5,6-Dichlorobenzimidazole
- CAS No.
- 6478-73-5
- Chemical Name:
- 5,6-Dichlorobenzimidazole
- Synonyms
- NSC 6393;NSC 63938;NSC 326397;BUTTPARK 121\15-71;Astemizole Impurity 5;5, 6-dichlorobenidazole;5,6-Dichlorobenzimidazole;5,6-DICHLORO-1H-BENZIMIDAZOLE;1H-BENZIMIDAZOLE, 5,6-DICHLORO-;5,6-DICHLORO-1H-BENZO[D]IMIDAZOLE
- CBNumber:
- CB7168794
- Molecular Formula:
- C7H4Cl2N2
- Molecular Weight:
- 187.03
- MDL Number:
- MFCD00211325
- MOL File:
- 6478-73-5.mol
- MSDS File:
- SDS
| Melting point | 205-206° |
|---|---|
| Boiling point | 426.9±25.0 °C(Predicted) |
| Density | 1.571±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 10.74±0.30(Predicted) |
| color | Tan to Light Beige |
| CAS DataBase Reference | 6478-73-5(CAS DataBase Reference) |
| FDA UNII | 62J7FY37SD |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933998090 | |||||||||
| NFPA 704 |
|
5,6-Dichlorobenzimidazole price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D5146 | 5,6-Dichlorobenzimidazole >98.0%(GC)(T) | 6478-73-5 | 1g | $91 | 2026-04-30 | Buy |
| TCI Chemical | D5146 | 5,6-Dichlorobenzimidazole >98.0%(GC)(T) | 6478-73-5 | 5g | $311 | 2026-04-30 | Buy |
| TRC | TRC-D431900-500MG | 5,6-Dichlorobenzimidazole | 6478-73-5 | 500mg | $135 | 2026-06-03 | Buy |
| TRC | TRC-D431900-250MG | 5,6-Dichlorobenzimidazole | 6478-73-5 | 250mg | $78 | 2026-06-03 | Buy |
| TRC | TRC-D431900-1G | 5,6-Dichlorobenzimidazole | 6478-73-5 | 1g | $237 | 2026-06-03 | Buy |
5,6-Dichlorobenzimidazole Chemical Properties, Uses, Production
Chemical Properties
Purple Solid
Uses
A benzimidazole derivative as potent inhibitor of milk xanthine oxidase.
Synthesis
6478-78-0
6478-73-5
General procedure for the synthesis of 5,6-dichlorobenzimidazole from N-benzylbenzimidazole (CAS:6478-78-0, 208.1 mg, 1.0 mmol): to a 16 mL reaction flask equipped with a PTFE/silicone septum and a nitrogen bubbling device under nitrogen protection were added N-benzylbenzimidazole, a dry Pd/C catalyst (10 wt%. 20 mg) and THF (5 mL). Subsequently, triethylsilane (320 μL, 2.0 mmol) was slowly added to the reaction mixture at room temperature and stirred continuously for 14 h under nitrogen atmosphere. Upon completion of the reaction, the reaction mixture was filtered through a 0.45 μm PTFE syringe filter to remove the catalyst and the filtrate was concentrated under reduced pressure to remove the solvent. The residue was purified by column chromatography (eluent: 0 to 10% MeOH/dichloromethane gradient) to afford the target product 5,6-dichlorobenzimidazole as a colorless solid (117.6 mg, 0.996 mmol, 99% yield). It is worth noting that an induction period of 5 to 30 min usually exists at the beginning of the reaction, which is manifested by the beginning of gas release from the reaction mixture (i.e., the bubbling phenomenon). In addition, the use of a dry Pd/C catalyst is critical to the success of the reaction; wet Pd/C may result in a significant decrease in the reaction yield or no reaction at all.
References
[1] Tetrahedron Letters, 2015, vol. 56, # 21, p. 2688 - 2690
5,6-Dichlorobenzimidazole Preparation Products And Raw materials
Raw materials
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Preparation Products
5,6-Dichlorobenzimidazole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Hangzhou Dingxin Biotechnology Co., Ltd. | 0571-88194596 15558156576 | sales@disynchem.com | China | 94 | 55 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
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