2'',3''-Dihydro-2''-oxospiro-[piperidine-4,4''(1H'')-quinazoline
- CAS No.
- 635713-68-7
- Chemical Name:
- 2'',3''-Dihydro-2''-oxospiro-[piperidine-4,4''(1H'')-quinazoline
- Synonyms
- 1'H-Spiro[piperidine-4,4'-quinazolin]-2'(3'H)-one;Spiro[piperidine-4,4'(1'H)-quinazolin]-2'(3'H)-one;spiro[1,3-dihydroquinazoline-4,4'-piperidine]-2-one;1'H-spiro[piperidine-4,4'(1'H)-quinazolin]-2'(3'H)-one;2'',3''-Dihydro-2''-oxospiro-[piperidine-4,4''(1H'')-quinazoline
- CBNumber:
- CB11516769
- Molecular Formula:
- C12H15N3O
- Molecular Weight:
- 217.27
- MDL Number:
- MFCD11045505
- MOL File:
- 635713-68-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
2'',3''-Dihydro-2''-oxospiro-[piperidine-4,4''(1H'')-quinazoline price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 119022 | 1'H-Spiro[piperidine-4,4'-quinazolin]-2'(3'H)-one | 635713-68-7 | 250.00mg | $490 | 2026-05-18 | Buy |
| Matrix Scientific | 119022 | 1'H-Spiro[piperidine-4,4'-quinazolin]-2'(3'H)-one | 635713-68-7 | 1.00g | $1224 | 2026-05-18 | Buy |
| aablocks | AA00EIT4 | 1'H-Spiro[piperidine-4,4'-quinazolin]-2'(3'H)-one 96% | 635713-68-7 | 100mg | $140 | 2026-05-28 | Buy |
| aablocks | AA00EIT4 | 1'H-Spiro[piperidine-4,4'-quinazolin]-2'(3'H)-one 96% | 635713-68-7 | 250mg | $207 | 2026-05-28 | Buy |
| aablocks | AA00EIT4 | 1'H-Spiro[piperidine-4,4'-quinazolin]-2'(3'H)-one 96% | 635713-68-7 | 1g | $507 | 2026-05-28 | Buy |
2'',3''-Dihydro-2''-oxospiro-[piperidine-4,4''(1H'')-quinazoline Chemical Properties, Uses, Production
Synthesis
![Spiro[piperidine-4,4'(1'H)-quinazolin]-2'(3'H)-one, 1-(phenylmethyl)-](/CAS/20210305/GIF/635713-67-6.gif)
635713-67-6
635713-68-7
The general procedure for the synthesis of 1'H-spiro[piperidine-4,4'-quinazolin]-2'(3'H)-ones was carried out as follows, using 1-benzyl-1'H-spiro[piperidine-4,4'-quinazolin]-2'(3'H)-ones as starting material: 1-benzyl-1'H-spiro[piperidine-4,4'-quinazolin]-2'(3'H)-ones (1.00 g) were dissolved in degassed methanol (50 ml ), 6N hydrochloric acid (2.0 ml) was added followed by 10% palladium carbon catalyst (150 mg). The reaction mixture was placed in a Parr hydrogenation unit and the reaction was shaken at 60 psi hydrogen pressure overnight. The progress of the reaction was monitored by LC/MS and the reaction was found to be incomplete. The 10% palladium carbon catalyst (200 mg) was added additionally and the reaction was continued with oscillation under the same conditions for 2 days. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford the target product 1'H-spiro[piperidin-4,4'-quinazolin]-2'(3'H)-one (531 mg, 64% yield). Mass spectrometry analysis showed a molecular ion peak of 218.12 (MH+).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 14, p. 4719 - 4722
[2] Patent: WO2003/104236, 2003, A1. Location in patent: Page 58
[3] Patent: US2005/215576, 2005, A1. Location in patent: Page/Page column 19
2'',3''-Dihydro-2''-oxospiro-[piperidine-4,4''(1H'')-quinazoline Preparation Products And Raw materials
Raw materials
Preparation Products
2'',3''-Dihydro-2''-oxospiro-[piperidine-4,4''(1H'')-quinazoline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Cuisen Pharmaceutical Technology Co., Ltd. | 13472757003 | yongnan.wang@cendrix.cn | China | 974 | 65 |
| Shanghai Witofly Chemical Co.,Ltd | sales@witofly.com | China | 2853 | 52 | |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Zhengzhou Alfachem Co., Ltd. | 0371-53765687 18937137882 | 3969243885@qq.com | China | 7734 | 55 |
| Shanghai Wuping Biological Technology Co., Ltd. | 18501609135 | 182517690@qq.com | China | 237 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| 9ding chemical ( Shanghai) Limited | 021-021-52271985 17721149837 | sales@9dingchem.com | China | 19780 | 60 |
| Sichuan BoYou Biotechnology Co., Ltd. | 028-65791793 18140026355 | 568470422@qq.com | China | 9961 | 58 |
