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tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate

tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate structure

CAS No.: 392331-66-7

Chemical Name:: tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate

Synonyms: 4-Aminomethyl-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester;1-Boc-4-(Aminomethyl);1-Boc-4-aMinoMethyl-4-hyd...;4-Aminomethyl-1-Boc-piperidin-4-ol;4-Aminomethyl-1-Boc-4-hydroxypiperidine,97%;4-AMinoMethyl-1-Boc-4-hydroxypiperidine, 97%;tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate;tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate 95%;1-Piperidinecarboxylic acid, 4-(aminomethyl)-4-hydroxy-, 1,1-dimethylethyl ester

CBNumber:: CB12470392

Molecular Formula:: C11H22N2O3

Molecular Weight:: 230.3

MDL Number:: MFCD11579803

MOL File:: 392331-66-7.mol

MSDS File:: SDS

Last updated:2026-05-27 23:16:11

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tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Properties

Boiling point	341.0±27.0 °C(Predicted)
Density	1.124
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	12.48±0.20(Predicted)
form	Solid
color	Off-white
Water Solubility	Slightly soluble in water.
Sensitive	Air Sensitive
InChI	InChI=1S/C11H22N2O3/c1-10(2,3)16-9(14)13-6-4-11(15,8-12)5-7-13/h15H,4-8,12H2,1-3H3
InChIKey	XYWCDAFPRBDRER-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCC(CN)(O)CC1
CAS DataBase Reference	392331-66-7

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

HazardClass

IRRITANT

HS Code

2933399990

NFPA 704

	1
2		0

tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate price More Price(54)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	OR315339	tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate >98%	392331-66-7	250mg	$21	2026-06-04	Buy
Apolloscientific	OR315339	tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate >98%	392331-66-7	1g	$22	2026-06-04	Buy
Apolloscientific	OR315339	tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate >98%	392331-66-7	5g	$67	2026-06-04	Buy
Apolloscientific	OR315339	tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate >98%	392331-66-7	25g	$277	2026-06-04	Buy
Apolloscientific	OR315339	tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate >98%	392331-66-7	100g	$1099	2026-06-04	Buy

Product number	Packaging	Price	Buy
OR315339	250mg	$21	Buy
OR315339	1g	$22	Buy
OR315339	5g	$67	Buy
OR315339	25g	$277	Buy
OR315339	100g	$1099	Buy

tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Chemical Properties, Uses, Production

Uses

4-Aminomethyl-1-Boc-4-hydroxypiperidine can be used in agrochemical, pharmaceutical and dyestuff.

Synthesis

1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

147804-30-6

392331-66-7

General procedure for the synthesis of tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate from tert-butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate: In a 100 mL sealed tube, a magnetic stirring bar, tert-butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate (300 mg, 1.28 mmol) and 7 M ammonium hydroxide in a methanol solution (20 mL). The reaction mixture was placed in an oil bath at 80°C and stirred for 16 hours. After completion of the reaction, the mixture was cooled to room temperature. The solvent was removed by concentration under reduced pressure to afford the crude product tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate (350 mg, >95% yield), which could be used in the subsequent reaction without further purification.LCMS (ESI) m/z 231 [M + H]+.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 24, p. 7458 - 7461
[2] Patent: US2016/185786, 2016, A1. Location in patent: Paragraph 0679
[3] Patent: WO2015/92804, 2015, A1. Location in patent: Page/Page column 21
[4] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 289 - 301
[5] Patent: WO2014/147636, 2014, A1. Location in patent: Page/Page column 35; 36

tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

1-Boc-4-hydroxy-piperidine-4-carbonitrile 1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid, 1,1-dimethylethyl ester Ammonium hydroxide Methanol

Preparation Products

tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Suppliers

Global Suppliers ( 110)

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Jingmen Pharmaceutical Industry Technology Research Institute Co., Ltd.	18186973118	359311405@qq.com	China	153	58
Shanghai Diluo Technology Co., LTD	19279824758 19526192903	15106284752@163.com	China	174	58
Cangzhou Dimai Technology Co., Ltd	1351-2466848 13512466848	hbdypharm@163.com	China	291	58
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Shanghai Boc Chemical Co.,Ltd	021-34975603-808 18721111801	sales@bocpharma.com	China	991	64
Shanghai Topbiochem Technology Co., Ltd	+86-21-60341587	sales@topbiochem.com	China	6166	58
Shanghai Jian Chao Chemical Technology Co., Ltd.	150-2103-5486 18017383231	983544897@qq.com	China	9335	55
9ding chemical ( Shanghai) Limited	4009209199	sales@9dingchem.com	China	18201	56
Shanghai Raise Chemical Technology Co.,Ltd	+86-021-50935922		China	7854	55

Supplier	Advantage
Hubei Jingmen Pharmaceutical Industry Technology Research Institute Co., Ltd.	58
Shanghai Diluo Technology Co., LTD	58
Cangzhou Dimai Technology Co., Ltd	58
Alfa Aesar	84
Pure Chemistry Scientific Inc.	62
Shanghai Boc Chemical Co.,Ltd	64
Shanghai Topbiochem Technology Co., Ltd	58
Shanghai Jian Chao Chemical Technology Co., Ltd.	55
9ding chemical ( Shanghai) Limited	56
Shanghai Raise Chemical Technology Co.,Ltd	55

View Latest Price from tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-12-24	tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate 392331-66-7		1KG	99.0%	1000 tons	Shaanxi Dideu Medichem Co. Ltd
	2019-07-06	tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate 392331-66-7	$1.00	1KG	95%	500kg	Career Henan Chemical Co

tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate
392331-66-7
$0.10
99.0%
Shaanxi Dideu Medichem Co. Ltd

tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate
392331-66-7
$1.00
95%
Career Henan Chemical Co

tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Spectrum

tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate(392331-66-7)¹HNMR

392331-66-7 (tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate) Related Search:

1-N-Boc-4-aminomethyl-4-phenylpiperidine 4-Aminomethyl-1-Boc-piperidin-4-ol hydrochloride tert-butyl 4-(7-chloro-2-oxo-2,3-dihydro-1H-indol-3-ylidene) piperidine-1-carboxylate tert-butyl 4-(7-bromo-4-methylquinazolin-2-yl)piperidine-1-c arboxylate tert-butyl 4-(aminomethyl)-2,2,4-trimethylpyrrolidine-1-carb oxylate

DL-Pipecolinic acid

1of2

tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate 1-Boc-4-aMinoMethyl-4-hyd... tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate 95% 4-AMinoMethyl-1-Boc-4-hydroxypiperidine, 97% 4-Aminomethyl-1-Boc-piperidin-4-ol 1-Piperidinecarboxylic acid, 4-(aminomethyl)-4-hydroxy-, 1,1-dimethylethyl ester 1-Boc-4-(Aminomethyl) 4-Aminomethyl-1-Boc-4-hydroxypiperidine,97% 4-Aminomethyl-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester 392331-66-7