N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
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- $12 - $1600
- Product name: N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
- CAS: 72926-24-0
- MF: C13H15N3O2S
- MW: 277.34
- EINECS:
- MDL Number:MFCD00181155
- Synonyms:K 858;N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide;N-(4-acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)a Cetamide;K858;K-858;K858 (Racemic);Acetamide, N-(4-acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)-;inhibit,Inhibitor,K858 (Racemic),Apoptosis,K-858 (Racemic),Kinesin;K858 (Racemic), 10 mM in DMSO
101 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 10
- 1mg
- 5mg
- 10mg
- 25.00mg
- 25mg
- 50
- 50mg
- 50.00mg
- 100MG
- 100.00mg
- 250mg
- 0.5g
- 1g
- 2.5G
- 10mM*1mLinDMSO(Solid+Solvent)
- 5G
- 10mM*1mLinDMSO
- 10mM*1mLinDMSO(Solution)
- Manufactureraablocks
- Product numberAA00FBZU
- Product descriptionN-(4-Acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide 98%
- Packaging1mg
- Price$12
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FBZU
- Product descriptionN-(4-Acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide 98%
- Packaging5mg
- Price$22
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FBZU
- Product descriptionN-(4-Acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide 98%
- Packaging10mg
- Price$30
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FBZU
- Product descriptionN-(4-Acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide 98%
- Packaging25mg
- Price$47
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FBZU
- Product descriptionN-(4-Acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide 98%
- Packaging50mg
- Price$79
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberP51283
- Product descriptionK 858 95%
- Packaging25MG
- Price$95
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberP51283
- Product descriptionK 858 95%
- Packaging100MG
- Price$250
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number9996AF
- Product descriptionN-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
- Packaging10mg
- Price$184
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number9996AF
- Product descriptionN-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
- Packaging5mg
- Price$124
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number9996AF
- Product descriptionN-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide
- Packaging100mg
- Price$945
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA394288
- Product descriptionK858 (Racemic) 98%
- Packaging1g
- Price$690
- Updated2026-06-05
- Buy
- ManufacturerAmbeed
- Product numberA394288
- Product descriptionK 858 98+%
- Packaging25mg
- Price$248
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA394288
- Product descriptionK 858 98+%
- Packaging50mg
- Price$346
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA394288
- Product descriptionK 858 98+%
- Packaging100mg
- Price$519
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA394288
- Product descriptionK 858 98+%
- Packaging5mg
- Price$111
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA394288
- Product descriptionK858 (Racemic) 98%
- Packaging100mg
- Price$152
- Updated2026-06-05
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00FBZU | N-(4-Acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide 98% | 1mg | $12 | 2026-05-28 | Buy |
| aablocks | AA00FBZU | N-(4-Acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide 98% | 5mg | $22 | 2026-05-28 | Buy |
| aablocks | AA00FBZU | N-(4-Acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide 98% | 10mg | $30 | 2026-05-28 | Buy |
| aablocks | AA00FBZU | N-(4-Acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide 98% | 25mg | $47 | 2026-05-28 | Buy |
| aablocks | AA00FBZU | N-(4-Acetyl-5-methyl-5-phenyl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide 98% | 50mg | $79 | 2026-05-28 | Buy |
| ACHEMBLOCK | P51283 | K 858 95% | 25MG | $95 | 2026-05-27 | Buy |
| ACHEMBLOCK | P51283 | K 858 95% | 100MG | $250 | 2026-05-27 | Buy |
| AK Scientific | 9996AF | N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide | 10mg | $184 | 2021-12-16 | Buy |
| AK Scientific | 9996AF | N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide | 5mg | $124 | 2021-12-16 | Buy |
| AK Scientific | 9996AF | N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)acetamide | 100mg | $945 | 2021-12-16 | Buy |
| Ambeed | A394288 | K858 (Racemic) 98% | 1g | $690 | 2026-06-05 | Buy |
| Ambeed | A394288 | K 858 98+% | 25mg | $248 | 2021-12-16 | Buy |
| Ambeed | A394288 | K 858 98+% | 50mg | $346 | 2021-12-16 | Buy |
| Ambeed | A394288 | K 858 98+% | 100mg | $519 | 2021-12-16 | Buy |
| Ambeed | A394288 | K 858 98+% | 5mg | $111 | 2021-12-16 | Buy |
| Ambeed | A394288 | K858 (Racemic) 98% | 100mg | $152 | 2026-06-05 | Buy |
Properties
Melting point :216-217 °C(Solv: ethanol (64-17-5))
Density :1.27±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :DMSO: ≥20mg/mL
form :powder
pka :8.61±0.40(Predicted)
color :white to off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChI :1S/C13H15N3O2S/c1-9(17)14-12-15-16(10(2)18)13(3,19-12)11-7-5-4-6-8-11/h4-8H,1-3H3,(H,14,15,17)
InChIKey :JEFVYQYZCAVNTP-UHFFFAOYSA-N
SMILES :CC(=O)NC1=NN(C(C)=O)C(C)(S1)c2ccccc2
Density :1.27±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :DMSO: ≥20mg/mL
form :powder
pka :8.61±0.40(Predicted)
color :white to off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChI :1S/C13H15N3O2S/c1-9(17)14-12-15-16(10(2)18)13(3,19-12)11-7-5-4-6-8-11/h4-8H,1-3H3,(H,14,15,17)
InChIKey :JEFVYQYZCAVNTP-UHFFFAOYSA-N
SMILES :CC(=O)NC1=NN(C(C)=O)C(C)(S1)c2ccccc2
Safety Information
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Description
K858 (72926-24-0) is a selective mitotic kinesin Eg5 inhibitor (IC50 = 1.3 μM) which acts in an ATP-noncompetitive manner.1,2It is at least 150-fold more selective for Eg5 than other members of the kinesin superfamily. K-858 blocks centrosome separation, activates the spindle checkpoint and induces mitotic arrest accompanied by the formation of monopolar spindles. Displays no effect on microtubule polymerization. Selectively displays antiproliferative effects via induction of mitotic cell death in cancer cells over nontransformed cells.1Related product price
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Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
Zibo Hangyu Biotechnology Development Co., Ltd
