(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one
- CAS No.
- 145589-03-3
- Chemical Name:
- (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one
- Synonyms
- (R)-3-(3-Methylbutanoyl)-4-;-4-Benzyl-3-(3-methylbutanoyl);(4R)-4-Benzyl-3-isovaleryloxazolidin-2-one;3-isovaleroyl-4(R)-benzyl-oxazolidin-2-one;4R-Benzyl-3-(3-Methylbutyryl)oxazolidin-2-one;(R)-3-(3-methylbutanoyl)-4-benzyloxazolidin-2-one;(R)-4-benzyl-3-(3-Methylbutanoyl)oxazolidin-2-one;(4R)-4-Benzyl-3-(3-methyl-butyryl)-oxazolidin-2-one;(4R)-4-benzyl-3-(3-Methylbutanoyl)-1,3-oxazolidin-2-one;(4R)-3-(3-Methyl-1-oxobutyl)-4-(phenylMethyl)-2-oxazolidinone
- CBNumber:
- CB81094208
- Molecular Formula:
- C15H19NO3
- Molecular Weight:
- 261.32
- MDL Number:
- MFCD10566718
- MOL File:
- 145589-03-3.mol
- MSDS File:
- SDS
| Boiling point | 412.9±14.0 °C(Predicted) |
|---|---|
| Density | 1.152 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Dichloromethane, Ethyl Acetate |
| pka | -2.33±0.40(Predicted) |
| form | Solid |
| color | White |
| optical activity | Consistent with structure |
| InChI | InChI=1S/C15H19NO3/c1-11(2)8-14(17)16-13(10-19-15(16)18)9-12-6-4-3-5-7-12/h3-7,11,13H,8-10H2,1-2H3/t13-/m1/s1 |
| InChIKey | JHGXEUXQJIKZMY-CYBMUJFWSA-N |
| SMILES | O1C[C@@H](CC2=CC=CC=C2)N(C(=O)CC(C)C)C1=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Safety Statements | 24/25 |
| HS Code | 29349990 |
(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 241547 | (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one | 145589-03-3 | 100mg | $347 | 2026-06-03 | Buy |
| Usbiological | 241547 | (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one | 145589-03-3 | 250mg | $508 | 2026-06-03 | Buy |
| Usbiological | 241547 | (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one | 145589-03-3 | 1g | $837 | 2026-06-03 | Buy |
| Usbiological | 016628 | (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one | 145589-03-3 | 250mg | $446 | 2026-06-03 | Buy |
| Chem-Impex | 29273 | (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one | 145589-03-3 | 100MG | $201.6 | 2026-05-19 | Buy |
(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one Chemical Properties, Uses, Production
Chemical Properties
White Solid
Uses
(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one (cas# 145589-03-3) is a compound useful in organic synthesis.
Synthesis
90719-32-7
108-12-3
145589-03-3
GENERAL STEPS: A dichloromethane (100 ml) solution of 4-dimethylaminopyridine (2.55 g, 21.3 mmol) and triethylamine (46.9 ml, 340.8 mmol) was slowly added to a dichloromethane (300 ml) solution of (S)-4-benzyl-2-oxazolidinone (37.7 g, 213 mmol) at 0 °C. Subsequently, a solution of isovaleryl chloride (33.75 ml, 207 mmol) in dichloromethane (50 ml) was added dropwise while keeping the internal temperature below 10 °C. The reaction mixture was stirred at 10 °C for 30 min and then filtered to remove the formed salt. Water (100 ml) was added to the filtrate for phase separation. The organic phase was washed sequentially with water (100 ml) and brine (100 ml), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 53 g of a yellow oily product, which solidified to a solid on standing (95% yield). The product was characterized by 1H NMR (300 MHz, CDCl3, 298 K) and 13C NMR (75 MHz, CDCl3, 298 K) and confirmed to be the target compound 3-isopentanoyl-4(R)-benzyl-2-oxazolidinone.
References
[1] Helvetica Chimica Acta, 2012, vol. 95, # 10, p. 1937 - 1945,9
[2] Patent: WO2011/151442, 2011, A2. Location in patent: Page/Page column 24
[3] Patent: US2013/71899, 2013, A1. Location in patent: Paragraph 0124-0127
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 23, p. 10530 - 10548
[5] Organic Process Research and Development, 2015, vol. 19, # 6, p. 611 - 617
(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong Huakang Medicine Technology Co.,Ltd. | 18912220755 | 249125764@qq.com | China | 21 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 |
View Latest Price from (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-16 | (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one
145589-03-3
|
1KG | 99% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2020-01-10 | (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one
145589-03-3
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one
145589-03-3
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- (R)-3-(3-Methylbutanoyl)-4-benzyloxazolidin-2-one
145589-03-3
- $1.00
- 99%
- Career Henan Chemical Co
