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Thiamine disulfide

Thiamine disulfide structure

CAS No.: 67-16-3

Chemical Name:: Thiamine disulfide

Synonyms: TDS;SSB1;Daiomin;Apren S;Daisazin;Neolamin;Alitia S;FeidMin 5;BISTHIAMINE;Algoneurina

CBNumber:: CB9722783

Molecular Formula:: C24H34N8O4S2

Molecular Weight:: 562.71

MDL Number:: MFCD00010427

MOL File:: 67-16-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

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Thiamine disulfide Properties

Melting point	177° with intense yellow coloration
Boiling point	886.1±65.0 °C(Predicted)
Density	1.1966 (rough estimate)
refractive index	1.7400 (estimate)
storage temp.	Refrigerator
solubility	DMSO (Slightly), Methanol (Slightly)
pka	14.10±0.10(Predicted)
form	Solid
color	White
Merck	14,9297
Major Application	pharmaceutical small molecule
InChIKey	GFEGEDUIIYDMOX-YHARCJFQSA-N
SMILES	S(S\C(=C(\N(Cc2c(nc(nc2)C)N)C=O)/C)\CCO)\C(=C(\N(Cc1c(nc(nc1)C)N)C=O)/C)\CCO
CAS DataBase Reference	67-16-3(CAS DataBase Reference)
FDA UNII	UJV8K21YKL
EPA Substance Registry System	Formamide, N,N'-[dithiobis[2-(2-hydroxyethyl)-1-methyl-2,1-ethenediyl]]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]- (67-16-3)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338
WGK Germany	WGK 3
RTECS	LQ2715000
TSCA	TSCA listed
HS Code	2936.22.0000
Storage Class	11 - Combustible Solids
Toxicity	LD50 intravenous in mouse: 500mg/kg
REACH Registrations	Active

Thiamine disulfide price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR2216	Thiamine Disulfide Pharmaceutical Secondary Standard; Certified Reference Material	67-16-3	1 g	$639	2026-04-30	Buy
TCI Chemical	T0176	Thiamine Disulfide Hydrate >98.0%(T)	67-16-3	25g	$146	2026-04-30	Buy
Usbiological	263748	Bis[N-[(4-amino-2-methylpyrimidin-5-yl]methyl] Asreported	67-16-3	5g	$303	2026-06-03	Buy
Usbiological	263748	Bis[N-[(4-amino-2-methylpyrimidin-5-yl]methyl] Asreported	67-16-3	10g	$408	2026-06-03	Buy
Usbiological	263748	Bis[N-[(4-amino-2-methylpyrimidin-5-yl]methyl] Asreported	67-16-3	25g	$532	2026-06-03	Buy

Product number	Packaging	Price	Buy
PHR2216	1 g	$639	Buy
T0176	25g	$146	Buy
263748	5g	$303	Buy
263748	10g	$408	Buy
263748	25g	$532	Buy

Thiamine disulfide Chemical Properties, Uses, Production

Chemical Properties

White Solid

Originator

Arcalion,Servier,France,1974

Uses

Thiamine is a essential nutrient required for carbohydrate metabolism; also involved in nerve function. Biosynthesized by microorganisms and plants. Dietary sources include whole grains, meat products , vegetables, milk, legumes and fruit. Also present in rice husks and yeast. Converted in vivo to Thiamine diphosphate, a coenzyme in the decarboxylation of α-keto acids. Chronic deficiency may lead t o neurological impairment, bariberi, Wernicke-Korsakoff syndrome.

Uses

Thiamine disulfide is an antioxidant, inhibiting lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro. Thiamine disulfide has been explored as a potent inhibitor of HIV-1.

Definition

ChEBI: Thiamine disulfide is an aminopyrimidine, a homoallylic alcohol, a member of formamides and an organic disulfide.

Manufacturing Process

20 parts by weight of thiamin are dissolved in 25 parts of water, a cold solution of 5 parts by weight of caustic soda in 25 parts of water added and the mixture oxidized with a solution of 2.4 parts by weight of caustic soda and 20 parts by weight of potassium ferric cyanide in 80 parts of water while stirring in the cold. The liquid is then evaporated to dryness and the resulting oxidation product extracted with warm butyl alcohol.
The butyl-alcoholic solution is evaporated in vacuo and the residue dissolved with gentle heating in 25 parts by volume of methyl alcohol. 100 parts by volume of acetone are added, the solution filtered and further quantities of acetone added, whereupon crystallization sets in. Yield: 12.2 parts by weight of the pure product, having the melting point 177° to 179°C.

Therapeutic Function

Enzyme cofactor vitamin

Biological Activity

Thiamine Disulfide can be reduced by glutathione and thioredoxin (Trx) systems. In Caco-2 cells, thiamine disulfide derivatives did not alter the total thiol content, but it was significantly reduced by simultaneous inhibition of TrxR. When oxidative stress was induced by tert-butyl hydroperoxide, thiamine disulfide exerted a protective effect, indicating that the thiol form generated by disulfide reduction may be the active species. In addition, thiamine disulfide was shown to increase the nuclear levels of the transcription factor nuclear factor erythroid 2-related factor 2, and stimulate the expression and activity of NAD(P)H quinone dehydrogenase 1 and TrxR. However, other enzymes of the glutathione and Trx systems were barely affected^[1].

References

[1] FOLDA A, SCALCON V, TONOLO F, et al. Thiamine disulfide derivatives in thiol redox regulation: Role of thioredoxin and glutathione systems[J]. BioFactors, 2024, 3 1. DOI:10.1002/biof.2121.

Thiamine disulfide Preparation Products And Raw materials

Raw materials

Thiamine hydrochloride potassium ferricyanide

Preparation Products

Thiamine disulfide Suppliers

Global Suppliers ( 190)

Supplier	Tel	Email	Country	ProdList	Advantage
Lanzhou Dawnrays Pharmaceutical Co Ltd	0931-0931-4910898 19913936884	sales@dawnrays.com	China	39	58
Wuhan Tongyi Su Biotechnology Co., Ltd.	15071019375	634847344@qq.com	China	876	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Sichuan Kulinan Technology Co., Ltd	400-1166-196 18981987031	cdhxsj@163.com	China	11674	57
Maya High Purity Chemicals	+86 (573) 82222445 (0)18006601000 452520369	sales@maya-r.com	China	11693	57
Chengdu Ai Keda Chemical Technology Co., Ltd.	4008-755-333 18080918076	800078821@qq.com	China	9706	55
Beijing HuaMeiHuLiBiological Chemical	010-56205725	waley188@sohu.com	China	12323	58

Supplier	Advantage
Lanzhou Dawnrays Pharmaceutical Co Ltd	58
Wuhan Tongyi Su Biotechnology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Chemsky（shanghai）International Co.,Ltd.	50
Sichuan Kulinan Technology Co., Ltd	57
Maya High Purity Chemicals	57
Chengdu Ai Keda Chemical Technology Co., Ltd.	55
Beijing HuaMeiHuLiBiological Chemical	58

View Latest Price from Thiamine disulfide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	Thiamine disulfide 67-16-3	$29.00		99.81%	10g	TargetMol Chemicals Inc.
	2019-07-06	Thiamine disulfide 67-16-3	$1.00	1KG	98%	100kg	Career Henan Chemical Co

Thiamine disulfide
67-16-3
$29.00
99.81%
TargetMol Chemicals Inc.

Thiamine disulfide
67-16-3
$1.00
98%
Career Henan Chemical Co

Thiamine disulfide Spectrum

Thiamine disulfide(67-16-3)¹HNMR Thiamine disulfide(67-16-3)¹³CNMR Thiamine disulfide(67-16-3)IR1

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4-amino-2-methyl-5-pyrimidinyl)methyl]- formamide,n,n’-[dithiobis[2-(2-hydroxyethyl)-1-methyl-2,1-ethenediyl]]bis[n-[( ANEURINE DISULFIDE THIAMINE DISULFIDE BISTHIAMINE n,n'-(dithiobis(2-(2-hydroxyethyl)-1-methyl-2,1-ethenediyl))bis(n-((4-amino-2-methyl-5-pyrimidinyl)methyl)formamide N,N'-[dithiobis[2-(2-hydroxyethyl)-1-methylvinylene]]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamide THIAMINE DISULFIDE(TDS) Vitamin B1 disulfide (Thiamine disulfide) Aneurin disulfide Daiomin Daisazin Neolamin N,N'-Dithiobis[4-hydroxy-1-methyl-1-butene-2,1-diyl]bis[N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]formamide] Algoneurina Einecs 200-644-4 N,N'-(Dithiobis(2-(2-hydroxyethyl)-1-methylvinylene))bis(N-((4-amino-2-methyl-5-pyrimidinyl)methyl)formamide) 2,1-ethenediyl))bis(N-((4-amino-2-methyl-5-pyrimidinyl)methyl)formamide Alitia S Apren S FeidMin 5 SSB1 ThiaMidin F ThiaMin Disulfide ThiaMine Disulfide Formamide, N,N-dithiobis2-(2-hydroxyethyl)-1-methyl-2,1-ethenediylbisN-(4-amino-2-methyl-5-pyrimidinyl)methyl- Thiamine Disulfide Hydrate N-[(4-amino-2-methylpyrimidin-5-yl)methyl]-N-[(E)-3-[[(E)-2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-hydroxypent-2-en-3-yl]disulfanyl]-5-hydroxypent-2-en-2-yl]formamide Thiamine Impurity 12（Thiamine Disulfide） N-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-[(E)-3-[[(E)-2-[(4-amino-2-methyl-5-pyrimidinyl)methyl-formylamino]-5-hydroxypent-2-en-3-yl]disulfanyl]-5-hydroxypent-2-en-2-yl]formamide Thiamine Disulfide Hydrate> N,N'-(disulfanediylbis(5-hydroxypent-2-ene-3,2-diyl))bis(N-((4-amino-2-methylpyrimidin-5-yl)methyl)formamide) N-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-N-[3-[[2-[(4-amino-2-methylpyrimidin-5-yl)methyl-formylamino]-5-hydroxypent-2-en-3-yl]disulfanyl]-5-hydroxypent-2-en-2-yl]formamide Vitamin B1 Impurity 10 Thiamine disulfide, 10 mM in DMSO TDS 67-16-3 C24H34N8O4S2 C24H34N8O4S2xH2O C24H34N8O4S2H2O Vitamins and derivatives Biochemistry Vitamin Derivatives Vitamins