5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid
![5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid Structure](CAS/GIF/118414-59-8.gif)
- CAS No.
- 118414-59-8
- Chemical Name:
- 5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid
- Synonyms
- NTZDPA;5-Chloro-1-(4-chlorobenzyl)-3-(phenylthio)-1H-indole-2-carboxylic acid;5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid;1H-Indole-2-carboxylic acid, 5-chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-
- CBNumber:
- CB1224807
- Molecular Formula:
- C22H15Cl2NO2S
- Molecular Weight:
- 428.33
- MDL Number:
- MFCD06798322
- MOL File:
- 118414-59-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | Store at +4°C |
|---|---|
| solubility | DMSO: soluble15mg/mL, clear |
| form | powder |
| color | white to beige |
| InChI | 1S/C22H15Cl2NO2S/c23-15-8-6-14(7-9-15)13-25-19-11-10-16(24)12-18(19)21(20(25)22(26)27)28-17-4-2-1-3-5-17/h1-12H,13H2,(H,26,27) |
| InChIKey | VUPOTURDKDMIGQ-UHFFFAOYSA-N |
| SMILES | S(c4ccccc4)c1c2c([n](c1C(=O)O)Cc3ccc(cc3)Cl)ccc(c2)Cl |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0616 | nTZDpa ≥98% (HPLC) | 118414-59-8 | 5mg | $112 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML0616 | nTZDpa ≥98% (HPLC) | 118414-59-8 | 25mg | $484 | 2023-06-20 | Buy |
| Usbiological | 256070 | nTZDpa Asreported | 118414-59-8 | 10mg | $432 | 2026-06-03 | Buy |
| Usbiological | 256070 | nTZDpa Asreported | 118414-59-8 | 50mg | $1140 | 2026-06-03 | Buy |
| Biosynth | TEA41459 | nTZDpa | 118414-59-8 | 50mg | $828.5 | 2026-06-05 | Buy |
5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid Chemical Properties, Uses, Production
Uses
nTZDpa is a PPARγ agonist, with pharmaceutical applications such as anti-diabetic drugs.
Biological Activity
Potent, selective non-thiazolidinedione PPAR γ partial agonist (EC 50 = 57 nM); produces ~25% maximum efficacy. Antagonizes full agonist activity by ~60% (IC 50 ~ 285 nM). Displays no activity at PPAR α or PPAR δ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPAR γ agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo .
storage
Store at +4°C
5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8039 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66028182 17714375163 | yftan@aikonchem.com | China | 16674 | 50 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 5731 | 55 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 | sales@rrkchem.com | China | 57336 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 5000 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
