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ChemicalBook >> CAS DataBase List >>1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid, 1,1-dimethylethyl ester

1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid, 1,1-dimethylethyl ester

1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid, 1,1-dimethylethyl ester Structure
1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid, 1,1-dimethylethyl ester structure
CAS No.
147804-30-6
Chemical Name:
1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid, 1,1-dimethylethyl ester
Synonyms
t-Butyl 1-Oxa-6-azaspiro[2.5]octane-6-carboxylate;N-Boc-1-oxa-6-azaspiro[2.5]octane;6-Boc-1-oxa-6-azaspiro[2.5]octane,97%;1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID;N-Boc-1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid;6-(tert-Butoxycarbonyl)-1-oxa-6-azaspiro[2.5]octane;tert-Butyl 1-oxa-6-azaspiro[2.5]octan-6-carboxylate;6-Aza-1-oxaspiro[2.5]octane-6-carboxylic acid tert-butyl ester;1-Oxa-6-aza-spiro[2.5]octan-6-carboxylic acid tert-butyl ester;2-oxa-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester
CBNumber:
CB5704293
Molecular Formula:
C11H19NO3
Molecular Weight:
213.27
MDL Number:
MFCD07779385
MOL File:
147804-30-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:53:40
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1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid, 1,1-dimethylethyl ester Properties

Melting point 50-52℃
Boiling point 297.6±33.0 °C(Predicted)
Density 1.12
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka -0.82±0.20(Predicted)
form Crystalline Powder
color White
InChI InChI=1S/C11H19NO3/c1-10(2,3)15-9(13)12-6-4-11(5-7-12)8-14-11/h4-8H2,1-3H3
InChIKey ULSBMKGFFFMGOI-UHFFFAOYSA-N
SMILES O1C2(CCN(C(OC(C)(C)C)=O)CC2)C1
UNSPSC Code 12352108
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-26-36/37/39-45
HazardClass  IRRITANT
HS Code  29349990
Storage Class 11 - Combustible Solids
NFPA 704
1
2 0

1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid, 1,1-dimethylethyl ester price More Price(71)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SYX00064 1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester Aldrich 147804-30-6 1g $429 2026-04-30 Buy
TCI Chemical B5501 tert-Butyl 1-Oxa-6-azaspiro[2.5]octane-6-carboxylate >97.0%(GC) 147804-30-6 1g $89 2026-04-30 Buy
TCI Chemical B5501 tert-Butyl 1-Oxa-6-azaspiro[2.5]octane-6-carboxylate >97.0%(GC) 147804-30-6 5g $311 2026-04-30 Buy
Usbiological 410208 1-Oxa-6-azaspiro[2.5]octane-6-carboxylic Acid tert-Butyl Ester 147804-30-6 250mg $305 2026-06-03 Buy
Usbiological 410208 1-Oxa-6-azaspiro[2.5]octane-6-carboxylic Acid tert-Butyl Ester 147804-30-6 1g $396 2026-06-03 Buy
Product number Packaging Price Buy
SYX00064 1g $429 Buy
B5501 1g $89 Buy
B5501 5g $311 Buy
410208 250mg $305 Buy
410208 1g $396 Buy

1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid, 1,1-dimethylethyl ester Chemical Properties, Uses, Production

Uses

1-Oxa-6-azaspiro[2.5]octane-6-carboxylic Acid tert-Butyl Ester is used in the synthesis of a T-type Ca2+ channel antagonist, 4-Aminomethyl-4-fluoropiperidine.

Synthesis

N-(tert-Butoxycarbonyl)-4-piperidone

79099-07-3

1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

147804-30-6

General procedure for the synthesis of tert-butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate from N-tert-butoxycarbonyl-4-piperidone: [Reference Example 1] Synthesis of tert-butyl 6-azaspiro[2.5]octane-6-carboxylate. 60% NaH-oil packet (5.28 g, 132 mmol) was suspended in dimethylsulfoxide (DMSO) (250 mL) and after cooling to 0°C, trimethylsulfonium iodide (29.0 g, 132 mmol) was added. The reaction mixture was warmed to room temperature and stirred for 40 min. Subsequently, N-Boc-4-piperidone (Boc = tert-butoxycarbonyl) (25.0 g, 125 mmol) was added and the reaction mixture was stirred at room temperature for 1 hr and then at 55 °C for 1.5 hrs. After completion of the reaction, the mixture was poured into ice-cooled water (500 mL) and extracted with ethyl acetate (AcOEt) (500 mL × 3 times). The ethyl acetate layers were combined, washed with water, then with saturated brine and finally dried with anhydrous Na2SO4. After filtration, the filtrate was concentrated to give tert-butyl 6-aza-1-oxaspiro[2.5]octane-6-carboxylate. The product was structurally confirmed by 1H-NMR. The yield was 26.4 g (99%).1H-NMR (270 MHz, CDCl3): δ 1.40-1.49 (m, 2H), 1.46 (s, 9H), 1.74-1.85 (m, 2H), 2.69 (s, 2H), 3.37-3.48 (m, 2H), 3.68-3.77 (m, 2H).

References

[1] Patent: EP1505067, 2005, A1. Location in patent: Page/Page column 368
[2] Patent: WO2008/10765, 2008, A1. Location in patent: Page/Page column 66-67
[3] Patent: US2010/4239, 2010, A1. Location in patent: Page/Page column 93
[4] Patent: WO2005/49620, 2005, A1. Location in patent: Page/Page column 24
[5] Patent: CN108727400, 2018, A. Location in patent: Paragraph 0115; 0118; 0120

1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid, 1,1-dimethylethyl ester Preparation Products And Raw materials

Raw materials

Trimethylsulfoxonium iodide 4-Vinyl-piperidine Trimethylsulfonium iodide 4-Methylenepiperidine tert-Butyl 4-methylenepiperidine-1-carboxylate
Sulfur, iodotrimethyloxo- 3-Chloroperoxybenzoic acid N-(tert-Butoxycarbonyl)-4-piperidone Water Dimethyl sulfoxide

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Preparation Products

4-Aminomethyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester tert-butyl 4-(azidomethyl)-4-hydroxypiperidine-1-carboxylate 4-Piperidinol, 4-(2-propyn-1-yl)-

1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid, 1,1-dimethylethyl ester Suppliers

Global Suppliers ( 211)
Supplier Tel Email Country ProdList Advantage
Hubei Jingmen Pharmaceutical Industry Technology Research Institute Co., Ltd. 18186973118 359311405@qq.com China 153 58
Shanghai Diluo Technology Co., LTD 19279824758 19526192903 15106284752@163.com China 174 58
Shanghai Balmxy Pharmaceutical Co., Ltd 021-24206007 13764915196 sales@balmxy.com China 6959 55
Shanghai Hobor Chemical Co., Ltd 13918007836 sales@hoborchem.com China 423 60
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Tetranov Biopharm 13526569071 sales@leadmedpharm.com China 7881 64
Supplier Advantage
Hubei Jingmen Pharmaceutical Industry Technology Research Institute Co., Ltd. 58
Shanghai Diluo Technology Co., LTD 58
Shanghai Balmxy Pharmaceutical Co., Ltd 55
Shanghai Hobor Chemical Co., Ltd 60
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Jia Xing Isenchem Co.,Ltd 66
Tetranov Biopharm 64

View Latest Price from 1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid, 1,1-dimethylethyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
tert-Butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate pictures 2026-08-25 tert-Butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate
147804-30-6
 $1.60-6.60 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER pictures 2019-07-06 1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
147804-30-6
 $1.00 1kg 95%-99% 100kg Career Henan Chemical Co

1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid, 1,1-dimethylethyl ester Spectrum

1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER(147804-30-6)1HNMR

147804-30-6 (1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid, 1,1-dimethylethyl ester) Related Search:

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1-Oxa-6-aza-spiro[2.5]octan-6-carboxylic acid tert-butyl ester 6-Aza-1-oxaspiro[2.5]octane-6-carboxylic acid tert-butyl ester 1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID N-Boc-1-oxa-6-azaspiro[2.5]octane tert-Butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate, 6-(tert-Butoxycarbonyl)-1-oxa-6-azaspiro[2.5]octane 1-oxa-6-aza-spiro-[2.5]octane-6-caboxylic acid tert-butyl ester N-Boc-1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid 1-oxy-6-azaspiro[2.5]-octane-6-carboxylic acid, 1,1-dimethylethylester 2-oxa-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester 6-Boc-1-oxa-6-azaspiro[2.5]octane,97% t-Butyl 1-Oxa-6-azaspiro[2.5]octane-6-carboxylate 6-(tert-Butoxycarbonyl)-1-oxa-6-azaspiro[2.5]octane 1-oxa-6-azaspiro[2.5]octane-6-carboxylic acid, 1,1-dimethyle... 1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid, 1,1-dimethylethyl ester (9CI, ACI) 1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester - [O1979] tert-Butyl 1-oxa-6-azaspiro[2.5]octan-6-carboxylate 1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid, 1,1-dimethylethyl ester 147804-30-6 1 other