(2-amino-3-hydroxy-octadecoxy)phosphonic acid
- CAS No.
- 19794-97-9
- Chemical Name:
- (2-amino-3-hydroxy-octadecoxy)phosphonic acid
- Synonyms
- 2S-amino-1;SPHINGANINE-1-PHOSPHATE;dihydrosphingosine 1-phosphate;(2S,3R)-Sphinganine 1-Phosphate;Sphinganine-1-phosphate (d18:0);D-erythro-sphinganine-1-phosphate;C18-Dihydrosphingosine 1-Phosphate;(2-amino-3-hydroxy-octadecoxy)phosphonic acid;
D -erythro-Dihydrosphingosine 1-phosphate;(2S,3R)-2-AMino-1,3-octadecanediol 1-(Dihydrogen Phosphate)
- CBNumber:
- CB12129494
- Molecular Formula:
- C18H40NO5P
- Molecular Weight:
- 381.49
- MDL Number:
- MOL File:
- 19794-97-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| D3439 | 1mg | $302 | |
| Sphinganine-1-phosphate (d18:0) ≥95% | 22500 | 500μg | $69 |
| Sphinganine-1-phosphate (d18:0) ≥95% | 22500 | 1mg | $120 |
| Sphinganine-1-phosphate (d18:0) ≥95% | 22500 | 5mg | $461 |
| D-erythro-Dihydro-D-sphingosine-1-phosphate | D3577-51 | 5mg | $562 |
| More product size | |||
| Boiling point | 548.2±60.0 °C(Predicted) |
|---|---|
| Density | 1.080±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | 0.3 M NaOH: 4 mg/ml; DMF: <50 μg/ml; DMSO: <50 μg/ml; Ethanol: <50 μg/ml; PBS (pH 7.2): <50 μg/ml |
| form | A crystalline solid |
| pka | 1.76±0.10(Predicted) |
| color | White to off-white |
| InChI | 1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/t17-,18+/m0/s1 |
| InChIKey | YHEDRJPUIRMZMP-ZWKOTPCHSA-N |
| SMILES | CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)COP(O)(O)=O |
| UNSPSC Code | 12352211 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
(2-amino-3-hydroxy-octadecoxy)phosphonic acid price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D3439 | 19794-97-9 | 1mg | $302 | 2026-04-30 | Buy | |
| Cayman Chemical | 22500 | Sphinganine-1-phosphate (d18:0) ≥95% | 19794-97-9 | 500μg | $69 | 2026-04-30 | Buy |
| Cayman Chemical | 22500 | Sphinganine-1-phosphate (d18:0) ≥95% | 19794-97-9 | 1mg | $120 | 2026-04-30 | Buy |
| Cayman Chemical | 22500 | Sphinganine-1-phosphate (d18:0) ≥95% | 19794-97-9 | 5mg | $461 | 2026-04-30 | Buy |
| Usbiological | D3577-51 | D-erythro-Dihydro-D-sphingosine-1-phosphate | 19794-97-9 | 5mg | $562 | 2026-06-03 | Buy |
(2-amino-3-hydroxy-octadecoxy)phosphonic acid Chemical Properties,Uses,Production
Chemical Properties
White to Beige Solid
Uses
(2-amino-3-hydroxy-octadecoxy)phosphonic acid may be used as a negative control for C2 Ceramide.
Definition
ChEBI: A sphingoid 1-phosphate that is the monophosphorylated derivative of sphinganine.
Biochem/physiol Actions
Negative control for sphingosine-1-phosphate.
in vivo
Sphinganine 1-phosphate can enhance wound healing in diabetic mice[1]. Sphinganine 1-phosphate provides renal and hepatic protection after liver ischemia and reperfusion (IR) injury in mice through selective activation of S1P1 receptors and pertussis toxin-sensitive G-proteins with subsequent activation of ERK and Akt. Sphinganine 1-phosphate (administered 0.1 mg/kg i.v. immediately before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion) protects against hepatic and renal injury after liver IR[2].
| Animal Model: | Male C57BL/6 mice (20-25g)[2] |
| Dosage: | 0.1mg/kg |
| Administration: | Administered i.v. immediately before reperfusion and 0.2mg/kg s.c. 2 h after reperfusion |
| Result: | The plasma level of alanine aminotransferase (ALT) and Creatinine (Cr) was 80±6 U/L and 0.46±0.05 mg/dL, respectively. The increases in ALT (7474±557U/L) and Cr (0.55±0.05mg/dL) were significantly suppressed at 24h after reperfusion in mice treated with 0.1mg/kg i.v. before reperfusion and 0.2mg/kg s.c. 2h after reperfusion. |
IC 50
Human Endogenous Metabolite
(2-amino-3-hydroxy-octadecoxy)phosphonic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Yichang Zhongyitai Trading Co., Ltd. | 0717-6449896 13886658719 | root@zhongyitai.com | China | 1978 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Codow Chemical Co.,Ltd. | -- | amy@howeipharm.com | China | 6669 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89667 | 60 |
| Shanghai Uteam Biotechnology Co., Ltd. | 021-36031160 13311776681 | 3338195766@QQ.com | China | 5091 | 55 |
| Shanghai Biological Technology Development Co., Ltd. | 021-69955236-807 13918189704 | chinaruji@chinaruji.com | China | 5093 | 55 |
