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Thiamine disulfide

Thiamine disulfide structure

CAS No.: 67-16-3

Chemical Name:: Thiamine disulfide

Synonyms: TDS;SSB1;Daiomin;Apren S;Daisazin;Neolamin;Alitia S;FeidMin 5;BISTHIAMINE;Algoneurina

CBNumber:: CB9722783

Molecular Formula:: C24H34N8O4S2

Molecular Weight:: 562.71

MDL Number:: MFCD00010427

MOL File:: 67-16-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-22 18:57:36

Product description	Number	Pack Size	Price
Thiamine Disulfide Pharmaceutical Secondary Standard; Certified Reference Material	PHR2216	1 g	$639
Thiamine Disulfide Hydrate >98.0%(T)	T0176	25g	$146
ThiamineDisulfide	T344278	2.5g	$75
Thiaminedisulfide	J50009	25g	$120
THIAMINE DISULFIDE 95.00%	API0004386	25G	$210.11
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Thiamine disulfide Properties

Melting point	177° with intense yellow coloration
Boiling point	886.1±65.0 °C(Predicted)
Density	1.1966 (rough estimate)
refractive index	1.7400 (estimate)
storage temp.	Refrigerator
solubility	DMSO (Slightly), Methanol (Slightly)
pka	14.10±0.10(Predicted)
form	Solid
color	White
Merck	14,9297
Major Application	pharmaceutical small molecule
InChIKey	GFEGEDUIIYDMOX-YHARCJFQSA-N
SMILES	S(S\C(=C(\N(Cc2c(nc(nc2)C)N)C=O)/C)\CCO)\C(=C(\N(Cc1c(nc(nc1)C)N)C=O)/C)\CCO
CAS DataBase Reference	67-16-3(CAS DataBase Reference)
FDA UNII	UJV8K21YKL
EPA Substance Registry System	Formamide, N,N'-[dithiobis[2-(2-hydroxyethyl)-1-methyl-2,1-ethenediyl]]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]- (67-16-3)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
WGK Germany	WGK 3
RTECS	LQ2715000
TSCA	TSCA listed
HS Code	2936.22.0000
Storage Class	11 - Combustible Solids
Toxicity	LD50 intravenous in mouse: 500mg/kg

Thiamine disulfide price More Price(9)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR2216	Thiamine Disulfide Pharmaceutical Secondary Standard; Certified Reference Material	67-16-3	1 g	$639	2026-03-19	Buy
TCI Chemical	T0176	Thiamine Disulfide Hydrate >98.0%(T)	67-16-3	25g	$146	2026-03-19	Buy
TRC	T344278	ThiamineDisulfide	67-16-3	2.5g	$75	2021-12-16	Buy
AK Scientific	J50009	Thiaminedisulfide	67-16-3	25g	$120	2021-12-16	Buy
American Custom Chemicals Corporation	API0004386	THIAMINE DISULFIDE 95.00%	67-16-3	25G	$210.11	2021-12-16	Buy

Product number	Packaging	Price	Buy
PHR2216	1 g	$639	Buy
T0176	25g	$146	Buy
T344278	2.5g	$75	Buy
J50009	25g	$120	Buy
API0004386	25G	$210.11	Buy

Thiamine disulfide Chemical Properties,Uses,Production

Chemical Properties

White Solid

Originator

Arcalion,Servier,France,1974

Uses

Thiamine is a essential nutrient required for carbohydrate metabolism; also involved in nerve function. Biosynthesized by microorganisms and plants. Dietary sources include whole grains, meat products , vegetables, milk, legumes and fruit. Also present in rice husks and yeast. Converted in vivo to Thiamine diphosphate, a coenzyme in the decarboxylation of α-keto acids. Chronic deficiency may lead t o neurological impairment, bariberi, Wernicke-Korsakoff syndrome.

Uses

Thiamine disulfide is an antioxidant, inhibiting lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro. Thiamine disulfide has been explored as a potent inhibitor of HIV-1.

Definition

ChEBI: Thiamine disulfide is an aminopyrimidine, a homoallylic alcohol, a member of formamides and an organic disulfide.

Manufacturing Process

20 parts by weight of thiamin are dissolved in 25 parts of water, a cold solution of 5 parts by weight of caustic soda in 25 parts of water added and the mixture oxidized with a solution of 2.4 parts by weight of caustic soda and 20 parts by weight of potassium ferric cyanide in 80 parts of water while stirring in the cold. The liquid is then evaporated to dryness and the resulting oxidation product extracted with warm butyl alcohol.
The butyl-alcoholic solution is evaporated in vacuo and the residue dissolved with gentle heating in 25 parts by volume of methyl alcohol. 100 parts by volume of acetone are added, the solution filtered and further quantities of acetone added, whereupon crystallization sets in. Yield: 12.2 parts by weight of the pure product, having the melting point 177° to 179°C.

Therapeutic Function

Enzyme cofactor vitamin

Biological Activity

Thiamine Disulfide can be reduced by glutathione and thioredoxin (Trx) systems. In Caco-2 cells, thiamine disulfide derivatives did not alter the total thiol content, but it was significantly reduced by simultaneous inhibition of TrxR. When oxidative stress was induced by tert-butyl hydroperoxide, thiamine disulfide exerted a protective effect, indicating that the thiol form generated by disulfide reduction may be the active species. In addition, thiamine disulfide was shown to increase the nuclear levels of the transcription factor nuclear factor erythroid 2-related factor 2, and stimulate the expression and activity of NAD(P)H quinone dehydrogenase 1 and TrxR. However, other enzymes of the glutathione and Trx systems were barely affected^[1].

References

[1] FOLDA A, SCALCON V, TONOLO F, et al. Thiamine disulfide derivatives in thiol redox regulation: Role of thioredoxin and glutathione systems[J]. BioFactors, 2024, 3 1. DOI:10.1002/biof.2121.

Thiamine disulfide Preparation Products And Raw materials

Raw materials

Thiamine hydrochloride potassium ferricyanide

Preparation Products

Thiamine disulfide Suppliers

Global( 193)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21591	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29820	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569262 +86-15003564040	1056@dideu.com	China	3982	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8828	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32467	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15079	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
AFINE CHEMICALS LIMITED	58

View Lastest Price from Thiamine disulfide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-04-22	Thiamine disulfide 67-16-3	US $29.00 / mL		99.81%	10g	TargetMol Chemicals Inc.
	2019-07-06	Thiamine disulfide 67-16-3	US $1.00 / KG	1KG	98%	100kg	Career Henan Chemical Co

Thiamine disulfide
67-16-3
US $29.00 / mL
99.81%
TargetMol Chemicals Inc.

Thiamine disulfide
67-16-3
US $1.00 / KG
98%
Career Henan Chemical Co

Thiamine disulfide Spectrum

Thiamine disulfide(67-16-3)¹HNMR Thiamine disulfide(67-16-3)¹³CNMR Thiamine disulfide(67-16-3)IR1

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4-amino-2-methyl-5-pyrimidinyl)methyl]- formamide,n,n’-[dithiobis[2-(2-hydroxyethyl)-1-methyl-2,1-ethenediyl]]bis[n-[( ANEURINE DISULFIDE THIAMINE DISULFIDE BISTHIAMINE n,n'-(dithiobis(2-(2-hydroxyethyl)-1-methyl-2,1-ethenediyl))bis(n-((4-amino-2-methyl-5-pyrimidinyl)methyl)formamide TDS N,N'-[dithiobis[2-(2-hydroxyethyl)-1-methylvinylene]]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamide THIAMINE DISULFIDE(TDS) Vitamin B1 disulfide (Thiamine disulfide) Aneurin disulfide Daiomin Daisazin Neolamin N,N'-Dithiobis[4-hydroxy-1-methyl-1-butene-2,1-diyl]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamide] Algoneurina Einecs 200-644-4 N,N'-(Dithiobis(2-(2-hydroxyethyl)-1-methylvinylene))bis(N-((4-amino-2-methyl-5-pyrimidinyl)methyl)formamide) 2,1-ethenediyl))bis(N-((4-amino-2-methyl-5-pyrimidinyl)methyl)formamide Alitia S Apren S FeidMin 5 SSB1 ThiaMidin F ThiaMin Disulfide ThiaMine Disulfide Formamide, N,N-dithiobis2-(2-hydroxyethyl)-1-methyl-2,1-ethenediylbisN-(4-amino-2-methyl-5-pyrimidinyl)methyl- Thiamine Disulfide Hydrate N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-[(E)-3-[[(E)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-hydroxypent-2-en-3-yl]disulfanyl]-5-hydroxypent-2-en-2-yl]formamide Thiamine Impurity 12（Thiamine Disulfide） N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[(E)-3-[[(E)-2-[(4-amino-2-methyl-5-pyrimidinyl)methyl-formylamino]-5-hydroxypent-2-en-3-yl]disulfanyl]-5-hydroxypent-2-en-2-yl]formamide Thiamine Disulfide Hydrate> N,N'-(disulfanediylbis(5-hydroxypent-2-ene-3,2-diyl))bis(N-((4-amino-2-methylpyrimidin-5-yl)methyl)formamide) N-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-N-[3-[[2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-hydroxypent-2-en-3-yl]disulfanyl]-5-hydroxypent-2-en-2-yl]formamide Vitamin B1 Impurity 10 Thiamine disulfide, 10 mM in DMSO 67-16-3 C24H34N8O4S2 C24H34N8O4S2xH2O C24H34N8O4S2H2O Vitamins and derivatives Biochemistry Vitamin Derivatives Vitamins