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tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate

tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate structure

CAS No.: 392331-66-7

Chemical Name:: tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate

Synonyms: 4-Aminomethyl-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester;1-Boc-4-(Aminomethyl);1-Boc-4-aMinoMethyl-4-hyd...;4-Aminomethyl-1-Boc-piperidin-4-ol;4-Aminomethyl-1-Boc-4-hydroxypiperidine,97%;4-AMinoMethyl-1-Boc-4-hydroxypiperidine, 97%;tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate;tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate 95%;1-Piperidinecarboxylic acid, 4-(aminomethyl)-4-hydroxy-, 1,1-dimethylethyl ester

CBNumber:: CB12470392

Molecular Formula:: C11H22N2O3

Molecular Weight:: 230.3

MDL Number:: MFCD11579803

MOL File:: 392331-66-7.mol

MSDS File:: SDS

Last updated:2026-05-27 23:16:11

Product description	Number	Pack Size	Price
tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate >98%	OR315339	250mg	$21
tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate >98%	OR315339	1g	$22
tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate >98%	OR315339	5g	$67
tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate >98%	OR315339	25g	$277
tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate >98%	OR315339	100g	$1099
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tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Properties

Boiling point	341.0±27.0 °C(Predicted)
Density	1.124
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	12.48±0.20(Predicted)
form	Solid
color	Off-white
Water Solubility	Slightly soluble in water.
Sensitive	Air Sensitive
InChI	InChI=1S/C11H22N2O3/c1-10(2,3)16-9(14)13-6-4-11(15,8-12)5-7-13/h15H,4-8,12H2,1-3H3
InChIKey	XYWCDAFPRBDRER-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCC(CN)(O)CC1
CAS DataBase Reference	392331-66-7

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

HazardClass

IRRITANT

HS Code

2933399990

NFPA 704

	1
2		0

tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate price More Price(66)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	OR315339	tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate >98%	392331-66-7	250mg	$21	2026-06-04	Buy
Apolloscientific	OR315339	tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate >98%	392331-66-7	1g	$22	2026-06-04	Buy
Apolloscientific	OR315339	tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate >98%	392331-66-7	5g	$67	2026-06-04	Buy
Apolloscientific	OR315339	tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate >98%	392331-66-7	25g	$277	2026-06-04	Buy
Apolloscientific	OR315339	tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate >98%	392331-66-7	100g	$1099	2026-06-04	Buy

Product number	Packaging	Price	Buy
OR315339	250mg	$21	Buy
OR315339	1g	$22	Buy
OR315339	5g	$67	Buy
OR315339	25g	$277	Buy
OR315339	100g	$1099	Buy

tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Chemical Properties,Uses,Production

Uses

4-Aminomethyl-1-Boc-4-hydroxypiperidine can be used in agrochemical, pharmaceutical and dyestuff.

Synthesis

1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

147804-30-6

392331-66-7

General procedure for the synthesis of tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate from tert-butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate: In a 100 mL sealed tube, a magnetic stirring bar, tert-butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate (300 mg, 1.28 mmol) and 7 M ammonium hydroxide in a methanol solution (20 mL). The reaction mixture was placed in an oil bath at 80°C and stirred for 16 hours. After completion of the reaction, the mixture was cooled to room temperature. The solvent was removed by concentration under reduced pressure to afford the crude product tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate (350 mg, >95% yield), which could be used in the subsequent reaction without further purification.LCMS (ESI) m/z 231 [M + H]+.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 24, p. 7458 - 7461
[2] Patent: US2016/185786, 2016, A1. Location in patent: Paragraph 0679
[3] Patent: WO2015/92804, 2015, A1. Location in patent: Page/Page column 21
[4] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 289 - 301
[5] Patent: WO2014/147636, 2014, A1. Location in patent: Page/Page column 35; 36

tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Preparation Products And Raw materials

Raw materials

1-BOC-4-HYDROXY-PIPERIDINE-4-CARBONITRILE 1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER Ammonium hydroxide Methanol

Preparation Products

tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Suppliers

Global( 111)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29812	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49979	58
Shaanxi Dideu Medichem Co. Ltd	+86-17392712779	1097@dideu.com	China	3992	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
NINGBOBENKANGJS PHARMTECHCO., LTD	+8615990591583 15990591583		CHINA	2029	58
Apeloa Pharmaceutical Co., Ltd.	+86-0571-87635730 +8615858229168	chem1022@hengdian-group.com	China	1478	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9911	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
NINGBOBENKANGJS PHARMTECHCO., LTD	58
Apeloa Pharmaceutical Co., Ltd.	58
Hefei Hirisun Pharmatech Co., Ltd	58

View Lastest Price from tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-12-24	tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate 392331-66-7		1KG	99.0%	1000 tons	Shaanxi Dideu Medichem Co. Ltd
	2019-07-06	tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate 392331-66-7	$1.00	1KG	95%	500kg	Career Henan Chemical Co

tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate
392331-66-7
$0.10
99.0%
Shaanxi Dideu Medichem Co. Ltd

tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate
392331-66-7
$1.00
95%
Career Henan Chemical Co

tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate Spectrum

tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate(392331-66-7)¹HNMR

392331-66-7(tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate)Related Search:

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DL-Pipecolinic acid

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tert-butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate 1-Boc-4-aMinoMethyl-4-hyd... tert-Butyl 4-(aminomethyl)-4-hydroxypiperidine-1-carboxylate 95% 4-AMinoMethyl-1-Boc-4-hydroxypiperidine, 97% 4-Aminomethyl-1-Boc-piperidin-4-ol 1-Piperidinecarboxylic acid, 4-(aminomethyl)-4-hydroxy-, 1,1-dimethylethyl ester 1-Boc-4-(Aminomethyl) 4-Aminomethyl-1-Boc-4-hydroxypiperidine,97% 4-Aminomethyl-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester 392331-66-7