Fursultiamine
- CAS No.
- 804-30-8
- Chemical Name:
- Fursultiamine
- Synonyms
- ttfd;FURSULTIAMINE HYDROCHLORIDE;Fursutiamine;thiaminetetrahydrofurfuryldisulfide;judolor;linamin;Retar B1;adventan;diteftin;Alinaxin
- CBNumber:
- CB1161096
- Molecular Formula:
- C17H26N4O3S2
- Molecular Weight:
- 398.54
- MDL Number:
- MFCD00867383
- MOL File:
- 804-30-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Fursultiamine | F1364 | 5G | $41 |
| Fursultiamine | F1364 | 25G | $141 |
| Fursultiamine ≥95% | 33456 | 10mg | $107 |
| Fursultiamine ≥95% | 33456 | 25mg | $160 |
| Fursultiamine ≥95% | 33456 | 50mg | $292 |
| More product size | |||
| Melting point | 130-136°C (decompos.) |
|---|---|
| Boiling point | 652.3±55.0 °C(Predicted) |
| Density | 1.29 |
| refractive index | 1.6270 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF). |
| form | Solid |
| pka | 14.42±0.10(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C17H26N4O3S2/c1-12(16(5-6-22)26-25-10-15-4-3-7-24-15)21(11-23)9-14-8-19-13(2)20-17(14)18/h8,11,15,22H,3-7,9-10H2,1-2H3,(H2,18,19,20) |
| InChIKey | JTLXCMOFVBXEKD-UHFFFAOYSA-N |
| SMILES | C(N(CC1=CN=C(C)N=C1N)C(C)=C(SSCC1CCCO1)CCO)=O |
| CAS DataBase Reference | 804-30-8(CAS DataBase Reference) |
| FDA UNII | 05J61265PX |
| NCI Drug Dictionary | fursultiamine |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
| Toxicity | LD50 in rats (mg/kg): 2200 orally; 540 i.p. (Yurugi, Fushimi) |
Fursultiamine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F1364 | Fursultiamine | 804-30-8 | 5G | $41 | 2026-04-30 | Buy |
| TCI Chemical | F1364 | Fursultiamine | 804-30-8 | 25G | $141 | 2026-04-30 | Buy |
| Cayman Chemical | 33456 | Fursultiamine ≥95% | 804-30-8 | 10mg | $107 | 2026-04-30 | Buy |
| Cayman Chemical | 33456 | Fursultiamine ≥95% | 804-30-8 | 25mg | $160 | 2026-04-30 | Buy |
| Cayman Chemical | 33456 | Fursultiamine ≥95% | 804-30-8 | 50mg | $292 | 2026-04-30 | Buy |
Fursultiamine Chemical Properties,Uses,Production
Description
Fursultiamine (syn. thiamine tetrahydrofurfuryl disulfide) is a vitamin B1 derivative which is rarely used, is only sparingly soluble in water and thus is usually employed only for solid drug forms. Lyophilisates are stabilized by sodium dextran sulfate.
Chemical Properties
white or slightly yellow crystalline powder. melting point 130-136 °C (decomposition). soluble in methanol, ethanol, chloroform, slightly soluble in acetone, insoluble in benzene, ether, slightly garlic odor.
Originator
Alinamin F,Takeda,Japan,1961
Uses
Fursultiamine is an oral source of thiamine, used in comparative pharmacokinectic analysis of thiamine and it’s phosphorylated metabolites administered as multivitamin preparations, identification of drug candidate against prostate cancer from aspect of somatic cell reprogramming, therapeutic tool in number of human neurological diseases.
Application
Fursultiamine, a lipophilic vitamin B1 derivative, which is more readily absorbed in large amounts in the small intestine and has a longer half-life than its active counterpart vitamin B1. It is suitable for the treatment of beriberi or Wernicke encephalopathy due to vitamin B1 deficiency. It can also be used for the adjuvant treatment of peripheral neuritis and indigestion caused by vitamin B1 deficiency.
Preparation
Furanthiamine is obtained by condensing thiamine hydrochloride with sodium tetrahydrofuranmethyl thiosulfate after ring opening.
Definition
ChEBI: Fursultiamine is a member of pyrimidines.
Manufacturing Process
To a solution of 20 parts of thiamine hydrochloride in 30 parts of water is added an aqueous solution of sodium hydroxide (7.2 parts of NaOH in 30 parts of water), and the mixture is cooled with water. The mixture is allowed to stand for 30 minutes, 60 parts of chloroform is added, followed by a solution of 30 parts of crude sodium tetrahydrofurfurylthiosulfate in 30 parts of water, and the whole is stirred for 30 minutes. The chloroform layer is separated and the aqueous layer is extracted twice with 20 parts of chloroform. All the chloroform solutions are combined and shaken with 50 parts of 5% hydrochloric acid. The acid solution is decolorized and neutralized with alkali carbonate, whereupon thiamine tetrahydrofurfuryl disulfide separates out in the resinous state but soon solidifies [MP 129°C (decamp.)] . The yield is 16 parts. Recrystallization from ethyl acetate gives colorless prisms melting at 132°C (decomp.).
Therapeutic Function
Enzyme cofactor vitamin
Fursultiamine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Natural Micron Pharm Tech Co.,LTD | +86-18653895227 | info@nmpharmtech.com | China | 94 | 58 |
| Wuhan Qiami Technology Co., Ltd | +8618062705058 | qiamichem@163.com | China | 140 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-86-13131129325 +8613131129325 | sales1@chuanghaibio.com | China | 5220 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 3106 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 | faith@widelychemical.com | CHINA | 742 | 58 |
View Lastest Price from Fursultiamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-28 | Fursultiamine
804-30-8
|
25KG | 99%min | 1000kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-07-27 | Fursultiamine
804-30-8
|
$35.00-98.00 | 99.90% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-15 | Fursultiamine
804-30-8
|
98% | 1000KGS | Zhengzhou Anbu Chem Co.,Ltd |
-
- Fursultiamine
804-30-8
- $0.00
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Fursultiamine
804-30-8
- $35.00-98.00
- 99.90%
- TargetMol Chemicals Inc.
-
- Fursultiamine
804-30-8
- $0.00
- 98%
- Zhengzhou Anbu Chem Co.,Ltd
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