O-Phenylhydroxylamine hydrochloride
- CAS No.
- 6092-80-4
- Chemical Name:
- O-Phenylhydroxylamine hydrochloride
- Synonyms
- O-phenylhydroxylamine;o-PhenylhydroxylamineHCl;PHENOXYAMINE HYDROCHLORIDE;O-Phenylhydroxyamine hydrochloride;O-Phenylhydroxylamine hydrochloride;(Aminooxy)benzene hydrochloride (1:1);HydroxylaMine, O-phenyl-, hydrochloride;O-Phenylhydroxylamine hydrochloride, 97%,;O-Phenylhydroxylamine hydrochloride;Hydroxylamine, O-phenyl-, hydrochloride (1:1)
- CBNumber:
- CB1208829
- Molecular Formula:
- C6H8ClNO
- Molecular Weight:
- 145.59
- MDL Number:
- MFCD00043271
- MOL File:
- 6092-80-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | ~132 °C (dec.) |
|---|---|
| storage temp. | 2-8°C |
| form | Powder |
| color | White to yellow |
| BRN | 4326059 |
| InChI | InChI=1S/C6H7NO.ClH/c7-8-6-4-2-1-3-5-6;/h1-5H,7H2;1H |
| InChIKey | DBTXKJJSFWZJNS-UHFFFAOYSA-N |
| SMILES | C1(ON)C=CC=CC=1.Cl |
| CAS DataBase Reference | 6092-80-4 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301+P310 |
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
| Hazard Codes | F,T |
| Risk Statements | 11-25 |
| Safety Statements | 16-22-24/25-45 |
| RIDADR | UN2811 6.1/PG 3 |
| WGK Germany | 3 |
| F | 4.6-10-21 |
| HS Code | 2928009090 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral |
O-Phenylhydroxylamine hydrochloride price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 78725 | O-Phenylhydroxylamine hydrochloride 97% | 6092-80-4 | 1g | $209 | 2026-04-30 | Buy |
| TCI Chemical | P3245 | O-Phenylhydroxylamine Hydrochloride | 6092-80-4 | 200MG | $60 | 2026-04-30 | Buy |
| TCI Chemical | P3245 | O-Phenylhydroxylamine Hydrochloride | 6092-80-4 | 1G | $180 | 2026-04-30 | Buy |
| Apolloscientific | OR940013 | O-Phenylhydroxylamine hydrochloride 97% | 6092-80-4 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR940013 | O-Phenylhydroxylamine hydrochloride 97% | 6092-80-4 | 1g | $33 | 2026-06-04 | Buy |
O-Phenylhydroxylamine hydrochloride Chemical Properties, Uses, Production
Uses
O-phenylhydroxylamine hydrochloride is mainly used in organic synthesis and experimental research.
Hazard
O-phenylhydroxylamine hydrochloride causes skin irritation and serious eye irritation and has acute oral toxicity, it is toxic if swallowed.
Synthesis
4846-21-3
6092-80-4
General procedure for the synthesis of O-phenylhydroxylamine hydrochloride from compound (CAS: 4846-21-3): a representative method for the preparation of the corresponding O-arylhydroxylamine by hydrazinolysis of N-aryloxyphthalimide (Method 1A): synthesis of compound 1; hydrazine monohydrate (0.401 mL, 8.2 mmol) was slowly added to N-phenoxyphthalimide 9 ( 652 mg, 2.73 mmol) dissolved in a 10% MeOH solution of CHCl3 (25 mL) and the reaction was stirred at room temperature. Upon completion of the reaction (monitored by TLC, 12 h), a white precipitate (phthalazine) appeared in the colorless reaction solution. The reaction mixture was filtered through a silica gel plug and washed with a hexane solution of 30% EtOAc. Removal of EtOAc/hexane gave a light yellow oil, which was distilled by Kugelrohr to give pure phenoxyamine 1 as a clear, colorless oil (238 mg, 80% yield) from K2CO3 (<10 mg); the characterization data are given below. Alternatively, after removal of EtOAc/hexane, the yellow oily substance was dissolved in Et2O and cooled to 0 °C. After being kept at 0 °C for 10 min, a solution of 4N HCl in dioxane was added dropwise until the pH reached 3. The resulting white solid was filtered and washed with Et2O (2 × 10 mL) to give the pure HCl salt (306 mg, 77% yield) of 1. O-Phenylhydroxylamine hydrochloride (1) was prepared as described above as a representative procedure (Method 1A). 1H-NMR (400 MHz , CD3OD) δ 6.84-6.89 (m, 1H), 7.03-7.09 (m, 2H), 7.19-7.25 (m, 2H); 13C-NMR (100 MHz, CD3OD) δ 114.1, 121.6, 130.3, 163.1; LC-MS m/z 110 [MH]+, theoretical value for C6H8NO 110.
References
[1] Patent: US2006/178527, 2006, A1. Location in patent: Page/Page column 8; sheet 6
[2] Synlett, 2009, # 18, p. 3003 - 3006
O-Phenylhydroxylamine hydrochloride Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Kangrui Pharmaceutical Technology Co., Ltd. | +86-0519-85485169 +86-13961161173 | sales@kangruipharm.com | China | 285 | 58 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Zhengzhou Kingsfine Chemical Co., Ltd. | 0371-56635027 13838252817 | sales@kingsfine.com | China | 100 | 62 |
| Beijing Taiya Jie Technology Development Co., Ltd. | 021-33690831-8001 13552411790;18616022633 | postmaster@tyjchem.cn | China | 1541 | 55 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3980 | 55 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 |
View Latest Price from O-Phenylhydroxylamine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | O-PHENYLHYDROXYLAMINE HYDROCHLORIDE
6092-80-4
|
$1.00-4.00 | 1KG | 99% | 200000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2026-08-07 | O-Phenylhydroxylamine hydrochloride
6092-80-4
|
$1.35-568.00 | 1Kg | 99% | 100000 | Shaanxi Dideu Medichem Co. Ltd | |
 |
2026-06-30 | O-PHENYLHYDROXYLAMINE HYDROCHLORIDE
6092-80-4
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- O-PHENYLHYDROXYLAMINE HYDROCHLORIDE
6092-80-4
- $1.00-4.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- O-Phenylhydroxylamine hydrochloride
6092-80-4
- $1.35-568.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- O-PHENYLHYDROXYLAMINE HYDROCHLORIDE
6092-80-4
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
