2
|
1kg | 98% | BTC Nantong Pharmaceuticals Technology Co.,Ltd |
-
- 1-Amino-2-methylpropan-2-ol
2854-16-2
- $0.00
- 97%
- Zjartspharm Co., Ltd
-
- 1-Amino-2-methylpropan-2-ol
2854-16-2
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 1-Amino-2-methylpropan-2-ol
2854-16-2
- 98%
- BTC Nantong Pharmaceuticals Technology Co.,Ltd
