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ChemicalBook >> CAS DataBase List >>(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE Structure
(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE structure
CAS No.
131685-53-5
Chemical Name:
(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE
Synonyms
(R)-3-(1-Oxopropyl)-4-b;R-4-Benzyl-3-Propiony-2-Oxazolidinone;N-PROPIONYL-(4R)-BENZYL-2-OXAZOLIDINONE;(R)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE;(-)-4-Benzyl-3-propionyl-2-oxazolidinone;(R)-4-benzy1-3-propionyloxazolidin-2-one;(4R)-4-Benzyl-3-propionyloxazolidin-2-one;N-3-PROPIONYL-(4R)-BENZYL-2-OXAZOLIDINONE;(4R)-4-benzyl-3-propanoyl-1,3-oxazolidin-2;(R)-(-)-4-Benzyl-3-propiomyl-2-oxazolidinone
CBNumber:
CB1217072
Molecular Formula:
C13H15NO3
Molecular Weight:
233.26
MDL Number:
MFCD00269687
MOL File:
131685-53-5.mol
Last updated:2025-07-24 18:13:42
Product description Number Pack Size Price
(R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone 99% 459542 1g $54.2
(R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone 99% 459542 5g $224
(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone >98.0%(GC) B2165 1g $79
(R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone >98.0%(GC) B2165 5g $236
(R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone 99% 459542 25g $1090
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(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE Properties

Melting point 45 °C
Boiling point 396.6±11.0 °C(Predicted)
Density 1.206±0.06 g/cm3(Predicted)
refractive index -103 ° (C=1, EtOH)
storage temp. Inert atmosphere,Room Temperature
solubility Chloroform, Ethanol
pka -2.35±0.40(Predicted)
form Solid
color Off-White
optical activity [α]20/D 102°, c = 1 in ethanol
InChI InChI=1S/C13H15NO3/c1-2-12(15)14-11(9-17-13(14)16)8-10-6-4-3-5-7-10/h3-7,11H,2,8-9H2,1H3/t11-/m1/s1
InChIKey WHOBYFHKONUTMW-LLVKDONJSA-N
SMILES O1C[C@@H](CC2=CC=CC=C2)N(C(=O)CC)C1=O
CAS DataBase Reference 131685-53-5(CAS DataBase Reference)
UNSPSC Code 12352005
NACRES NA.22

SAFETY

Risk and Safety Statements

Hazard Codes  Xi,Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36-24/25
WGK Germany  3
HS Code  29349990

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 459542 (R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone 99% 131685-53-5 1g $54.2 2023-01-07 Buy
Sigma-Aldrich 459542 (R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone 99% 131685-53-5 5g $224 2023-01-07 Buy
TCI Chemical B2165 (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone >98.0%(GC) 131685-53-5 1g $79 2025-07-31 Buy
TCI Chemical B2165 (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone >98.0%(GC) 131685-53-5 5g $236 2025-07-31 Buy
Sigma-Aldrich 459542 (R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone 99% 131685-53-5 25g $1090 2023-06-20 Buy
Product number Packaging Price Buy
459542 1g $54.2 Buy
459542 5g $224 Buy
B2165 1g $79 Buy
B2165 5g $236 Buy
459542 25g $1090 Buy

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE is a oxazolidinone derivative used in the preparation of anisomycin analogues as activators of the JNK/SAPK1 and p38/SAPK2 pathways.

Uses

(R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone can be used as a building block for the preparation of methyl 3-[(S)-3-((R)-4-benzyl-2-oxooxazolidin-3-yl)-2-methyl-3-oxopropyl]benzoate by treating with strong base followed by the addition of methyl 3-bromomethyl benzoate.

General Description

(R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone is used as a building block in organic synthesis for the preparation of oxazolidinone derivatives.

Synthesis

(S)-4-Benzyl-2-oxazolidinone

90719-32-7

Propionyl chloride

79-03-8

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE

131685-53-5

Under nitrogen protection, (S)-4-benzyl-2-azolidinone (800 mg, 4.5 mmol) was dissolved in a dry reaction vial of anhydrous tetrahydrofuran (30 mL) and cooled to -78 °C in a dry ice/acetone bath. A hexane solution of 1.6 M n-butyllithium (5.0 mmol, 3.1 mL) was added slowly and dropwise over 3 min. After stirring for 30 min, propionyl chloride (5.0 mmol, 0.43 mL) was added slowly over 3 min. The reaction solution was slowly warmed to room temperature over 14 h. The reaction was subsequently quenched by the addition of saturated ammonium chloride solution (10 mL) and water (30 mL). The aqueous layer was extracted with ethyl acetate (3 x 40 mL), the organic phases were combined and dried over anhydrous magnesium sulfate. The organic phase was concentrated under reduced pressure to afford (R)-(-)-benzyl-3-propionyl-2-oxazolidinone (oil, 1.0 g, 96% yield) with >95% purity by HPLC.1H NMR (500 MHz, CDCl3): δ 7.33 (dd, J1 = 7.4 Hz, J2 = 7.6 Hz, 2H), 7.29 (d, J = 6.9 Hz, 1H) ), 7.21 (d, J = 7.4 Hz, 2H), 4.67 (m, 1H), 4.18 (m, 2H), 3.31 (dd, J1 = 13.3 Hz, J2 = 3.2 Hz, 1H), 2.96 (m, 2H), 2.77 (dd, J1 = 13.3 Hz, J2 = 3.7 Hz, 1H), 1.21 (t, J = 7.4 Hz, 1H). 3H).

References

[1] Chemistry - An Asian Journal, 2011, vol. 6, # 7, p. 1791 - 1799
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 144 - 148
[3] Journal of Organic Chemistry, 2008, vol. 73, # 8, p. 3292 - 3294
[4] Angewandte Chemie - International Edition, 2016, vol. 55, # 13, p. 4252 - 4255
[5] Angew. Chem., 2016, vol. 128, # 13, p. 4324 - 4327,4

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE Preparation Products And Raw materials

Raw materials

(S)-4-Benzyl-2-oxazolidinone Propionic anhydride Propionyl chloride Tetrahydrofuran n-Butyllithium
Hexane

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Preparation Products

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE Suppliers

Global( 213)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29850 58
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Changzhou PBpharmaceutical R&D Co.,Ltd 		0519-83990708 info@pbpharm.com CHINA 498 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 20284 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 sales@afinechem.com China 15131 58
Baoji Guokang Healthchem co.,ltd 		+8615604608665 15604608665 dominicguo@gk-bio.com CHINA 9414 58
Supplier Advantage
career henan chemical co 		58
Changzhou Ansciep Chemical Co., Ltd. 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Changzhou PBpharmaceutical R&D Co.,Ltd 		58
Accela ChemBio Inc. 		58
Alchem Pharmtech,Inc. 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Dideu Industries Group Limited 		58
AFINE CHEMICALS LIMITED 		58
Baoji Guokang Healthchem co.,ltd 		58

View Lastest Price from (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(R)-4-benzy1-3-propionyloxazolidin-2-one pictures 2025-04-04 (R)-4-benzy1-3-propionyloxazolidin-2-one
131685-53-5
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE pictures 2021-08-12 (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE
131685-53-5
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE pictures 2019-07-06 (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE
131685-53-5
 US $1.00 / KG 1KG 99% 200kg Career Henan Chemical Co

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE Spectrum

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE(131685-53-5)1HNMR(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE(131685-53-5)IR

131685-53-5((R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE)Related Search:

(4S)-(+)-4-Benzyl-3-propionyl-2-oxazolidinone (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE (R)-4-BENZYL-3-(3-CYCLOPROPYL-PROPIONYL)-OXAZOLIDIN-2-ONE (R)-4-BENZYL-3-(4-METHYL-PENTANOYL)-OXAZOLIDIN-2-ONE (3S,4R)-4-BENZYL-3-(3-METHYLPENTANOYL)-OXAZOLIDIN-2-ONE
3-[(4-METHOXYPHENYL)ACETYL]-(4R)-(PHENYLMETHYL)-2-OXAZOLIDINONE 3-(2-PHENYLACETYL)-(4R)-(PHENYLMETHYL)-2-OXAZOLIDINONE 3-(4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-hexanoic acid tert-butyl ester (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one (R)-4-BENZYL-3-(3-CYCLOPENTYL-PROPIONYL)-OXAZOLIDIN-2-ONE

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(R)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE N-PROPIONYL-(4R)-BENZYL-2-OXAZOLIDINONE N-3-PROPIONYL-(4R)-BENZYL-2-OXAZOLIDINONE (R)-(-)-4-Benzyl-3-propiomyl-2-oxazolidinone (4R)-4-benzyl-3-propanoyl-1,3-oxazolidin-2-one (-)-4-Benzyl-3-propionyl-2-oxazolidinone (4R)-4-Benzyl-3-propionyl-1,3-oxazolidin-2-one (4R)-4-Benzyl-3-propionyloxazolidin-2-one (R)-3-(1-Oxopropyl)-4-(phenylMethyl)-2-oxazolidinone (R)-3-(1-Oxopropyl)-4-b R-4-Benzyl-3-Propiony-2-Oxazolidinone (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone≥ 99% (HPLC) (R)-4-Benzyl-3-propionyl-2-oxazolidinone,99%e.e. (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE (4R)-4-benzyl-3-propanoyl-1,3-oxazolidin-2 (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone, ee: 99% (R)-4-Benzyl-3-propionyloxazolidin-2-one 97% (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone > 2-Oxazolidinone, 3-(1-oxopropyl)-4-(phenylmethyl)-, (4R)- (R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE USP/EP/BP (R)-4-benzy1-3-propionyloxazolidin-2-one (R)-4-benzyl-3-propionyloxazolidin-2-one 99.72%( (R)?-?(-?)?-?4-?Benzyl-?3-?propionyl-?2-?oxazolidinone) (R)-(?)-4-Benzyl-3-propionyl-2-oxazolidinone 131685-53-5 Chiral Building Blocks Asymmetric Synthesis Glycidyl Compounds, etc. (Chiral) Oxazolidinone Derivatives Chiral Auxiliaries Aromatics Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Oxazolidinone chiral Asymmetric Synthesis Chiral Building Blocks Glycidyl Compounds, etc. (Chiral) Synthetic Organic Chemistry Peptide Asymmetric Synthesis Chiral Auxiliaries Oxazolidinone Derivatives