3-PIPERIDINEACETIC ACID, 1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-OXO-, 1,1-DIMETHYLETHYL ESTER
![3-PIPERIDINEACETIC ACID, 1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-OXO-, 1,1-DIMETHYLETHYL ESTER Structure](CAS2/GIF/1010814-94-4.gif)
- CAS No.
- 1010814-94-4
- Chemical Name:
- 3-PIPERIDINEACETIC ACID, 1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-OXO-, 1,1-DIMETHYLETHYL ESTER
- Synonyms
- tert-Butyl 3-(2-(tert-butoxy);tert-Butyl 2-(1-Boc-4-oxopiperidin-3-yl)acetate;3-(2-tert-butoxy-2-oxoethyl)-4-oxopiperidine-1-carboxylate;tert-butyl 3-(2-tert-butoxy-2-oxoethyl)-4-oxopiperidine-1-carboxylate;tert-Butyl 3-(2-(tert-butoxy)-2-oxoethyl)-4-oxopiperidine-1-carboxylate 97%;1,1-Dimethylethyl 1-[(1,1-dimethylethoxy)carbonyl]-4-oxo-3-piperidineacetate;tert-butyl 3-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-4-oxopiperidine-1-carboxylate;3-PIPERIDINEACETIC ACID, 1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-OXO-, 1,1-DIMETHYLETHYL ESTER
- CBNumber:
- CB12456303
- Molecular Formula:
- C16H27NO5
- Molecular Weight:
- 313.39
- MDL Number:
- MFCD11111810
- MOL File:
- 1010814-94-4.mol
| Product description | Number | Pack Size | Price |
| tert-Butyl3-(2-(tert-Butoxy)-2-oxoethyl)-4-oxopiperidine-1-Carboxylate | B701905 | 100mg | $265 |
| tert-Butyl 3-(2-(tert-butoxy)-2-oxoethyl)-4-oxopiperidine-1-carboxylate | 4H56-1-310 | 250mg | $303 |
| tert-Butyl 3-(2-(tert-butoxy)-2-oxoethyl)-4-oxopiperidine-1-carboxylate 97% | OR315309 | 100mg | $160 |
| tert-Butyl 3-(2-(tert-butoxy)-2-oxoethyl)-4-oxopiperidine-1-carboxylate | 4H56-1-310 | 100mg | $189 |
| TERT-BUTYL-3-(2-(TERT-BUTOXY)-2-OXOETHYL)-4-OXOPIPERIDINE-1-CARBOXYLATE 95.00% | CHM0394005 | 5MG | $496.86 |
3-PIPERIDINEACETIC ACID, 1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-OXO-, 1,1-DIMETHYLETHYL ESTER price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | B701905 | tert-Butyl3-(2-(tert-Butoxy)-2-oxoethyl)-4-oxopiperidine-1-Carboxylate | 1010814-94-4 | 100mg | $265 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H56-1-310 | tert-Butyl 3-(2-(tert-butoxy)-2-oxoethyl)-4-oxopiperidine-1-carboxylate | 1010814-94-4 | 250mg | $303 | 2021-12-16 | Buy |
| Apolloscientific | OR315309 | tert-Butyl 3-(2-(tert-butoxy)-2-oxoethyl)-4-oxopiperidine-1-carboxylate 97% | 1010814-94-4 | 100mg | $160 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H56-1-310 | tert-Butyl 3-(2-(tert-butoxy)-2-oxoethyl)-4-oxopiperidine-1-carboxylate | 1010814-94-4 | 100mg | $189 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0394005 | TERT-BUTYL-3-(2-(TERT-BUTOXY)-2-OXOETHYL)-4-OXOPIPERIDINE-1-CARBOXYLATE 95.00% | 1010814-94-4 | 5MG | $496.86 | 2021-12-16 | Buy |
3-PIPERIDINEACETIC ACID, 1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-OXO-, 1,1-DIMETHYLETHYL ESTER Chemical Properties,Uses,Production
Synthesis
5292-43-3
![3-PIPERIDINEACETIC ACID, 1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-OXO-, 1,1-DIMETHYLETHYL ESTER](/CAS2/GIF/1010814-94-4.gif)
1010814-94-4
To a tetrahydrofuran (THF, 300 mL) solution of diisopropylamine (13.5 mL, 96 mmol) was slowly added n-butyllithium (n-BuLi, 2.5 M in hexane, 32 mL) dropwise at -78 °C. The reaction mixture was slowly warmed to -10 °C and then cooled to -78 °C again. Subsequently, a solution of tert-butyl 4-oxopiperidine-1-carboxylate (10 g, 50 mmol) in THF (50 mL) was added dropwise and stirring was continued for 15 min at -78 °C. Next, a mixed solution of tert-butyl bromoacetate (12.6 mL, 85 mmol) with HMPT (5 mL) in THF (30 mL) was added dropwise, and the reaction mixture was stirred at -78 °C for 4 h before slowly warming up to room temperature. The reaction mixture was quenched with saturated aqueous ammonium chloride (NH4Cl) and extracted with ethyl acetate (EA). After post-treatment and purification by column chromatography (eluent: n-hexane/ethyl acetate=4:1), the target product tert-butyl 3-(2-tert-butoxy-2-oxoethyl)-4-oxopiperidine-1-carboxylate was obtained as 7.6 g (50.6% yield, yellow oil).1H NMR (CDCl3) δ: 4.40-4.20 (m, 2H); 3.25-3.15 (m, 1H). 1H); 3.00-2.80 (m, 2H); 2.70-2.40 (m, 3H); 2.30-2.10 (m, 1H); 1.51 (s, 9H), 1.46 (s, 9H).
References
[1] Patent: WO2008/26172, 2008, A1. Location in patent: Page/Page column 63
3-PIPERIDINEACETIC ACID, 1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-OXO-, 1,1-DIMETHYLETHYL ESTER Preparation Products And Raw materials
Raw materials
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Preparation Products
3-PIPERIDINEACETIC ACID, 1-[(1,1-DIMETHYLETHOXY)CARBONYL]-4-OXO-, 1,1-DIMETHYLETHYL ESTER Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
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| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2208 | 55 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7892 | 64 |
| SynAsst Chemical. | 021-60343070 | China | 12740 | 55 | |
| Zhengzhou AiXi Technology Co., Ltd. | 0371-56787280 13137706083 | m18539565376@163.com | China | 970 | 55 |
| Aikon International Limited | 025-66113011 13155353615 | qzhang@aikonchem.com | China | 15393 | 58 |
| Shandong utilizing biological technology co., LTD | 15966937598 | 3407650895@qq.com | China | 5063 | 58 |
