N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
- CAS No.
- 72926-24-0
- Chemical Name:
- N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
- Synonyms
- K 858;K858;K-858;K858 (Racemic);K858 (Racemic), 10 mM in DMSO;inhibit,Inhibitor,K858 (Racemic),Apoptosis,K-858 (Racemic),Kinesin;N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide;N-(4-acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)a Cetamide;Acetamide, N-(4-acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)-;N-(4-ethylacyl-4，5-dihydro-5-methyl-5-phenyl-1，3，4-thiodiazole-2-yl)acetamide
- CBNumber:
- CB12518940
- Molecular Formula:
- C13H15N3O2S
- Molecular Weight:
- 277.34
- MDL Number:
- MFCD00181155
- MOL File:
- 72926-24-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| K 858 ≥98% (HPLC) | K3644 | 25mg | $292 |
| K 858 ≥98% (HPLC) | K3644 | 5mg | $109 |
| K 858 | K0076 | 25MG | $229 |
| K858 ≥98% | 22112 | 1mg | $36 |
| K858 ≥98% | 22112 | 5mg | $77 |
| More product size | |||
| Melting point | 216-217 °C(Solv: ethanol (64-17-5)) |
|---|---|
| Density | 1.27±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| pka | 8.61±0.40(Predicted) |
| color | white to off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| InChI | 1S/C13H15N3O2S/c1-9(17)14-12-15-16(10(2)18)13(3,19-12)11-7-5-4-6-8-11/h4-8H,1-3H3,(H,14,15,17) |
| InChIKey | JEFVYQYZCAVNTP-UHFFFAOYSA-N |
| SMILES | CC(=O)NC1=NN(C(C)=O)C(C)(S1)c2ccccc2 |
| FDA UNII | ZA4OIM722G |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 1 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide price More Price(101)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | K3644 | K 858 ≥98% (HPLC) | 72926-24-0 | 25mg | $292 | 2026-04-30 | Buy |
| Sigma-Aldrich | K3644 | K 858 ≥98% (HPLC) | 72926-24-0 | 5mg | $109 | 2022-05-15 | Buy |
| TCI Chemical | K0076 | K 858 | 72926-24-0 | 25MG | $229 | 2026-04-30 | Buy |
| Cayman Chemical | 22112 | K858 ≥98% | 72926-24-0 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 22112 | K858 ≥98% | 72926-24-0 | 5mg | $77 | 2026-04-30 | Buy |
N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide Chemical Properties,Uses,Production
Description
K858 (72926-24-0) is a selective mitotic kinesin Eg5 inhibitor (IC50 = 1.3 μM) which acts in an ATP-noncompetitive manner.1,2It is at least 150-fold more selective for Eg5 than other members of the kinesin superfamily. K-858 blocks centrosome separation, activates the spindle checkpoint and induces mitotic arrest accompanied by the formation of monopolar spindles. Displays no effect on microtubule polymerization. Selectively displays antiproliferative effects via induction of mitotic cell death in cancer cells over nontransformed cells.1
Uses
K 858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor.
Definition
ChEBI: N-(4-acetyl-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide is a member of benzenes.
in vivo
K858 (50, 150 mg/kg, p.o.) shows antitumor activity in an A2780 ovarian cancer xenograft model, also inhibits tumor grwoth in a HCT116 colon cancer xenograft model via 100 mg/kg twice a day orally for 5 days. K858 (100 mg/kg, p.o., qd ×5) displays no neurotoxic side effects in mice[1].
IC 50
Eg5: 1.3 μM (IC50)
References
[1] RYUICHIRO NAKAI. K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells.[J]. Cancer research, 2009, 69 9: 3901-3909. DOI:10.1158/0008-5472.can-08-4373
[2] ROSE-LAURE INDORATO . STLC-resistant cell lines as tools to classify chemically divergent Eg5 targeting agents according to their mode of action and target specificity[J]. Biochemical pharmacology, 2013, 86 10: Pages 1441-1451. DOI:10.1016/j.bcp.2013.09.003
N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29792 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5742 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471; | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39039 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 9949 | 58 |
View Lastest Price from N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-22 | K858 (Racemic)
72926-24-0
|
$30.00-98.00 | 99.24% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-12-24 | N-(4-Acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide
72926-24-0
|
$1.00 | 1KG | Min98% HPLC | Career Henan Chemical Co |
-
- K858 (Racemic)
72926-24-0
- $30.00-98.00
- 99.24%
- TargetMol Chemicals Inc.
-
- N-(4-Acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide
72926-24-0
- $1.00
- Min98% HPLC
- Career Henan Chemical Co
