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(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one

(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one structure

CAS No.: 145589-03-3

Chemical Name:: (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one

Synonyms: (R)-3-(3-Methylbutanoyl)-4-;-4-Benzyl-3-(3-methylbutanoyl);(4R)-4-Benzyl-3-isovaleryloxazolidin-2-one;3-isovaleroyl-4(R)-benzyl-oxazolidin-2-one;4R-Benzyl-3-(3-Methylbutyryl)oxazolidin-2-one;(R)-3-(3-methylbutanoyl)-4-benzyloxazolidin-2-one;(R)-4-benzyl-3-(3-Methylbutanoyl)oxazolidin-2-one;(4R)-4-Benzyl-3-(3-methyl-butyryl)-oxazolidin-2-one;(4R)-4-benzyl-3-(3-Methylbutanoyl)-1,3-oxazolidin-2-one;(4R)-3-(3-Methyl-1-oxobutyl)-4-(phenylMethyl)-2-oxazolidinone

CBNumber:: CB81094208

Molecular Formula:: C15H19NO3

Molecular Weight:: 261.32

MDL Number:: MFCD10566718

MOL File:: 145589-03-3.mol

MSDS File:: SDS

Last updated:2026-07-16 16:37:17

Product description	Number	Pack Size	Price
(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one	241547	100mg	$347
(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one	241547	250mg	$508
(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one	241547	1g	$837
(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one	016628	250mg	$446
(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one	29273	100MG	$201.6

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(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one Properties

Boiling point	412.9±14.0 °C(Predicted)
Density	1.152
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform, Dichloromethane, Ethyl Acetate
pka	-2.33±0.40(Predicted)
form	Solid
color	White
optical activity	Consistent with structure
InChI	InChI=1S/C15H19NO3/c1-11(2)8-14(17)16-13(10-19-15(16)18)9-12-6-4-3-5-7-12/h3-7,11,13H,8-10H2,1-2H3/t13-/m1/s1
InChIKey	JHGXEUXQJIKZMY-CYBMUJFWSA-N
SMILES	O1C[C@@H](CC2=CC=CC=C2)N(C(=O)CC(C)C)C1=O

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Safety Statements	24/25
HS Code	29349990

(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one price More Price(57)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	241547	(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one	145589-03-3	100mg	$347	2026-06-03	Buy
Usbiological	241547	(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one	145589-03-3	250mg	$508	2026-06-03	Buy
Usbiological	241547	(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one	145589-03-3	1g	$837	2026-06-03	Buy
Usbiological	016628	(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one	145589-03-3	250mg	$446	2026-06-03	Buy
Chem-Impex	29273	(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one	145589-03-3	100MG	$201.6	2026-05-19	Buy

Product number	Packaging	Price	Buy
241547	100mg	$347	Buy
241547	250mg	$508	Buy
241547	1g	$837	Buy
016628	250mg	$446	Buy
29273	100MG	$201.6	Buy

(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one (cas# 145589-03-3) is a compound useful in organic synthesis.

Synthesis

90719-32-7

108-12-3

(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one

145589-03-3

GENERAL STEPS: A dichloromethane (100 ml) solution of 4-dimethylaminopyridine (2.55 g, 21.3 mmol) and triethylamine (46.9 ml, 340.8 mmol) was slowly added to a dichloromethane (300 ml) solution of (S)-4-benzyl-2-oxazolidinone (37.7 g, 213 mmol) at 0 °C. Subsequently, a solution of isovaleryl chloride (33.75 ml, 207 mmol) in dichloromethane (50 ml) was added dropwise while keeping the internal temperature below 10 °C. The reaction mixture was stirred at 10 °C for 30 min and then filtered to remove the formed salt. Water (100 ml) was added to the filtrate for phase separation. The organic phase was washed sequentially with water (100 ml) and brine (100 ml), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 53 g of a yellow oily product, which solidified to a solid on standing (95% yield). The product was characterized by 1H NMR (300 MHz, CDCl3, 298 K) and 13C NMR (75 MHz, CDCl3, 298 K) and confirmed to be the target compound 3-isopentanoyl-4(R)-benzyl-2-oxazolidinone.

References

[1] Helvetica Chimica Acta, 2012, vol. 95, # 10, p. 1937 - 1945,9
[2] Patent: WO2011/151442, 2011, A2. Location in patent: Page/Page column 24
[3] Patent: US2013/71899, 2013, A1. Location in patent: Paragraph 0124-0127
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 23, p. 10530 - 10548
[5] Organic Process Research and Development, 2015, vol. 19, # 6, p. 611 - 617

(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one Preparation Products And Raw materials

Raw materials

(S)-4-Benzyl-2-oxazolidinone Isovaleryl chloride Triethylamine Dichloromethane

Preparation Products

(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one Suppliers

Global( 90)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49979	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29792	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52704	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +86-18949823763	sales@tnjchem.com	China	25356	58
Golden Pharma Co., Limited	+86-18958062155	sales@zjgoldpharm.com	China	5899	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49895	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850 +86-15355479329	market18@leapchem.com	China	43333	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501	product@acmec-e.com	China	33324	58

Supplier	Advantage
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
SIMAGCHEM CORP	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Golden Pharma Co., Limited	58
GIHI CHEMICALS CO.,LIMITED	58
HANGZHOU LEAP CHEM CO., LTD.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58

View Lastest Price from (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-16	(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one 145589-03-3		1KG	99%	1000kgs	Shaanxi Dideu New Materials Co. Ltd
	2020-01-10	(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one 145589-03-3	$1.00	1KG	99%	200kg	Career Henan Chemical Co

(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one
145589-03-3
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one
145589-03-3
$1.00
99%
Career Henan Chemical Co

(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one Spectrum

(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one(145589-03-3)¹HNMR

145589-03-3((R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one)Related Search:

(R)-(-)-4-BENZYL-3-PROPIONYL-2-OXAZOLIDINONE 3-(4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-4-methyl-hexanoic acid tert-butyl ester (3S,4R)-4-BENZYL-3-(3-METHYLPENTANOYL)-OXAZOLIDIN-2-ONE (N-ACETYL)-(4R)-BENZYL-2-OXAZOLIDINONE (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one

4-Benzyl-3-(3-methyl-butyryl)-oxazolidin-2-one

1of2

(R)-3-(3-methylbutanoyl)-4-benzyloxazolidin-2-one 3-isovaleroyl-4(R)-benzyl-oxazolidin-2-one (4R)-4-benzyl-3-(3-Methylbutanoyl)-1,3-oxazolidin-2-one 3-(3-Methyl-1-oxobutyl)-4-(p henylMethyl)-, (R)-2-Oxazolidinone (4R)-3-(3-Methyl-1-oxobutyl)-4-(phenylMethyl)-2-oxazolidinone (4R)-4-Benzyl-3-isovaleryloxazolidin-2-one 4R-Benzyl-3-(3-Methylbutyryl)oxazolidin-2-one Oxazolidinone, 3-(3-methyl-1-oxobutyl)-4-(phenylmethyl)-, (4R)- 2-Oxazolidinone, 3-(3-Methyl-1-oxobutyl)-4-(phenylMethyl)-, (R)- 2-Oxazolidinone,3-(3-Methyl-1-oxobutyl)-4-(phenylMethyl)-, (4R)- -4-Benzyl-3-(3-methylbutanoyl) (R)-4-benzyl-3-(3-Methylbutanoyl)oxazolidin-2-one (4R)-4-Benzyl-3-(3-methyl-butyryl)-oxazolidin-2-one (R)-3-(3-Methylbutanoyl)-4- 145589-03-3 Aromatics Chiral Reagents Miscellaneous Reagents