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ChemicalBook >> CAS DataBase List >>N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide Structure
N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide structure
CAS No.
356068-86-5
Chemical Name:
N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
Synonyms
N-[2-(Diethylamino)ethyl]-2,4-dimethyl-5-formyl-1H-pyrrole-3-carboxamide;sunitinib PI-5;Sunitinib Malate 2;N-(2-(Diethylamino);Sunitinib Impurity 3;Sunitinib Impurity 50;Sunitinib EP Impurity-C;N-[2-(Diethylamino)ethyl;Sunitinib Aldehyde Impurity;N-[2-(Diethylamino)ethyl]-5-formyl-
CBNumber:
CB12484863
Molecular Formula:
C14H23N3O2
Molecular Weight:
265.35
MDL Number:
MFCD12913910
MOL File:
356068-86-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 23:17:17
Request For Quotation

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide Properties

Melting point 145-148°C
Boiling point 389.9±42.0 °C(Predicted)
Density 1.096
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Dichloromethane (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form Solid
pka 15.07±0.50(Predicted)
color Off-White
InChI InChI=1S/C14H23N3O2/c1-5-17(6-2)8-7-15-14(19)13-10(3)12(9-18)16-11(13)4/h9,16H,5-8H2,1-4H3,(H,15,19)
InChIKey BRZYBFNUINXZMJ-UHFFFAOYSA-N
SMILES N1C(C=O)=C(C)C(C(NCCN(CC)CC)=O)=C1C
FDA UNII 8TS2JL9Q75

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Health Hazard (GHS08)Environment (GHS09)Flame (GHS02)
GHS07,GHS08,GHS09,GHS02
Signal word  Danger
Hazard statements  H315-H319-H335-H336-H304-H410-H225
Precautionary statements  P501-P261-P273-P240-P210-P233-P243-P241-P242-P271-P264-P280-P370+P378-P391-P331-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P301+P310-P304+P340+P312-P403+P233-P403+P235-P405
HS Code  2933998090

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide price More Price(65)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-D473853-5G N-[2-(Diethylamino)ethyl]-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide 356068-86-5 5g $135 2026-06-03 Buy
TRC TRC-D473853-250MG N-[2-(Diethylamino)ethyl]-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide 356068-86-5 250mg $70 2026-06-03 Buy
TRC TRC-D473853-1G N-[2-(Diethylamino)ethyl]-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide 356068-86-5 1g $91 2026-06-03 Buy
Biosynth FD151493 N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide 356068-86-5 5g $900 2026-06-04 Buy
Biosynth FD151493 N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide 356068-86-5 50g $900 2026-06-04 Buy
Product number Packaging Price Buy
TRC-D473853-5G 5g $135 Buy
TRC-D473853-250MG 250mg $70 Buy
TRC-D473853-1G 1g $91 Buy
FD151493 5g $900 Buy
FD151493 50g $900 Buy

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide Chemical Properties, Uses, Production

Uses

N-[2-(Diethylamino)ethyl]-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide is used in the preparation of (pyrrolylmethylidene)indolinones as tyrosine kinase inhibitors.

Synthesis

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

253870-02-9

N,N-DIETHYLHYDRAZINE

616-40-0

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

356068-86-5

To a three-necked flask fitted with a thermometer was added 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (3, 5.50 g, 32.7 mmol) and anhydrous DMF (13.1 mL), and cooled in an ice-salt bath to 0°C. Under stirring, a dichloromethane (78.4 mmol) solution of dicyclohexylcarbodiimide (DCC, 10.13 g, 49.0 mmol) was slowly added dropwise. mL) solution, keeping the reaction temperature between 0-2°C. Subsequently, 4-dimethylaminopyridine (DMAP, 1.65 g) and N1,N1-diethylethane-1,2-diamine (4, 5.03 mL, 35.9 mmol) were added and reacted at room temperature. The reaction progression was monitored by TLC (eluent: chloroform/methanol, v/v = 5:1). 59 h later, the reaction mixture was filtered, water was added to the filtrate, and extracted with dichloromethane (15 mL × 3). The organic layers were combined, washed with saturated brine (65.7 mL) and dried over anhydrous sodium sulfate. The filtrate was concentrated to give a solid, which was dissolved in a small amount of dichloromethane (5.0 mL). The resulting organic phase was washed with 5.0% aqueous citric acid (330 mL × 3) until TLC showed no product in the organic layer. The aqueous phase was alkalized to pH 8 with saturated aqueous sodium hydroxide and a large amount of aqueous sodium bicarbonate and extracted with dichloromethane (330 mL × 3). The organic layers were combined and concentrated to give a brown-red oily liquid. Further purification by column chromatography (eluent: petroleum ether/ethyl acetate, v/v = 3:1 to 1:1) afforded N-(2-(diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide (10, 8.11 g, 86.3%) as a yellowish solid with a melting point of 153-154 °C (literature value 177-181 °C). Yield 42.5%. rf = 0.60 (eluent: chloroform/methanol, v/v = 5:1). 1H NMR (400 MHz, DMSO-d6) δ: 11.85 (s, 1H, NH), 9.54 (s, 1H, CHO), 7.36-7.38 (t, 1H, CONH), 3.24-3.29 (m, 2H, NHCH2) , 2.50-2.56 (m, 6H, 3 × N-CH2), 2.32 (s, 3H, 4-CH3), 2.37 (s, 3H, 2-CH3), 0.95-0.99 (t, 6H, 2 × CH3).

References

[1] Research on Chemical Intermediates, 2015, vol. 41, # 11, p. 8941 - 8954

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide Preparation Products And Raw materials

Raw materials

5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid N,N-Diethylethylenediamine N,N-Diethylhydrazine N,N-Dimethylformamide Dicyclohexylcarbodiimide
4-Dimethylaminopyridine Dichloromethane

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Preparation Products

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide Suppliers

Global Suppliers ( 225)
Supplier Tel Email Country ProdList Advantage
Hangzhou Chemtrue Bio-Tech Co.,Ltd. 19967494293 sales@chemtrue-bio.com China 303 58
Aurisco Pharmaceutical (Tianjin) Inc. 022-59885855 China 96 58
PharmaBlock Sciences (Nanjing),Inc. 025-86918202 4000255188 sales@pharmablock.com China 5000 55
Suzhou haiyu Biochem Industrial Co., LTD 512-68097639 18013585858 744942877@qq.com China 915 62
Beijing Lunarsun Pharmaceutical Co.,LTD. 86-10-64911848-8020.8010 sales@lunarsun.com.cn China 95 60
Jinan Trio PharmaTech Co., Ltd. 0531-88811783 sales@trio-pharmatech.com China 1856 62
Syntechem Co.,Ltd info@syntechem.com China 12973 57
ZhengZhou HuaWen Chemical Co.Ltd 0370-2785118 17550508557 675141927@qq.com China 3201 55
T&W GROUP 021-61551611 13296011611 contact@trustwe.com China 9884 58
Suzhou Sibian Chemical Technology Co.,Ltd. 0512-65617459 18915409046 sales@sibian-chem.com China 1917 55
Supplier Advantage
Hangzhou Chemtrue Bio-Tech Co.,Ltd. 58
Aurisco Pharmaceutical (Tianjin) Inc. 58
PharmaBlock Sciences (Nanjing),Inc. 55
Suzhou haiyu Biochem Industrial Co., LTD 62
Beijing Lunarsun Pharmaceutical Co.,LTD. 60
Jinan Trio PharmaTech Co., Ltd. 62
Syntechem Co.,Ltd 57
ZhengZhou HuaWen Chemical Co.Ltd 55
T&W GROUP 58
Suzhou Sibian Chemical Technology Co.,Ltd. 55

View Latest Price from N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide pictures 2026-09-02 N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5
 $5.00 1KG 98% Henan Fengda Chemical Co., Ltd
N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide pictures 2025-06-27 N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5
 $10.00-30.00 50KG 99% 500000kg Hebei Chuanghai Biotechnology Co., Ltd
N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide pictures 2025-06-20 N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide
356068-86-5
 1kg 0.99 20 tons Hebei Yanxi Chemical Co., Ltd.

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide Spectrum

N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide(356068-86-5)1HNMR

356068-86-5 (N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide) Related Search:

N-ethyl-pyrrolidone N-(2-Hydroxyethyl)-2-pyrrolidone N-[2-(DiethylaMino)ethyl]-2,4-diMethyl-1H-pyrrole-3-CarboxaMide De-5-fluoro 4-FluorochidaMide Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate
5-Fluoro-2-oxindole Pyrrole-2,4-dicarboxaldehyde, 3,5-dimethyl- (6CI,7CI,8CI) Sunitinib iMpurity Sunitinib Malate Ethyl 2,4-dimethyl-1H-pyrrole-3-carboxylate
N-Desethyl Sunitinib 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (Z)-5-((5-fluoro-2-oxoindolin-3-ylidene)Methyl)-2,4-diMethyl-1H-pyrrole-3-carboxaMide Sunitinib Impurity 7 Sunitinib Impurity 2
Sunitinib Impurity 9 Sunitinib Impurity 1 2,4-Dimethyl pyrrol-3-carbaldehyde

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N-(2-(Diethylamino)ethyl)-5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid N-(2-diethylaminoethyl)amide N-[2-(Diethylamino)ethyl 3-{[2-(Diethylamino)ethyl]carbamoyl}-2,4-dimethyl-5-formyl-1H-pyrrole N-[2-(Diethylamino)ethyl]-2,4-dimethyl-5-formyl-1H-pyrrole-3-carboxamide N-[2-(DIETHYLAMINO)ETHYL]-5-FORMYL-2,4-DIMETHYL-1H 3-{[2-(Diethylamino)ethyl]carbamoyl}-2,4-dimethyl-5-formyl-1H-pyrrole, 4-{[2-(Diethylamino)ethyl]carbamoyl}-2,4-dimethyl-1H-pyrrole-2-carboxaldehyde sunitinib PI-5 Sunitinib Malate 2 -5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxamide N-(2-(Diethylamino) 1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-formyl-2,4-dimethyl- Sunitinib Impurity 3 Sunitinib Impurity 50 Sunitinib Aldehyde Impurity N-[2-(Diethylamino)ethyl]-5-formyl- N-[2-(DIETHYLAMMINO)ETHYL]-5-FORMYL-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE 5-Formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-dieth... N-(2-(Diethylamino)ethyl)-5-formyl-2 Sunitinib EP Impurity-C N-(2-(Diethylamino)ethyl)-5-formy1-2,4-dimethyl-1H-pyrrole-3-carboxamide N- (2- (diethylaminoethyl) -5-formyl-2, 4-dimethyl-1h-pyrrolid-3-formamide) 356068-86-5 251356-82-6 56068-86-5 Intermediates 356068-86-5