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(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone

(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone structure

CAS No.: 131685-53-5

Chemical Name:: (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone

Synonyms: (R)-3-(1-Oxopropyl)-4-b;R-4-Benzyl-3-Propiony-2-Oxazolidinone;N-PROPIONYL-(4R)-BENZYL-2-OXAZOLIDINONE;(R)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE;(-)-4-Benzyl-3-propionyl-2-oxazolidinone;(R)-4-benzy1-3-propionyloxazolidin-2-one;(4R)-4-Benzyl-3-propionyloxazolidin-2-one;N-3-PROPIONYL-(4R)-BENZYL-2-OXAZOLIDINONE;(4R)-4-benzyl-3-propanoyl-1,3-oxazolidin-2;(R)-(-)-4-Benzyl-3-propiomyl-2-oxazolidinone

CBNumber:: CB1217072

Molecular Formula:: C13H15NO3

Molecular Weight:: 233.26

MDL Number:: MFCD00269687

MOL File:: 131685-53-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:49:01

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(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone Properties

Melting point	45 °C
Boiling point	396.6±11.0 °C(Predicted)
Density	1.206±0.06 g/cm3(Predicted)
refractive index	-103 ° (C=1, EtOH)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform, Ethanol
pka	-2.35±0.40(Predicted)
form	Solid
color	Off-White
optical activity	[α]20/D 102°, c = 1 in ethanol
InChI	InChI=1S/C13H15NO3/c1-2-12(15)14-11(9-17-13(14)16)8-10-6-4-3-5-7-10/h3-7,11H,2,8-9H2,1H3/t11-/m1/s1
InChIKey	WHOBYFHKONUTMW-LLVKDONJSA-N
SMILES	O1C[C@@H](CC2=CC=CC=C2)N(C(=O)CC)C1=O
CAS DataBase Reference	131685-53-5(CAS DataBase Reference)
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Hazard Codes	Xi,Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	26-36-24/25
WGK Germany	3
HS Code	29349990
Storage Class	11 - Combustible Solids

(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone price More Price(75)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	459542	(R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone 99%	131685-53-5	1g	$54.2	2023-01-07	Buy
Sigma-Aldrich	459542	(R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone 99%	131685-53-5	5g	$224	2023-01-07	Buy
TCI Chemical	B2165	(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone >98.0%(GC)	131685-53-5	1g	$43	2026-04-30	Buy
TCI Chemical	B2165	(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone >98.0%(GC)	131685-53-5	5g	$138	2026-04-30	Buy
Usbiological	241587	(R)-4-Benzyl-3-propionyl-2-oxazolidinone 99+% (HPLC) ≥99%(HPLC)	131685-53-5	1g	$325	2026-06-03	Buy

Product number	Packaging	Price	Buy
459542	1g	$54.2	Buy
459542	5g	$224	Buy
B2165	1g	$43	Buy
B2165	5g	$138	Buy
241587	1g	$325	Buy

(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE is a oxazolidinone derivative used in the preparation of anisomycin analogues as activators of the JNK/SAPK1 and p38/SAPK2 pathways.

Uses

(R)-()-4-Benzyl-3-propionyl-2-oxazolidinone can be used as a building block for the preparation of methyl 3-[(S)-3-((R)-4-benzyl-2-oxooxazolidin-3-yl)-2-methyl-3-oxopropyl]benzoate by treating with strong base followed by the addition of methyl 3-bromomethyl benzoate.

General Description

(R)-()-4-Benzyl-3-propionyl-2-oxazolidinone is used as a building block in organic synthesis for the preparation of oxazolidinone derivatives.

Synthesis

90719-32-7

79-03-8

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE

131685-53-5

Under nitrogen protection, (S)-4-benzyl-2-azolidinone (800 mg, 4.5 mmol) was dissolved in a dry reaction vial of anhydrous tetrahydrofuran (30 mL) and cooled to -78 °C in a dry ice/acetone bath. A hexane solution of 1.6 M n-butyllithium (5.0 mmol, 3.1 mL) was added slowly and dropwise over 3 min. After stirring for 30 min, propionyl chloride (5.0 mmol, 0.43 mL) was added slowly over 3 min. The reaction solution was slowly warmed to room temperature over 14 h. The reaction was subsequently quenched by the addition of saturated ammonium chloride solution (10 mL) and water (30 mL). The aqueous layer was extracted with ethyl acetate (3 x 40 mL), the organic phases were combined and dried over anhydrous magnesium sulfate. The organic phase was concentrated under reduced pressure to afford (R)-(-)-benzyl-3-propionyl-2-oxazolidinone (oil, 1.0 g, 96% yield) with >95% purity by HPLC.1H NMR (500 MHz, CDCl3): δ 7.33 (dd, J1 = 7.4 Hz, J2 = 7.6 Hz, 2H), 7.29 (d, J = 6.9 Hz, 1H) ), 7.21 (d, J = 7.4 Hz, 2H), 4.67 (m, 1H), 4.18 (m, 2H), 3.31 (dd, J1 = 13.3 Hz, J2 = 3.2 Hz, 1H), 2.96 (m, 2H), 2.77 (dd, J1 = 13.3 Hz, J2 = 3.7 Hz, 1H), 1.21 (t, J = 7.4 Hz, 1H). 3H).

References

[1] Chemistry - An Asian Journal, 2011, vol. 6, # 7, p. 1791 - 1799
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 144 - 148
[3] Journal of Organic Chemistry, 2008, vol. 73, # 8, p. 3292 - 3294
[4] Angewandte Chemie - International Edition, 2016, vol. 55, # 13, p. 4252 - 4255
[5] Angew. Chem., 2016, vol. 128, # 13, p. 4324 - 4327,4

(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone Preparation Products And Raw materials

Raw materials

(S)-4-Benzyl-2-oxazolidinone Propionic anhydride Propionyl chloride Tetrahydrofuran n-Butyllithium

Hexane

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Preparation Products

(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone Suppliers

Global( 215)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Leto Pharmatech Co.,Ltd.	86-021-5821 5861; 18016401466	sales@letopharm.com	China	235	58
Shang Hai Muse Health Tech Co., Ltd.	02161069951 13262285760	xul@musehealthtech.com	China	187	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Longsheng chemical Co.,Ltd.	58099637 13585536065	sales@shlschem.com	China	9880	59

Supplier	Advantage
Shanghai Leto Pharmatech Co.,Ltd.	58
Shang Hai Muse Health Tech Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Capot Chemical Co., Ltd	66
Jia Xing Isenchem Co.,Ltd	66
Accela ChemBio Co.,Ltd.	64
Shanghai Longsheng chemical Co.,Ltd.	59

View Lastest Price from (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-04	(R)-4-benzy1-3-propionyloxazolidin-2-one 131685-53-5		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2021-08-12	(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE 131685-53-5	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06	(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE 131685-53-5	$1.00	1KG	99%	200kg	Career Henan Chemical Co

(R)-4-benzy1-3-propionyloxazolidin-2-one
131685-53-5
98%
Henan Aochuang Chemical Co.,Ltd.

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE
131685-53-5
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE
131685-53-5
$1.00
99%
Career Henan Chemical Co

(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone Spectrum

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE(131685-53-5)¹HNMR (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE(131685-53-5)IR

131685-53-5((R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone)Related Search:

3-[(4-Methoxyphenyl)acetyl]-(4R)-(phenylmethyl)-2-oxazolidinone (R)-4-Benzyl-3-(3-cyclopentyl-propionyl)-oxazolidin-2-one (R)-4-Benzyl-3-(3-cyclopropyl-propionyl)-oxazolidin-2-one 3-(2-Phenylacetyl)-(4R)-(phenylmethyl)-2-oxazolidinone (R)-4-Benzyl-3-(4-methyl-pentanoyl)-oxazolidin-2-one

(3S,4R)-4-Benzyl-3-(3-methylpentanoyl)-oxazolidin-2-one (4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE 3-(4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-hexanoic acid tert-butyl ester (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one

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(R)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE N-PROPIONYL-(4R)-BENZYL-2-OXAZOLIDINONE N-3-PROPIONYL-(4R)-BENZYL-2-OXAZOLIDINONE (R)-(-)-4-Benzyl-3-propiomyl-2-oxazolidinone (4R)-4-benzyl-3-propanoyl-1,3-oxazolidin-2-one (-)-4-Benzyl-3-propionyl-2-oxazolidinone (4R)-4-Benzyl-3-propionyl-1,3-oxazolidin-2-one (4R)-4-Benzyl-3-propionyloxazolidin-2-one (R)-3-(1-Oxopropyl)-4-(phenylMethyl)-2-oxazolidinone (R)-3-(1-Oxopropyl)-4-b R-4-Benzyl-3-Propiony-2-Oxazolidinone (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone≥ 99% (HPLC) (R)-4-Benzyl-3-propionyl-2-oxazolidinone,99%e.e. (4R)-4-benzyl-3-propanoyl-1,3-oxazolidin-2 (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone, ee: 99% (R)-4-Benzyl-3-propionyloxazolidin-2-one 97% (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone > 2-Oxazolidinone, 3-(1-oxopropyl)-4-(phenylmethyl)-, (4R)- (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE USP/EP/BP (R)-4-benzy1-3-propionyloxazolidin-2-one (R)-4-benzyl-3-propionyloxazolidin-2-one 99.72%( (R)?-?(-?)?-?4-?Benzyl-?3-?propionyl-?2-?oxazolidinone) (R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone 131685-53-5 Chiral Building Blocks Asymmetric Synthesis Glycidyl Compounds, etc. (Chiral) Oxazolidinone Derivatives Chiral Auxiliaries Aromatics Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Oxazolidinone chiral Asymmetric Synthesis Chiral Building Blocks Glycidyl Compounds, etc. (Chiral) Synthetic Organic Chemistry Peptide Asymmetric Synthesis Chiral Auxiliaries Oxazolidinone Derivatives