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Methyl 3-amino-2-thiophenecarboxylate

Methyl 3-amino-2-thiophenecarboxylate Structure
Methyl 3-amino-2-thiophenecarboxylate structure
CAS No.
22288-78-4
Chemical Name:
Methyl 3-amino-2-thiophenecarboxylate
Synonyms
METHYL 3-AMINOTHIOPHENE-2-CARBOXYLATE;3-aminothiophene-2-carboxylate;M3AT2C;AKOS 92421;ina-5545-2;Methyl3-am;AKOS B020093;Methyl 3-amino-2-;3-Amino-2-thenoate;RARECHEM AM UC 0123
CBNumber:
CB5123399
Molecular Formula:
C6H7NO2S
Molecular Weight:
157.19
MDL Number:
MFCD00009765
MOL File:
22288-78-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:15:01
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Methyl 3-amino-2-thiophenecarboxylate Properties

Melting point 62-64 °C (lit.)
Boiling point 100-102 °C/0.1 mmHg (lit.)
Density 1.274 (estimate)
refractive index 1.5500 (estimate)
Flash point 100-102°C/0.1mm
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Soluble in alcohol, toluene, xylene and other solvents
form Fine Crystalline Powder
pka 1.86±0.10(Predicted)
color Beige to beige-brown
Water Solubility Slightly soluble in water.
BRN 1365614
InChI InChI=1S/C6H7NO2S/c1-9-6(8)5-4(7)2-3-10-5/h2-3H,7H2,1H3
InChIKey TWEQNZZOOFKOER-UHFFFAOYSA-N
SMILES C1(C(OC)=O)SC=CC=1N
CAS DataBase Reference 22288-78-4(CAS DataBase Reference)
FDA UNII E7S8G23AHX
EPA Substance Registry System 2-Thiophenecarboxylic acid, 3-amino-, methyl ester (22288-78-4)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39-36/37/39-22
WGK Germany  3
RTECS  XM8347500
TSCA  TSCA listed
HazardClass  IRRITANT
HS Code  29349990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

Methyl 3-amino-2-thiophenecarboxylate price More Price(76)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 232904 Methyl 3-amino-2-thiophenecarboxylate 99% 22288-78-4 50g $233 2026-04-30 Buy
Sigma-Aldrich 232904 Methyl 3-amino-2-thiophenecarboxylate 99% 22288-78-4 10g $43.15 2025-07-31 Buy
TCI Chemical A1039 Methyl 3-Amino-2-thiophenecarboxylate >98.0%(GC)(T) 22288-78-4 25g $46 2026-04-30 Buy
TCI Chemical A1039 Methyl 3-Amino-2-thiophenecarboxylate >98.0%(GC)(T) 22288-78-4 100g $142 2026-04-30 Buy
Usbiological 423702 3-Amino-2-methoxycarbonylthiophene 22288-78-4 5g $403 2026-06-03 Buy
Product number Packaging Price Buy
232904 50g $233 Buy
232904 10g $43.15 Buy
A1039 25g $46 Buy
A1039 100g $142 Buy
423702 5g $403 Buy

Methyl 3-amino-2-thiophenecarboxylate Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powder

Uses

Methyl 3-amino-2-thiophenecarboxylate was used in:

  • the synthesis of 4-nitro and 4-aminothienyl ureas
  • total synthesis of quinazolinocarboline alkaloids
  • preparation of thienopyrimidinone analogs

Uses

Methyl 3-amino-2-thiophenecarboxylate is the starting material for synthesising Belvarafenib. Belvarafenib is a small-molecule RAF dimer (type II) inhibitor with potential antitumour activity.

General Description

Methyl 3-amino-2-thiophenecarboxylate reacts with hydrazonoyl chlorides in the presence of triethylamine to yield corresponding N-arylamidrazones.

Safety

Methyl 3-amino-2-thiophenecarboxylate is irritating to the eyes and skin. Contact may cause skin irritation and severe eye irritation. Inhalation may cause respiratory irritation.

Methyl 3-amino-2-thiophenecarboxylate synthesis

2365-48-2
920-37-6
22288-78-4
Synthesis of Methyl 3-amino-2-thiophenecarboxylate from Methyl thioglycolate and 2-Chloroacrylonitrile

Methyl 3-amino-2-thiophenecarboxylate Preparation Products And Raw materials

Raw materials

Methyl thioglycolate 1.3-Dichloropropene Sodium methoxide solution Acrylonitrile 3-Chloroacrylonitrile
3-Aminothiophene-2-carboxylic acid Methyl 3-oxotetrahydrothiophene-2-carboxylate 3-Pyridinecarboxaldehyde 2-Chloroacrylonitrile

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Preparation Products

2,4-Dichlorothieno[3,2-d]pyrimidine 3-(Acetylamino)thiophene-2-carboxylic acid 3-(1H-Pyrrol-1-yl)thiophene-2-carboxylic acid 2,4-Dichlorothieno[3,2-d]pyrimidine Methyl 3-aminosulfonylthiophene-2-carboxylate
Methyl 3-chlorothiophene-2-carboxylate 3-Chlorothiophene-2-carboxamide METHYL 3-[(2-BROMOACETYL)AMINO]THIOPHENE-2-CARBOXYLATE 2,4-DIHYDROXYTHIENO[3,2-D]PYRIMIDINE 3-AMino-4-broMo-thiophene-2-carboxylicacidMethylester
methyl 3-(phenylsulfonamido)thiophene-2-carboxylate 2-Thiophenecarboxylic acid, 3-[[(5-bromo-2,3-dihydro-7-benzofuranyl)sulfonyl]amino]- 3,8-Diaza-5-methylene-6,12-dithiatricyclo[7.3.0.0(3,7)]dodeca-1(9),7(8),10-trien-2-one Methyl 3-(benzoylamino)-2-thiophenecarboxylate

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Methyl 3-amino-2-thiophenecarboxylate Suppliers

Global( 477)Suppliers
Supplier Tel Email Country ProdList Advantage
Weifang QianJin Fine Chemical Co., Ltd. 18753684562 1577399715@qq.COM China 1772 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
Weifang QianJin Fine Chemical Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
future industrial shanghai co., ltd 65
Alfa Aesar 84
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61

View Lastest Price from Methyl 3-amino-2-thiophenecarboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methyl 3-aminothiophene-2-carboxylate pictures 2026-09-11 Methyl 3-aminothiophene-2-carboxylate
22288-78-4
 1KG ≥99% 200mt/year Jinan Finer Chemical Co., Ltd
Methyl 3-amino-2-thiophenecarboxylate pictures 2026-09-11 Methyl 3-amino-2-thiophenecarboxylate
22288-78-4
 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
Methyl 3-amino-2-thiophenecarboxylate pictures 2026-09-02 Methyl 3-amino-2-thiophenecarboxylate
22288-78-4
 $8.00 1KG 99% Henan Fengda Chemical Co., Ltd

Methyl 3-amino-2-thiophenecarboxylate Spectrum

Methyl 3-amino-2-thiophenecarboxylate(22288-78-4)MSMethyl 3-amino-2-thiophenecarboxylate(22288-78-4)1HNMRMethyl 3-amino-2-thiophenecarboxylate(22288-78-4)13CNMRMethyl 3-amino-2-thiophenecarboxylate(22288-78-4)IR1Methyl 3-amino-2-thiophenecarboxylate(22288-78-4)IR2Methyl 3-amino-2-thiophenecarboxylate(22288-78-4)Raman

22288-78-4(Methyl 3-amino-2-thiophenecarboxylate )Related Search:

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AMino-2-thiophenecarboxylate AMino thiophene - 2-3 - carboxylic acid Methyl ester Methyl3-aMino-2-thiophenecarbo RARECHEM AM UC 0123 3-amino-2-thiophenecarboxylicacimethylester ina-5545-2 Methyl3-amino-2-thenoate 3-AMINO-2-METHOXYCARBONYLTHIOPHENE 3-AMINO-2-THIOPHENECARBOXYLIC ACID METHYL ESTER 3-AMINOTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER AKOS 92421 AKOS B020093 ASINEX-REAG BAS 05504796 LABOTEST-BB LT00112337 M3AT2C METHYL 3-AMINO-2-THIOPHENECARBOXYLATE METHYL-3-AMINO-2-THIOPHENE FORMATE METHYL 3-AMINO-2-THIOPHENECARBOXYLATE, 9 9% Methyl 3-aminothiophene-2-carboxylate, 98+% 3-AMINO-2-THIOPHENE METHYLFORMATE Name: 3-Aminothiophene-2-carboxylic acid methyl ester Methyl-3-Aminothiophene-2-Carb 3-amino-2-thiophenecarboxylate 3-aminothiophene-2-carboxyL Methyl 3-amino-2- 3-Aminothiophen-2-carboxylic acid methyl ester Methyl 3-amino-2-thiophenecarboxylate ,98% Methyl3-am Methy1-3-amino-2-thiophene carboxylate 3-Amino-2-thenoate Methyl 3-aminothiophene-2-carboxylate ,95% Methyl 3-amino-2-thi Methyl 3-aMino-2-thiophenecarboxylate, 99% 10GR Methyl 3-aMino-2-thiophenecarboxylate, 99% 50GR 2-Methoxycarbonyl-3-aMino-thiophene 3-aMino-2-carboMethoxythiophene Methyl 3-Amino-2-thiophenecarboxylate > 3-amino-2-carboxylate methyl thiophene Methyl 3-amino-2-thiophenoate Methyl 3-amino-2-thiophenecarboxylate USP/EP/BP Methyl 3-aminothiophene-2-carboxylateQ: What is Methyl 3-aminothiophene-2-carboxylate Q: What is the CAS Number of Methyl 3-aminothiophene-2-carboxylate Q: What is the storage condition of Methyl 3-aminothiophene-2-carboxylate Q: What are the applications of Methyl 3-aminothiophene-2-carboxylate Methyl-3-amino2-thiopene carboxylate Methyl-3-aminothiophen-3-carboxylate 3-aminothiophene-2-carboxylate METHYL 3-AMINOTHIOPHENE-2-CARBOXYLATE 22288-78-4 22288-74-4 C6H7NO2S Heterocyclic Building Blocks Thiophenes Building Blocks API intermediates Thiophenes & Benzothiophenes Pharmaceutical intermediate Sulphur Derivatives INTERMEDIATESOFTENOXICAM Esters Thiophenes & Benzothiophenes