3,5-Difluoro-4-pyridinecarboxaldehyde
- CAS No.
- 870234-98-3
- Chemical Name:
- 3,5-Difluoro-4-pyridinecarboxaldehyde
- Synonyms
- 2,6-difluoroisonicotinaldehyde;3,5-Difluoroisonicotinaldehyde 98%;3,5-Difluoro-4-pyridinecarboxaldehyde;4-Pyridinecarboxaldehyde, 3,5-difluoro-;3,5-difluoropyridine-4-carbaldehyde - [D87647];(5-fluoro-4-(methylsulfonyl)pyridin-3-yl)boronic acid;3,5-Difluoro-4-pyridinecarboxaldehyde ISO 9001：2015 REACH;3,5-Difluoropyridine-4-carboxaldehyde, 3,5-Difluoro-4-formylpyridine;3,5-Difluoropyridine-4-carboxaldehyde 3,5-Difluoro-4-pyridinecarboxaldehyde
- CBNumber:
- CB11501367
- Molecular Formula:
- C6H3F2NO
- Molecular Weight:
- 143.09
- MDL Number:
- MFCD07368235
- MOL File:
- 870234-98-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 51-52℃ |
|---|---|
| Boiling point | 169℃ |
| Density | 1.392 |
| Flash point | 56℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -1.60±0.28(Predicted) |
| Appearance | Light yellow to yellow Solid |
| InChI | InChI=1S/C6H3F2NO/c7-5-1-9-2-6(8)4(5)3-10/h1-3H |
| InChIKey | RLAOKDGTZKSUJB-UHFFFAOYSA-N |
| SMILES | C1=NC=C(F)C(C=O)=C1F |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| HS Code | 2933399990 |
3,5-Difluoro-4-pyridinecarboxaldehyde price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC7022 | 3,5-Difluoroisonicotinaldehyde 98% | 870234-98-3 | 1g | $267 | 2026-06-04 | Buy |
| Apolloscientific | PC7022 | 3,5-Difluoroisonicotinaldehyde 98% | 870234-98-3 | 5g | $823 | 2026-06-04 | Buy |
| Activate Scientific | AS46822 | 3,5-Difluoroisonicotinaldehyde 98% | 870234-98-3 | 1g | $298 | 2026-06-04 | Buy |
| Activate Scientific | AS46822 | 3,5-Difluoroisonicotinaldehyde 98% | 870234-98-3 | 5g | $871 | 2026-06-04 | Buy |
| Matrix Scientific | 307117 | 3,5-Difluoroisonicotinaldehyde | 870234-98-3 | 250.00mg | $63 | 2026-05-19 | Buy |
3,5-Difluoro-4-pyridinecarboxaldehyde Chemical Properties,Uses,Production
Uses
3,5-Difluoropyridine-4-carboxaldehyde is an aldehyde organic compound that can be used as a pharmaceutical intermediate.
Synthesis
107-31-3
71902-33-5
870234-98-3
General procedure for the synthesis of 3,5-difluoropyridine-4-carbaldehyde from methyl formate and 3,5-difluoropyridine: Preparation of Example 10: N-[(3,5-difluoro-4-pyridinyl)methyl]-2-(trifluoromethyl)pyridine-3-carboxamide (Compound A126) Step 1: Synthesis of 3,5-difluoropyridine-4-carbaldehyde A 2M solution of LDA (47.792 mL, 95.58 mmol) was diluted with 50 mL of THF at 0°C and cooled to -78°C. Subsequently, a 100 mL THF solution of 3,5-difluoropyridine (7.886 mL, 86.89 mmol) was added dropwise, keeping the temperature lower than -70°C (the dropwise addition process was controlled to be completed within 20 min). The reaction mixture formed a yellow suspension. Stirring was continued at -78°C for 3 hours. Then, 25 mL of THF solution of methyl formate (10.8 mL, 173.79 mmol) was added and the reaction mixture was transformed into a light yellow solution and stirred at -75°C for 45 minutes. The reaction mixture was transferred by cannula to 100 mL of stirred saturated aqueous NaHCO3 solution, maintained at about 0°C. The solution was extracted with EtOAc, the organic phases were combined and washed with brine and dried with 1N HCl. The solvent was evaporated at 165 mbar, 30°C to give 36.7 g of yellow liquid crude product. The crude product was purified by fast chromatography (eluent: CH2Cl2) to give a light yellow oil (7.85 g), which was crystallized after standing. 1H-NMR (CDCl3) data: δ 10.4 (s, 1H), 8.57 (s, 2H).
References
[1] Patent: US2014/128386, 2014, A1. Location in patent: Paragraph 1410; 1411; 1412; 1413; 1414
[2] Patent: US2017/57954, 2017, A1. Location in patent: Paragraph 0630; 0631; 0632; 0633; 0634
[3] Patent: US2009/286800, 2009, A1. Location in patent: Page/Page column 107-108
[4] Patent: WO2013/64521, 2013, A1. Location in patent: Page/Page column 112
[5] Patent: US2017/217954, 2017, A1
3,5-Difluoro-4-pyridinecarboxaldehyde Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Chengqian Pharmaceutical Technology Co., Ltd. | 025-52791040 18652036685 | haozhongwen@126.com | China | 875 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai AmasPharm Co., Ltd. | 021-54540637 18621091017 | sales@amaspharm.com | China | 787 | 62 |
| ZhengZhou HuaWen Chemical Co.Ltd | 0370-2785118 17550508557 | 675141927@qq.com | China | 3201 | 55 |
| Heterochem | 027-88041443 13072715837 | sales@hetero-chem.com | China | 695 | 58 |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| Shanghai Hong-chuang Pharma Tech Co., Ltd. | 18151128828 | hc-sales@foxmail.com | China | 2635 | 55 |
View Lastest Price from 3,5-Difluoro-4-pyridinecarboxaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-25 | 3,5-Difluoro-4-pyridinecarboxaldehyde
870234-98-3
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-12-25 | 3,5-Difluoro-4-pyridinecarboxaldehyde
870234-98-3
|
$2.00 | 1KG | 98%MIN | Career Henan Chemical Co |
-
- 3,5-Difluoro-4-pyridinecarboxaldehyde
870234-98-3
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 3,5-Difluoro-4-pyridinecarboxaldehyde
870234-98-3
- $2.00
- 98%MIN
- Career Henan Chemical Co
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