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S-Trityl-L-cysteine

S-Trityl-L-cysteine structure

CAS No.: 2799-07-7

Chemical Name:: S-Trityl-L-cysteine

Synonyms: H-CYS(TRT)-OH;Dimethyl 5-bromopyridine-2,3-dicarboxylate;L-Cys(Trt)-OH;H-L-Cys(Trt)-OH;S-Tritylcysteine;H-Cys(Trt)-OH (Cys of Animal Origin);NSC 83265;EG5 INHIBITOR II;CYSTEINE(TRT)-OH;TRITYL-L-CYSTEINE

CBNumber:: CB7164332

Molecular Formula:: C22H21NO2S

Molecular Weight:: 363.47

MDL Number:: MFCD00002611

MOL File:: 2799-07-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-14 16:49:18

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S-Trityl-L-cysteine Properties

Melting point	182-183 °C (dec.)(lit.)
Boiling point	524.7±50.0 °C(Predicted)
Density	1.1342 (rough estimate)
refractive index	111 ° (C=0.8, 0.04mol Ethanolic HCl)
storage temp.	Sealed in dry,Room Temperature
solubility	Soluble in DMSO (up to 20 mg/ml).
form	White to off-white solid.
pka	2.22±0.10(Predicted)
color	White or off-white
optical activity	[α]25/D +115°, c = 0.8 in 0.04 M ethanolic HCl
BRN	2339626
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
Major Application	peptide synthesis
InChI	InChI=1S/C22H21NO2S/c23-20(21(24)25)16-26-22(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,20H,16,23H2,(H,24,25)/t20-/m0/s1
InChIKey	DLMYFMLKORXJPO-FQEVSTJZSA-N
SMILES	C(O)(=O)[C@H](CSC(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1)N
CAS DataBase Reference	2799-07-7(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312+P330-P501-P301+P312a-P330-P501a

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

Safety Statements

22-24/25

WGK Germany

RTECS

AY7710000

HS Code

29309090

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral

Toxicity

dog,LDLo,intravenous,150mg/kg (150mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY),National Technical Information Service. Vol. PB81-109993,

NFPA 704

	1
1		0

S-Trityl-L-cysteine price More Price(93)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	164739	(+)-S-Trityl-L-cysteine 97%	2799-07-7	5g	$216	2026-04-30	Buy
TCI Chemical	T2522	S-Trityl-L-cysteine >95.0%(T)	2799-07-7	5g	$53	2026-04-30	Buy
Cayman Chemical	23236	S-trityl-L-Cysteine ≥98%	2799-07-7	1g	$28	2026-04-30	Buy
Cayman Chemical	23236	S-trityl-L-Cysteine ≥98%	2799-07-7	5g	$85	2026-04-30	Buy
Cayman Chemical	23236	S-trityl-L-Cysteine ≥98%	2799-07-7	10g	$154	2026-04-30	Buy

Product number	Packaging	Price	Buy
164739	5g	$216	Buy
T2522	5g	$53	Buy
23236	1g	$28	Buy
23236	5g	$85	Buy
23236	10g	$154	Buy

S-Trityl-L-cysteine Chemical Properties, Uses, Production

Description

S-Trityl-cysteine (2799-07-7) is a cell permeable inhibitor of mitotic kinesin Eg5 (IC50 for inhibition of basal ATPase activity = 1 μM; IC50 for inhibition of microtubule-activated ATPase activity = 140 nM). Mean growth concentration (GI50) of 1.31 μM for a panel of 60 different tumor cell lines.

Chemical Properties

almost white to light yellow granular powder

Uses

A protected cysteine for peptide synthesis. S-Trityl-L-cysteine (STLC) is a tight-binding inhibitor of Eg5 that prevents mitotic progression. It has proven antitumor activity as shown in the NCI 60 tumor cell line screen.

Uses

(+)-S-Trityl-L-cysteine, a non-natural, sulfur-containing amino acid is commonly used as a reagent in solution phase peptide synthesis (SPPS). It is also used as a metal-binding agent to synthesize substituted ferrocenoyl peptide conjugates using HBTU peptide coupling reagent for the cation-sensing applications solution via peptide-metal interactions.

Definition

ChEBI: (2R)-2-amino-3-[(triphenylmethyl)thio]propanoic acid is a benzenoid aromatic compound.

reaction suitability

reaction type: solution phase peptide synthesis

Biological Activity

Potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, a protein required for establishing and maintaining a bipolar spindle. Inhibits basal ATPase activity (IC 50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC 50 = 140 nM). Induces mitotic arrest in HeLa cells with an IC 50 of 700 nM. Displays antitumor activity.

Synthesis

76-84-6

52-89-1

2799-07-7

Triphenylmethanol (3.3 g, 12.7 mmol) and L-cysteine hydrochloride (2 g, 12.7 mmol) were reacted in 25 mL of trifluoroacetic acid (TFA). The mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the mixture was cooled to 0 °C, followed by the slow addition of 4 N sodium hydroxide solution and ether (40 mL) to adjust the pH to 4-5. Next, 10% aqueous sodium acetate was added to further adjust the pH to 5-6. The precipitate precipitated from the reaction mixture was collected by filtration, washed with fresh ether, and dried to afford S-trityl-L-cysteine (5 g, 98% yield). The structure of the product was confirmed by 1H NMR (DMSO-d6): δ 2.35-2.61 (m, 2H, CH2), 2.85-2.98 (m, 1H, CH), 7.2-7.45 (m, 15H, triphenylmethyl-L-H).MALDI-TOF MS analysis showed m/z 364.7 [M + H]+, which is in agreement with the theoretical C22H21NO2S molecular weight (363.47).

storage

Store at +4°C

References

[1] S. DEBONIS. In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities.[J]. Molecular Cancer Therapeutics, 2004, 3 9 1: 1079-1090. DOI:10.1158/1535-7163.1079.3.9
[2] SÉBASTIEN BRIER. Identification of the Protein Binding Region of S-Trityl-l-cysteine, a New Potent Inhibitor of the Mitotic Kinesin Eg5†[J]. Biochemistry Biochemistry, 2004, 43 41: 13072-13082. DOI:10.1021/bi049264e
[3] DIMITRIOS A SKOUFIAS. S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.[J]. The Journal of Biological Chemistry, 2006, 281 26: 17559-17569. DOI:10.1074/jbc.m511735200

S-Trityl-L-cysteine Preparation Products And Raw materials

Raw materials

Triphenylmethanol L-Cysteine monohydrochloride Triphenylmethyl Chloride L-Cysteine Sodium acetate

Water Diethyl ether Sodium hydroxide

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Preparation Products

S-Trityl-L-cysteine Suppliers

Global Suppliers ( 295)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11592	64
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
GL Biochem (Shanghai) Ltd	64
Capot Chemical Co., Ltd	66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64
VDM Biochemicals	64

View Latest Price from S-Trityl-L-cysteine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-14	S-trityl-L-Cysteine 2799-07-7	$31.00-81.00		97.08%	10g	TargetMol Chemicals Inc.
2021-07-02	(+)-S-Trityl-L-cysteine 97% 2799-07-7	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06	S-Trityl-L-cysteine 2799-07-7	$1.00	1KG	99%	20kg	Career Henan Chemical Co

S-trityl-L-Cysteine
2799-07-7
$31.00-81.00
97.08%
TargetMol Chemicals Inc.

(+)-S-Trityl-L-cysteine 97%
2799-07-7
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

S-Trityl-L-cysteine
2799-07-7
$1.00
99%
Career Henan Chemical Co

S-Trityl-L-cysteine Spectrum

S-Trityl-L-cysteine(2799-07-7)MS S-Trityl-L-cysteine(2799-07-7)¹HNMR S-Trityl-L-cysteine(2799-07-7)¹³CNMR S-Trityl-L-cysteine(2799-07-7)IR1 S-Trityl-L-cysteine(2799-07-7)IR2 S-Trityl-L-cysteine(2799-07-7)Raman

2799-07-7 (S-Trityl-L-cysteine) Related Search:

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3-(tritylthio)-l-alanin 3-tritylthio-l-alanine s-(triphenylmethyl)-l-cystein H-Cys(Trt)-OH (Cys of Animal Origin) H-Cys(Trt)-OH (Cys of Non Animal Origin) S-Trityl-L-cysteine≥ 98% (HPLC) CYSTEINE(TRT)-OH EG5 INHIBITOR II NSC 83265 S-(TRIPHENYLMETHYL)-L-CYSTEINE (+)-S-TRITYL-L-CYSTEINE (2R)-2-ammonio-3-[(triphenylmethyl)thio]propanoate (2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoic acid S-TRITYL-L-CYSTEINE TRITYL-L-CYSTEINE S-TRITYL-L-CYSTEINE CRYSTALLINE (+)-S-TRITYL-L-CYSTEINE 97% L-Cysteine, -3,3-D2-S-Trityl (R)-2-Amino-3-(tritylthio)propionic acid (R)-S-Tritylcysteine S-Trityl-(R)-cycteine S-Tritylcysteine S-TRITYL-L-CYSTEINE extrapure (2R)-2-AMino-3-[(triphenylMethyl)thio]propanoic Acid S-Trityl-(R)-cysteine Tritylthioalanine S-Trityl-L-cysteine,97% (R)-2-AMino-3-tritylsulfanyl-propionic acid L-CYSTEINE, S-TRITYL L-Cysteine, S-(triphenylmethyl)- S-Trityl-L-cysteine USP/EP/BP S-Tritylcysteine,Kinesin,StritylLCysteine,Apoptosis,328542,inhibit,cell cycle arrest,Inhibitor,NSC 83265,antitumor activities,NSC-83265,ATPase activity,kinesin Eg5,NSC83265,S trityl L Cysteine Tritylthioalanine (H-Cys(Trt)-OH) Impurity IIa-2 (S-triphenylmethylL-cysteine) S-Trityl-cysteine, kinesin Eg5 inhibitor S-trityl-L-Cysteine, 10 mM in DMSO (+)-S-Trityl-L-cysteine S-Trityl-L-cysteine - animal origin (2R)-2-azaniumyl-3-tritylsulfanylpropanoate Dimethyl 5-bromopyridine-2,3-dicarboxylate H-CYS(TRT)-OH H-L-Cys(Trt)-OH L-Cys(Trt)-OH 2799-07-7 2799-7-7 279-07-7 2799-07-07 7/7/2799 2799/7/7 328542 C6H53CSCD2CHNH2COOH C6H53CSCH2CHNH2CO2H Specialty Synthesis Peptide Synthesis Cysteine/Cystine CARBOXYLIC ACID Amino Acid Derivatives Cell Cycle Regulation