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3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester

CAS No.
161833-42-7
Chemical Name:
3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester
Synonyms
Methyl 3-amino-4-bromothiophene-2-formate;3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester;3-Amino-4-bromothiophen-2-carboxylic acid methyl ester;3-Amino-4-bromo-2-thiophenecarboxylic acid methyl ester;2-Thiophenecarboxylic acid, 3-amino-4-bromo-, methyl ester;3-amino-4-bromo-2-Thiophenecarboxylic acid methyl ester (9CI ACI);2-Thiophenecarboxylic acid, 3-amino-4-bromo-, methyl ester (9CI, ACI)
CBNumber:
CB12550461
Molecular Formula:
C6H6BrNO2S
Molecular Weight:
236.09
MDL Number:
MFCD09038329
MOL File:
161833-42-7.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:46

3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester Properties

Boiling point 333.6±37.0 °C(Predicted)
Density 1.745±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
pka -0.20±0.10(Predicted)
Appearance White to off-white Solid
InChI InChI=1S/C6H6BrNO2S/c1-10-6(9)5-4(8)3(7)2-11-5/h2H,8H2,1H3
InChIKey LWSWLXPUUCBUPI-UHFFFAOYSA-N
SMILES C1(C(OC)=O)SC=C(Br)C=1N

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H315-H335
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC M286695 Methyl3-Amino-4-bromothiophene-2-carboxylate 161833-42-7 50mg $60 2021-12-16 Buy
Ark Pharm P000508829 Methyl 3-amino-4-bromothiophene-2-carboxylate 95+% 161833-42-7 100mg $16 2021-12-16 Buy
Ark Pharm P000508829 Methyl 3-amino-4-bromothiophene-2-carboxylate 95+% 161833-42-7 250mg $25 2021-12-16 Buy
Ark Pharm P000508829 Methyl 3-amino-4-bromothiophene-2-carboxylate 95+% 161833-42-7 5g $172 2021-12-16 Buy
Ark Pharm P000508829 Methyl 3-amino-4-bromothiophene-2-carboxylate 95+% 161833-42-7 10g $342 2021-12-16 Buy
Product number Packaging Price Buy
M286695 50mg $60 Buy
P000508829 100mg $16 Buy
P000508829 250mg $25 Buy
P000508829 5g $172 Buy
P000508829 10g $342 Buy

3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester Chemical Properties,Uses,Production

Synthesis

Methyl 3-amino-2-thiophenecarboxylate

22288-78-4

3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester

161833-42-7

Example 2: Synthesis of 3-[(dimethylamino)diazenyl]-4-bromothiophene-2-carboxamide (Compound 2) Step a: Synthesis of methyl 3-amino-4-bromothiophene-2-carboxylate To a solution of methyl 3-aminothiophene-2-carboxylate (1 g, 6.36 mmol) in acetic acid (10 mL), a solution of bromine (0.32 mL, 6.36 mmol) in acetic acid (1 mL) was slowly added, and the addition process lasted for 5 min, and the reaction was carried out at room temperature. After addition, the reaction mixture was stirred at the same temperature for 16 hours. After completion of the reaction, the mixture was poured into ice-cold water and extracted with chloroform (3 x 100 mL). The organic layers were combined, washed sequentially with water and brine and dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography with the eluent petroleum ether-ethyl acetate (95:5, v/v) to afford the target product methyl 3-amino-4-bromothiophene-2-carboxylate as a light yellow solid (0.5 g, 33% yield) with a melting point of 58-60°C. The residue was extracted with water and sodium sulfate. 1H NMR (400 MHz, CDCl3): δ 7.29 (s, 1H), 5.63 (br s, 2H), 3.85 (s, 3H).

References

[1] Bulletin of the Korean Chemical Society, 2016, vol. 37, # 9, p. 1406 - 1414
[2] Patent: WO2010/29577, 2010, A2. Location in patent: Page/Page column 28-29
[3] Patent: US2010/68178, 2010, A1. Location in patent: Page/Page column 12
[4] Patent: CN106167497, 2016, A. Location in patent: Paragraph 0162; 0163; 0164
[5] Patent: EP2708540, 2014, A1. Location in patent: Paragraph 0137

22288-78-4
161833-42-7
Synthesis of 3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester from Methyl 3-amino-2-thiophenecarboxylate

3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 91)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+8613336195806 sales@capot.com China 29734 60
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co
+86-0371-86658258 +8613203830695 sales@coreychem.com China 29852 58
Accela ChemBio Inc.
+1-858-6993322 info@accelachem.com United States 21193 58
Fuxin Pharmaceutical
+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 10035 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Neostar United (Changzhou) Industrial Co., Ltd.
+86-0519-85551759 +8613506123987 marketing1@neostarunited.com China 8826 58
Shanghai Rlavie Technology Co ltd
+86-021-67759270 +8617717059219 sales@rlavie.com China 1030 58
CD Chemical Group Limited
+8615986615575 info@codchem.com China 20342 58
Labnetwork lnc.
+86-27-50766799 +8618062016861 contact@labnetwork.com China 19987 58

View Lastest Price from 3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester pictures 2022-04-22 3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester
161833-42-7
US $0.00-0.00 / kg 0.0001kg 98%min 100kgs/month Shanghai Rlavie Technology Co ltd
3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester pictures 2019-07-12 3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester
161833-42-7
US $1.00 / KG 1KG 99% 100kg Career Henan Chemical Co

3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester Spectrum

161833-42-7(3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester)Related Search:

3-Amino-4-bromo-2-thiophenecarboxylic acid methyl ester 3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester 2-Thiophenecarboxylic acid, 3-amino-4-bromo-, methyl ester 2-Thiophenecarboxylic acid, 3-amino-4-bromo-, methyl ester (9CI, ACI) 3-amino-4-bromo-2-Thiophenecarboxylic acid methyl ester (9CI ACI) 3-Amino-4-bromothiophen-2-carboxylic acid methyl ester Methyl 3-amino-4-bromothiophene-2-formate 161833-42-7