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GRA Ex-25

GRA Ex-25 Structure
GRA Ex-25 structure
CAS No.
307983-31-9
Chemical Name:
GRA Ex-25
Synonyms
GRA Ex-25;GRA Ex-25[GRA-Ex-25;GRA Ex-25 USP/EP/BP;GRA Ex-25, 10 mM in DMSO;GCGR,inhibit,GRA Ex 25,Inhibitor,GRA Ex-25,Glucagon Receptor,GRA Ex25;3-(4-((1-(trans-4-(tert-Butyl)cyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)propanoic acid;β-Alanine, N-[4-[[[trans-4-(1,1-dimethylethyl)cyclohexyl][[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]methyl]benzoyl]-;3-{[4-({1-[(1r,4r)-4-tert-butylcyclohexyl]{[4-(trifluoromethoxy)phenyl]carbamoyl}amino}methyl)phenyl]formamido}propanoic acid;B-Alanine, N-[4-[[[trans-4-(1,1-dimethylethyl)cyclohexyl][[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]methyl]benzoyl]-
CBNumber:
CB11872296
Molecular Formula:
C29H36F3N3O5
Molecular Weight:
563.61
MDL Number:
MFCD11977277
MOL File:
307983-31-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:17:05
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GRA Ex-25 Properties

Melting point 152-154 °C
Boiling point 726.3±60.0 °C(Predicted)
Density 1.28±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMF:25.0(Max Conc. mg/mL);44.36(Max Conc. mM)
DMSO:28.5(Max Conc. mg/mL);50.57(Max Conc. mM)
DMF:PBS (pH 7.2) (1:8):0.1(Max Conc. mg/mL);0.18(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);17.74(Max Conc. mM)
form A crystalline solid
pka 4.29±0.10(Predicted)
color White to off-white
InChIKey BZXMLCVDKDXRQY-AFARHQOCNA-N
SMILES C(C)(C)([C@@H]1CC[C@H](CC1)N(CC1=CC=C(C=C1)C(=O)NCCC(=O)O)C(=O)NC1=CC=C(C=C1)OC(F)(F)F)C |&1:3,6,r|

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

GRA Ex-25 price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 29727 GRA Ex-25 ≥98% 307983-31-9 1mg $36 2026-04-30 Buy
Cayman Chemical 29727 GRA Ex-25 ≥98% 307983-31-9 5mg $153 2026-04-30 Buy
Cayman Chemical 29727 GRA Ex-25 ≥98% 307983-31-9 10mg $268 2026-04-30 Buy
Cayman Chemical 29727 GRA Ex-25 ≥98% 307983-31-9 25mg $587 2026-04-30 Buy
ChemScene CS-6006 GRA Ex-25 99.07% 307983-31-9 5mg $151 2026-06-04 Buy
Product number Packaging Price Buy
29727 1mg $36 Buy
29727 5mg $153 Buy
29727 10mg $268 Buy
29727 25mg $587 Buy
CS-6006 5mg $151 Buy

GRA Ex-25 Chemical Properties, Uses, Production

Uses

GRA Ex-25 is an inhibitor of glucagon receptor, with IC50 of 56 and 55 nM for rat and human glucagon receptors, respectively.

in vivo

GRA Ex-25 (3 mg/kg, i.v.) significantly reduces blood glucose caused by exogenous administration of glucagon in rat model. GRA Ex-25 is able to inhibit the rise in blood glucose levels elicited by exogenous administered glucagon, most likely because of the direct inhibition of glucagon stimulated hepatic glucose output[2].

References

[1] Kurukulasuriya R, et al. Biaryl amide glucagon receptor antagonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2047-50. DOI:10.1016/j.bmcl.2004.02.056
[2] Kurukulasuriya R, et al. Biaryl amide glucagon receptor antagonists. Bioorg Med Chem Lett. 2004 May 3;14(9):2047-50. DOI:10.1021/jm058026u

GRA Ex-25 Preparation Products And Raw materials

Raw materials

Preparation Products

GRA Ex-25 Suppliers

Global Suppliers ( 65)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4853 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9711 58
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Musechem +1-800-259-7612 info@musechem.com United States 4648 60
Shanghai BetterBioChem Co., Ltd. +86-18017644823 sales@betterbiochem.com China 324 58
Twochem Co.Ltd. 021-58111628 15800915896 sales@twochem.com China 1782 58
Supplier Advantage
BOC Sciences 65
MedChemexpress LLC 58
Bide Pharmatech Ltd. 60
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Chaolan Chemical Technology Center 58
Amadis Chemical Company Limited 58
Musechem 60
Shanghai BetterBioChem Co., Ltd. 58
Twochem Co.Ltd. 58

GRA Ex-25 Spectrum

GRA Ex-25(307983-31-9)1HNMR

307983-31-9 (GRA Ex-25) Related Search:

GRA Ex-25 β-Alanine, N-[4-[[[4-(1,1-dimethylethyl)phenyl][[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]methyl]benzoyl]- 2-((4R)-4-((3R,5R,6S,7R,10R,13R)-3,6,7-Trihydroxy-10,13-Dimethylhexadecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl)Pentanamido)Acetic Acid 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide Tauro-β-muricholic Acid-d4 Sodium Salt
ex229 (compound 991)

1of2

GRA Ex-25 B-Alanine, N-[4-[[[trans-4-(1,1-dimethylethyl)cyclohexyl][[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]methyl]benzoyl]- β-Alanine, N-[4-[[[trans-4-(1,1-dimethylethyl)cyclohexyl][[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]methyl]benzoyl]- GRA Ex-25 USP/EP/BP GRA Ex-25[GRA-Ex-25 GCGR,inhibit,GRA Ex 25,Inhibitor,GRA Ex-25,Glucagon Receptor,GRA Ex25 3-(4-((1-(trans-4-(tert-Butyl)cyclohexyl)-3-(4-(trifluoromethoxy)phenyl)ureido)methyl)benzamido)propanoic acid 3-{[4-({1-[(1r,4r)-4-tert-butylcyclohexyl]{[4-(trifluoromethoxy)phenyl]carbamoyl}amino}methyl)phenyl]formamido}propanoic acid GRA Ex-25, 10 mM in DMSO 307983-31-9 C29H36F3N3O5