5,6-Dichloro-1H-benzimidazol-2-amine
- CAS No.
- 18672-03-2
- Chemical Name:
- 5,6-Dichloro-1H-benzimidazol-2-amine
- Synonyms
- 5,6-DICHLORO-1H-BENZO[D]IMIDAZOL-2-AMINE;2-Amino-5,6-dichlorobenzimidazole;5,6-Dichloro-1H-benzimidazol-2-amine;2-Amino-5,6-dichloro-1H-benzimidazole;1H-Benzimidazol-2-amine, 5,6-dichloro-;5,6-dichloro-1H-1,3-benzodiazol-2-amine
- CBNumber:
- CB1206007
- Molecular Formula:
- C7H5Cl2N3
- Molecular Weight:
- 202.04
- MDL Number:
- MFCD08234602
- MOL File:
- 18672-03-2.mol
- MSDS File:
- SDS
| Melting point | 244-246℃ |
|---|---|
| Boiling point | 435.4±48.0 °C(Predicted) |
| Density | 1.665±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| pka | 8.47±0.10(Predicted) |
| Appearance | Light yellow to light brown Solid |
| CAS DataBase Reference | 18672-03-2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P301+P310a-P305+P351+P338-P405-P501a | |||||||||
| NFPA 704 |
|
5,6-Dichloro-1H-benzimidazol-2-amine price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS113300 | 5,6-Dichloro-1H-benzo[d]imidazol-2-amine 96% | 18672-03-2 | 1g | $124 | 2026-06-04 | Buy |
| Activate Scientific | AS113300 | 5,6-Dichloro-1H-benzo[d]imidazol-2-amine 96% | 18672-03-2 | 5g | $521 | 2026-06-04 | Buy |
| Activate Scientific | AS113300 | 5,6-Dichloro-1H-benzo[d]imidazol-2-amine 96% | 18672-03-2 | 25g | $1636 | 2026-06-04 | Buy |
| Matrix Scientific | 294940 | 5,6-Dichloro-1H-benzo[d]imidazol-2-amine | 18672-03-2 | 250.00mg | $41 | 2026-05-19 | Buy |
| Matrix Scientific | 294940 | 5,6-Dichloro-1H-benzo[d]imidazol-2-amine | 18672-03-2 | 1.00g | $82 | 2026-05-19 | Buy |
5,6-Dichloro-1H-benzimidazol-2-amine Chemical Properties, Uses, Production
Uses
2-Amino-5,6-dichlorobenzimidazole is used as pharmaceutical intermediate.
Synthesis
5348-42-5
506-68-3
18672-03-2
Example 138: General procedure for the synthesis of 5,6-dichloro-1H-benzo[d]imidazol-2-amine from 4,5-dichloro-1,2-benzenediamine and cyanogen bromide: Cyanogen bromide (0.063 g, 0.6 mmol) was added to a mixture of acetonitrile (10 mL) and water (0.81 g, 0.562 mmol) of 4,5-dichlorobenzene-1,2-diamine (0.81 g, 0.562 mmol) at 0 °C. (2 mL) in a mixed solution of acetonitrile (10 mL) and water (2 mL). The reaction mixture was gradually warmed to room temperature with continuous stirring for 14 hours. Subsequently, saturated aqueous sodium bicarbonate solution (50 mL) was added to the reaction mixture and shaken thoroughly. The resulting solid was collected by filtration, washed with water and dried under reduced pressure to afford 5,6-dichloro-1H-benzo[d]imidazol-2-amine 0.43 g in 50% yield. Mass spectrometry (EI) analysis showed a molecular ion peak (MH+) of 203.
References
[1] Journal of Medicinal Chemistry, 1995, vol. 38, # 20, p. 4098 - 4105
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 8, p. 1252 - 1262
[3] Bioorganic and medicinal chemistry letters, 2002, vol. 12, # 16, p. 2221 - 2224
[4] Patent: WO2008/42282, 2008, A2. Location in patent: Page/Page column 208
[5] Angewandte Chemie - International Edition, 2012, vol. 51, # 41, p. 10364 - 10367
5,6-Dichloro-1H-benzimidazol-2-amine Preparation Products And Raw materials
5,6-Dichloro-1H-benzimidazol-2-amine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Chiba Pharmaceutical Science and technology Co, Ltd. | 0531-81313138 13066006660 | chibapharm@foxmail.com | China | 3996 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Shanghai Keepontech Co.,Ltd | 021-54849683 13601642561 | sales@keepontech.com | China | 998 | 59 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Wuhan Chemwish Technology Co.， Ltd | 027-67849912 | sales@chemwish.com | China | 9144 | 60 |
| Yancheng KangdiSen Pharmaceutical Co., Ltd. | 13812573443;18052965989 | tongbenwan22@163.com | China | 1975 | 55 |
View Latest Price from 5,6-Dichloro-1H-benzimidazol-2-amine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE
18672-03-2
|
$90.00-900.00 | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd |
-
- 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE
18672-03-2
- $90.00-900.00
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
