Benzo[h]quinoline-2-methanamine, N-(4-methoxyphenyl)-4-[(4-methoxyphenyl)amino]-
- CAS No.
- 3036109-10-8
- Chemical Name:
- Benzo[h]quinoline-2-methanamine, N-(4-methoxyphenyl)-4-[(4-methoxyphenyl)amino]-
- Synonyms
- Benzo[h]quinoline-2-methanamine, N-(4-methoxyphenyl)-4-[(4-methoxyphenyl)amino]-
- CBNumber:
- CB114684776
- Molecular Formula:
- C28H25N3O2
- Molecular Weight:
- 435.52
- MDL Number:
- MOL File:
- 3036109-10-8.mol
- MSDS File:
- SDS
Benzo[h]quinoline-2-methanamine, N-(4-methoxyphenyl)-4-[(4-methoxyphenyl)amino]- price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1012325 | SDU-071 98.75% | 3036109-10-8 | 5mg | $208 | 2026-06-04 | Buy |
| ChemScene | CS-1012325 | SDU-071 98.75% | 3036109-10-8 | 10mg | $312 | 2026-06-04 | Buy |
| ChemScene | CS-1012325 | SDU-071 98.75% | 3036109-10-8 | 25mg | $538 | 2026-06-04 | Buy |
| ACHEMBLOCK | AD279638 | SDU-071 98% | 3036109-10-8 | 5MG | $185 | 2026-05-27 | Buy |
| ACHEMBLOCK | AD279638 | SDU-071 98% | 3036109-10-8 | 25MG | $475 | 2026-05-27 | Buy |
Benzo[h]quinoline-2-methanamine, N-(4-methoxyphenyl)-4-[(4-methoxyphenyl)amino]- Chemical Properties, Uses, Production
Uses
SDU-071 is a potent and orally active inhibitor of BRD4-p53 inhibitor. SDU-071 inhibits MDA-MB-231 cells proliferation with an IC50 of 10.5 μM. SDU-071 induces cell cycle arrest and apoptosis[1].
in vivo
SDU-071 (250 mg/kg for i.g; once daily for 21 days) inhibits tumor growth in a MDA-MB-231 orthotopic mouse xenograft mammary tumor model[1].
| Animal Model: | DA-MB-231 Orthotopic Mouse Xenograft Mammary Tumor Model[1] |
| Dosage: | 50 and 250 mg/kg; Once daily for 21 days |
| Administration: | Gavage administration (i.g.) |
| Result: | Significantly inhibited tumor growth with 49.1% inhibition. Reduced the Protein levels for BRD4, Mucin5AC, c-Myc, CDK4, and CDK6, upregulated the p21 protein. |
References
[1] Wang S, et al. Novel BRD4-p53 Inhibitor SDU-071 Suppresses Proliferation and Migration of MDA-MB-231 Triple-Negative Breast Cancer Cells[J]. ACS Pharmacology & Translational Science, 2024.
Benzo[h]quinoline-2-methanamine, N-(4-methoxyphenyl)-4-[(4-methoxyphenyl)amino]- Preparation Products And Raw materials
Raw materials
Preparation Products
Benzo[h]quinoline-2-methanamine, N-(4-methoxyphenyl)-4-[(4-methoxyphenyl)amino]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696,15000506266 15000506266 | China | 4860 | 55 | |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| Wuhan Shanhai Zhihe Biotechnology Co., Ltd. | 17771424646 | shoubull@126.com | China | 892 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 7283 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| TargetMol | 400-821-0310 15002144251 | xuexiang.shao@tsbiochem.com | China | 29128 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32997 | 60 |




