5-Aminoindan
- CAS No.
- 24425-40-9
- Chemical Name:
- 5-Aminoindan
- Synonyms
- Aminoindan;AKOS 91137;5-AMINOINDAN;5-INDANAMINE;indan-5-amine;5-AMINOINDANE;5-Indanylamine;indan-5-ylamine;5-Aminoindan,97%;5-AMinoindan 95%
- CBNumber:
- CB1160736
- Molecular Formula:
- C9H11N
- Molecular Weight:
- 133.19
- MDL Number:
- MFCD00003803
- MOL File:
- 24425-40-9.mol
- MSDS File:
- SDS
| Melting point | 34-36 °C(lit.) |
|---|---|
| Boiling point | 247-249 °C745 mm Hg(lit.) |
| Density | 0.9222 (rough estimate) |
| refractive index | 1.4600 (estimate) |
| Flash point | >230 °F |
| storage temp. | 0-10°C |
| pka | 5.17±0.20(Predicted) |
| form | Crystalline Solid |
| color | Brown |
| Water Solubility | SLIGHTLY SOLUBLE |
| BRN | 2082278 |
| InChI | InChI=1S/C9H11N/c10-9-5-4-7-2-1-3-8(7)6-9/h4-6H,1-3,10H2 |
| InChIKey | LEWZOBYWGWKNCK-UHFFFAOYSA-N |
| SMILES | C1C2=C(C=C(N)C=C2)CC1 |
| CAS DataBase Reference | 24425-40-9(CAS DataBase Reference) |
| FDA UNII | Y4Z93Y93WJ |
| NIST Chemistry Reference | 5-Aminoindan(24425-40-9) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22 | |||||||||
| Safety Statements | 36-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29214900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral |
|||||||||
| NFPA 704 |
|
5-Aminoindan price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 130877 | 5-Aminoindan 95% | 24425-40-9 | 10g | $123 | 2026-04-30 | Buy |
| TCI Chemical | A0991 | 5-Aminoindan >98.0%(GC)(T) | 24425-40-9 | 10g | $109 | 2026-04-30 | Buy |
| Usbiological | 258252 | 5-Aminoindane Asreported | 24425-40-9 | 10g | $333 | 2026-06-03 | Buy |
| Usbiological | 258252 | 5-Aminoindane Asreported | 24425-40-9 | 25g | $485 | 2026-06-03 | Buy |
| Usbiological | 258252 | 5-Aminoindane Asreported | 24425-40-9 | 50g | $665 | 2026-06-03 | Buy |
5-Aminoindan Chemical Properties, Uses, Production
Chemical Properties
brown crystalline mass
Uses
5-Aminoindan was used in the synthesis of ligand 18/18 (2-(5-aminoindan)-6-(5-aminoindan)-4-chloro-s-triazine).
Synthesis
41734-55-8
24425-40-9
General procedure for the synthesis of 5-aminoindan from 5-nitroindene: To a solution of EtOAc (20 mL) of 5-nitroindene (80.5 mg, 0.5 mmol) was added 10% Pd/C (catalyst dosage of 20% by mass of 5-nitroindene). The mixture was stirred overnight at room temperature in a hydrogen atmosphere. Upon completion of the reaction, the insoluble material was removed by filtration and washed with EtOAc. The filtrate was concentrated to dryness under reduced pressure to give 5-aminoindene (65 mg, 98% yield) as a brown oil. To a solution of 5-aminoindene (150 mg, 0.8 mmol) in thionyl chloride (4 mL) was added a drop of pyridine followed by reflux for 24 hours. At the end of the reaction, the thionyl chloride was removed by distillation to give 5-aminoindene chloride as a light yellow solid, and the product was used directly in the next step of the reaction. A dichloromethane (2 mL) solution of 5-aminoindene chloride was added dropwise to an anhydrous pyridine (2 mL) solution of 5-aminoindene (65 mg, 0.5 mmol) at 0°C. The mixture was stirred at room temperature for 7 h. Methanol was subsequently removed by distillation. The organic layer was treated sequentially with 1N HCl until acidic. The mixture was partitioned between water and EtOAc. The organic layer was washed with saturated brine, dried over anhydrous Na2SO4 and concentrated in vacuum. The residue was purified by silica gel column chromatography (eluent: hexane/EtOAc = 3/1) to afford the target compound 5-aminoindan (118 mg, 80% yield) as a light yellow solid. Melting point 138~142°C; 1H-NMR: δ8.15 (d, J=6.9Hz, 2H), 7.93 (d, J=8.1Hz, 2H), 7.60 (s, 1H), 7.30 (d, J=8.1Hz, 1H), 7.22 (d, J=7.9Hz, 1H), 3.96 (s, 3H), 2.95-2.89 (m. 4H), 2.13-2.07 (m, 2H); ESI-MS: m/z [M+H]+ 296.
Purification Methods
Distil the indane and then crystallise it from pet ether. [Beilstein 12 I 511, 12 III 2798.]
References
[1] Molecules, 2017, vol. 22, # 1,
[2] Justus Liebigs Annalen der Chemie, 1953, vol. 579, p. 133,151
[3] Journal of the Chemical Society, 1947, p. 95
5-Aminoindan Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianjin and Sinde Biotechnology Co., Ltd. | 15022315965; 18502259037 | sales_hxd@163.com | China | 385 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
View Latest Price from 5-Aminoindan manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-04-04 | 5-Aminoindan
24425-40-9
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2024-02-26 | 5-Aminoindan
24425-40-9
|
1kg | 98% | BTC Nantong Pharmaceuticals Technology Co.,Ltd | |||
 |
2021-08-12 | 5-Aminoindan
24425-40-9
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 5-Aminoindan
24425-40-9
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 5-Aminoindan
24425-40-9
- 98%
- BTC Nantong Pharmaceuticals Technology Co.,Ltd
-
- 5-Aminoindan
24425-40-9
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
