Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Fursultiamine

Fursultiamine

Fursultiamine Structure
Fursultiamine structure
CAS No.
804-30-8
Chemical Name:
Fursultiamine
Synonyms
ttfd;FURSULTIAMINE HYDROCHLORIDE;Fursutiamine;thiaminetetrahydrofurfuryldisulfide;judolor;linamin;Retar B1;adventan;diteftin;Alinaxin
CBNumber:
CB1161096
Molecular Formula:
C17H26N4O3S2
Molecular Weight:
398.54
MDL Number:
MFCD00867383
MOL File:
804-30-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Request For Quotation

Fursultiamine Properties

Melting point 130-136°C (decompos.)
Boiling point 652.3±55.0 °C(Predicted)
Density 1.29
refractive index 1.6270 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).
form Solid
pka 14.42±0.10(Predicted)
color White to Off-White
InChI InChI=1S/C17H26N4O3S2/c1-12(16(5-6-22)26-25-10-15-4-3-7-24-15)21(11-23)9-14-8-19-13(2)20-17(14)18/h8,11,15,22H,3-7,9-10H2,1-2H3,(H2,18,19,20)
InChIKey JTLXCMOFVBXEKD-UHFFFAOYSA-N
SMILES C(N(CC1=CN=C(C)N=C1N)C(C)=C(SSCC1CCCO1)CCO)=O
CAS DataBase Reference 804-30-8(CAS DataBase Reference)
FDA UNII 05J61265PX
NCI Drug Dictionary fursultiamine

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
Toxicity LD50 in rats (mg/kg): 2200 orally; 540 i.p. (Yurugi, Fushimi)

Fursultiamine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical F1364 Fursultiamine 804-30-8 5G $41 2026-04-30 Buy
TCI Chemical F1364 Fursultiamine 804-30-8 25G $141 2026-04-30 Buy
Cayman Chemical 33456 Fursultiamine ≥95% 804-30-8 10mg $107 2026-04-30 Buy
Cayman Chemical 33456 Fursultiamine ≥95% 804-30-8 25mg $160 2026-04-30 Buy
Cayman Chemical 33456 Fursultiamine ≥95% 804-30-8 50mg $292 2026-04-30 Buy
Product number Packaging Price Buy
F1364 5G $41 Buy
F1364 25G $141 Buy
33456 10mg $107 Buy
33456 25mg $160 Buy
33456 50mg $292 Buy

Fursultiamine Chemical Properties, Uses, Production

Description

Fursultiamine (syn. thiamine tetrahydrofurfuryl disulfide) is a vitamin B1 derivative which is rarely used, is only sparingly soluble in water and thus is usually employed only for solid drug forms. Lyophilisates are stabilized by sodium dextran sulfate.

Chemical Properties

white or slightly yellow crystalline powder. melting point 130-136 °C (decomposition). soluble in methanol, ethanol, chloroform, slightly soluble in acetone, insoluble in benzene, ether, slightly garlic odor.

Originator

Alinamin F,Takeda,Japan,1961

Uses

Fursultiamine is an oral source of thiamine, used in comparative pharmacokinectic analysis of thiamine and it’s phosphorylated metabolites administered as multivitamin preparations, identification of drug candidate against prostate cancer from aspect of somatic cell reprogramming, therapeutic tool in number of human neurological diseases.

Application

Fursultiamine, a lipophilic vitamin B1 derivative, which is more readily absorbed in large amounts in the small intestine and has a longer half-life than its active counterpart vitamin B1. It is suitable for the treatment of beriberi or Wernicke encephalopathy due to vitamin B1 deficiency. It can also be used for the adjuvant treatment of peripheral neuritis and indigestion caused by vitamin B1 deficiency.

Preparation

Furanthiamine is obtained by condensing thiamine hydrochloride with sodium tetrahydrofuranmethyl thiosulfate after ring opening.

Definition

ChEBI: Fursultiamine is a member of pyrimidines.

Manufacturing Process

To a solution of 20 parts of thiamine hydrochloride in 30 parts of water is added an aqueous solution of sodium hydroxide (7.2 parts of NaOH in 30 parts of water), and the mixture is cooled with water. The mixture is allowed to stand for 30 minutes, 60 parts of chloroform is added, followed by a solution of 30 parts of crude sodium tetrahydrofurfurylthiosulfate in 30 parts of water, and the whole is stirred for 30 minutes. The chloroform layer is separated and the aqueous layer is extracted twice with 20 parts of chloroform. All the chloroform solutions are combined and shaken with 50 parts of 5% hydrochloric acid. The acid solution is decolorized and neutralized with alkali carbonate, whereupon thiamine tetrahydrofurfuryl disulfide separates out in the resinous state but soon solidifies [MP 129°C (decamp.)] . The yield is 16 parts. Recrystallization from ethyl acetate gives colorless prisms melting at 132°C (decomp.).

Therapeutic Function

Enzyme cofactor vitamin

Fursultiamine Preparation Products And Raw materials

Raw materials

2-Acetylbutyrolactone Acrylonitrile Dimethyl sulfate Thiamine hydrochloride Sodium hydroxide

Preparation Products

Fursultiamine Suppliers

Global Suppliers ( 187)
Supplier Tel Email Country ProdList Advantage
Minsheng Group Shaoxing Pharmaceutical Co., Ltd. -- mssxyy@mspharm.com China 22 60
Taizhou Lingfeng Biotechnology Co., LTD. 00-17769775592 17769775592 liya@holibio.com China 10 58
Hubei Weideli Chemical Reagent Co., Ltd. 027-83984790 17720532645 t17720532645@163.com China 963 58
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
TargetMol Chemicals Inc. 021-021-33632979 15002134094 marketing@targetmol.com China 7993 58
Shanghai Synchem Pharma Co., ltd 21-619849051-1 18521059765 synchempharma@aliyun.com China 4988 55
Boen pharm 86 512-62572107 62962707 China 799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shandong Xiya Chemical Co., Ltd. 4009903999 13395398332 sales@xiyashiji.com China 20788 60
Supplier Advantage
Minsheng Group Shaoxing Pharmaceutical Co., Ltd. 60
Taizhou Lingfeng Biotechnology Co., LTD. 58
Hubei Weideli Chemical Reagent Co., Ltd. 58
Pure Chemistry Scientific Inc. 62
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
TargetMol Chemicals Inc. 58
Shanghai Synchem Pharma Co., ltd 55
Boen pharm 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shandong Xiya Chemical Co., Ltd. 60

View Latest Price from Fursultiamine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Fursultiamine pictures 2026-09-18 Fursultiamine
804-30-8
 25KG 99%min 1000kg WUHAN FORTUNA CHEMICAL CO., LTD
Fursultiamine HCL JP USP/EP/BP pictures 2026-08-20 Fursultiamine HCL JP USP/EP/BP
$1.10 1g 99.9% 100 Tons min Dideu Industries Group Limited
Fursultiamine pictures 2026-08-20 Fursultiamine
804-30-8
 $1.10 1g 99.0% Min 100 Tons Dideu Industries Group Limited
  • Fursultiamine pictures
  • Fursultiamine
    804-30-8
  • $1.10
  • 99.0% Min
  • Dideu Industries Group Limited

804-30-8 (Fursultiamine) Related Search:

Methanol Methylene dithiocyanate Methylparaben Paraquat dichloride DL-Dithiothreitol
Methyl acrylate Dimethyl disulfide Furan Kresoxim-methyl Selenium sulfide
Basic Violet 1 Acetonitrile Chlorophosphonazo III 2-Isopropyl-6-methyl-4-pyrimidinol Methyl
Fursultiamine HCL JP Thiamine chloride Thiamine disulfide

1of4

((tetrahydrofurfuryl)dithio)-1-butenyl)- adventan alinaminf diteftin fursultiamin n-(4-amino-2-methylpyrimidin-5-ylmethyl)-n-[4-hydroxy-1-methyl- 2-(tetrahydrofurfuryldithio)but-1-enyl]formamide Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[(tetrahydrofurfuryl)dithio]-1-butenyl]- (6CI, 8CI) Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-butenyl]- N-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[(tetrahydrofurfuryl)dithio]-1-butenyl]formamide Retar B1 Tetrahydrofurfuryl thiamine disulfide Thiamin tetrahydrofurfuryl disulfide N-[(4-amino-2-methyl-pyrimidin-5-yl)methyl]-N-[(E)-5-hydroxy-3-(oxolan-2-ylmethyldisulfanyl)pent-2-en-2-yl]formamide Fursultiamine (base and/or unspecified salts) N-(-4-amino-2-methyl-5-pyrimidinylmethyl)-N-(-4-hydroxyl-1-methyl-2-tetrahyclrofurfury(dithio-1-bute Fursultiamine###Fursultiamine Hcl FURSULTIAMINE Fursultiamine Base Fursultiaminlim N-(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-butenyl]forma Aliaron F Alinaxin N-[(2-Methyl-4-amino-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydrofuran-2-yl)methyl]dithio]-1-butenyl]formamide judolor linamin retar-b(sub1) Fursultiamine Hydrochloride RS Formamide, N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[4-hydroxy-1-methyl-2-[[(tetrahydro-2-furanyl)methyl]dithio]-1-buten-1-yl]- THIAMINE TETRAHYDROFURFURYL DISULFIDE (TTFD) Fursultiamine USP/EP/BP Fursultiamine HCL JP USP/EP/BP Derivative Fursultiamine N-((4-Amino-2-methylpyrimidin-5-yl)methyl)-N-(5-hydroxy-3-(((tetrahydrofuran-2-yl)methyl)disulfanyl)pent-2-en-2-yl)formamide Furan thiamine Fursultiamine, 10 mM in DMSO n-(4-amino-2-methylpyrimidin-5-ylmethyl)-n-[4-hydroxy-1-methyl- 2-(tetrahydrofurfuryldithio)but-1-enyl]formamid Fursutiamine FURSULTIAMINE HYDROCHLORIDE thiaminetetrahydrofurfuryldisulfide ttfd 804-30-8 C17H26N4O3S2 Vitamins and derivatives