Pexacerfont
- CAS No.
- 459856-18-9
- Chemical Name:
- Pexacerfont
- Synonyms
- BMS-562086;Pexacerfont;Pexacerfont/BMS-562086;Pexacerfont, 10 mM in DMSO;N-[(2R)-butan-2-yl]-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethylpyrazolo[1,5-a][1,3,5]triazin-4-amine;8-(6-Methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,5-a]-1,3,5-triazin-4-amine;Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-(6-methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]-
- CBNumber:
- CB22563437
- Molecular Formula:
- C18H24N6O
- Molecular Weight:
- 340.42
- MDL Number:
- MFCD22628864
- MOL File:
- 459856-18-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Pexacerfont ≥98% | 33221 | 1mg | $41 |
| Pexacerfont ≥98% | 33221 | 5mg | $178 |
| Pexacerfont ≥98% | 33221 | 10mg | $274 |
| 8-(6-Methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,5-a]-1,3,5-triazin-4-amine 99% | AA00DJML | 1mg | $29 |
| 8-(6-Methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,5-a]-1,3,5-triazin-4-amine 99% | AA00DJML | 5mg | $64 |
| Melting point | 118℃ |
|---|---|
| Density | 1.24 |
| storage temp. | 2-8°C(protect from light) |
| solubility | DMSO: 30 mg/ml; Ethanol: 30 mg/ml |
| form | A crystalline solid |
| pka | 2.08±0.12(Predicted) |
| color | White to off-white |
| FDA UNII | LF1VBG4ZUK |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| NFPA 704 |
|
Pexacerfont price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 33221 | Pexacerfont ≥98% | 459856-18-9 | 1mg | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 33221 | Pexacerfont ≥98% | 459856-18-9 | 5mg | $178 | 2026-04-30 | Buy |
| Cayman Chemical | 33221 | Pexacerfont ≥98% | 459856-18-9 | 10mg | $274 | 2026-04-30 | Buy |
| aablocks | AA00DJML | 8-(6-Methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,5-a]-1,3,5-triazin-4-amine 99% | 459856-18-9 | 1mg | $29 | 2026-05-28 | Buy |
| aablocks | AA00DJML | 8-(6-Methoxy-2-methyl-3-pyridinyl)-2,7-dimethyl-N-[(1R)-1-methylpropyl]pyrazolo[1,5-a]-1,3,5-triazin-4-amine 99% | 459856-18-9 | 5mg | $64 | 2026-05-28 | Buy |
Pexacerfont Chemical Properties,Uses,Production
Uses
Pexacerfont is a selective corticotropin-releasing factor (CRF1) receptor antagonist with IC50 of 6.1±0.6 nM for human CRF1 receptor.
Definition
ChEBI: Pexacerfont is a pyrazolopyridine.
in vivo
Pexacerfont (BMS-562086) is active in rats (1-10 mg/kg, orally) in the defensive withdrawal and elevated plus maze models of anxiety. After the intravenous bolus dose, the plasma Pexacerfont concentrations exhibited a multiexponential decline in rats, dogs, and chimpanzees. The CLp of Pexacerfont was higher in rats (17.9 mL/kg per min) and dogs (11.6 mL/kg per min) than in chimpanzees (2.0 mL/kg per min). Assuming the value of CLp of Pexacerfont approximates the value of CLb in these three species, Pexacerfont has an estimated hepatic extraction ratio of 0.32, 0.38, and 0.08 in rats, dogs, and chimpanzees, respectively (calculated by dividing CLp by respective hepatic blood flow, 55.2, 30.9, and 25.5 mL/kg per min for rats, dogs, and chimpanzees). The assumption that CLb is equal to CLp is reasonable at least in rats, where the blood to plasma concentration ratio of BMS-562086-equivalent radioactivity was 0.95 at 1 h postdose[1].
storage
Store at -20°C
References
[1] Zhou L, et al. In vitro and in vivo metabolism and pharmacokinetics of BMS-562086, a potent and orally bioavailable corticotropin-releasing factor-1 receptor antagonist. Drug Metab Dispos. 2012 Jun;40(6):1093-103. DOI:10.1124/dmd.111.043596
Pexacerfont Preparation Products And Raw materials
Raw materials
Preparation Products
Pexacerfont Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49968 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53803 | 58 |
| Shanghai Hanhong Scientific Co., Ltd. | +undefined17612118332 | Lucky@hanhonggroup.com | China | 5844 | 58 |
| Shanghai Fuhe Chemistry Technology Co., Ltd. | 0086-21-67651709 | cfx759@hotmail.com | China | 410 | 57 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4794 | 58 |
