3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester
- CAS No.
- 107818-55-3
- Chemical Name:
- 3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester
- Synonyms
- methyl 3-amino-5-bromothiophene-2-carboxylate;Methyl 3-amino-5-bromo-2-thiophenecarboxylate;3-Amino-5-bromo-thiophene-2-carboxylic acid methyl este;3-Amino-5-bromo-2-thiophenecarboxylic acid methyl ester;5-Bromo-3-aminothiophene-2-carboxylic acid methyl ester;3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester;2-Thiophenecarboxylic acid, 3-amino-5-bromo-, methyl ester;3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester ISO 9001：2015 REACH
- CBNumber:
- CB72525883
- Molecular Formula:
- C6H6BrNO2S
- Molecular Weight:
- 236.09
- MDL Number:
- MFCD12031265
- MOL File:
- 107818-55-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 3-amino-5-bromo-thiophene-2-carboxylate Asreported | 283082 | 1g | $694 |
| Methyl 3-amino-5-bromo-thiophene-2-carboxylate Asreported | 283082 | 2g | $988 |
| Methyl 3-amino-5-bromo-thiophene-2-carboxylate Asreported | 283082 | 5g | $1727 |
| Methyl 3-amino-5-bromo-thiophene-2-carboxylate Asreported | 283082 | 10g | $2608 |
| Methyl 3-amino-5-bromo-thiophene-2-carboxylate Asreported | 283082 | 25g | $3206 |
| Boiling point | 345.5±37.0 °C(Predicted) |
|---|---|
| Density | 1.745±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 1.00±0.10(Predicted) |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C6H6BrNO2S/c1-10-6(9)5-3(8)2-4(7)11-5/h2H,8H2,1H3 |
| InChIKey | RZYLOBBUEWSONL-UHFFFAOYSA-N |
| SMILES | C1(C(OC)=O)SC(Br)=CC=1N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 283082 | Methyl 3-amino-5-bromo-thiophene-2-carboxylate Asreported | 107818-55-3 | 1g | $694 | 2026-06-03 | Buy |
| Usbiological | 283082 | Methyl 3-amino-5-bromo-thiophene-2-carboxylate Asreported | 107818-55-3 | 2g | $988 | 2026-06-03 | Buy |
| Usbiological | 283082 | Methyl 3-amino-5-bromo-thiophene-2-carboxylate Asreported | 107818-55-3 | 5g | $1727 | 2026-06-03 | Buy |
| Usbiological | 283082 | Methyl 3-amino-5-bromo-thiophene-2-carboxylate Asreported | 107818-55-3 | 10g | $2608 | 2026-06-03 | Buy |
| Usbiological | 283082 | Methyl 3-amino-5-bromo-thiophene-2-carboxylate Asreported | 107818-55-3 | 25g | $3206 | 2026-06-03 | Buy |
3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester Chemical Properties,Uses,Production
Synthesis
22288-78-4
107818-55-3
The general procedure for the synthesis of methyl 3-amino-5-bromothiophene-2-carboxylate from methyl 3-amino-2-thiophenecarboxylate is as follows: Example 1: Synthesis of N-(3-aminopropyl)-N-[1-(3-benzyl-6-bromo-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)-2-(dimethylamino)-2-oxoethyl]-4-methylbenzamide (Compound 5 in Table 1) Step 1. Synthesis of methyl 3-amino-5-bromothiophene-2-carboxylate Methyl 3-amino-2-thiophenecarboxylate (1 eq., 25 g) was dissolved in a mixed solvent of 250 ml of dichloromethane and 250 ml of methanol, phenyltrimethylammonium tribromide (3 eq., 180 g) was added followed by calcium carbonate (in appropriate amount). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the calcium carbonate was removed by filtration and the filtrate was concentrated under reduced pressure. To the concentrated filtrate was added water (750 ml) and then extracted with ethyl acetate (1 L). The ethyl acetate layer was washed sequentially with water, sodium thiosulfate solution, saturated sodium bicarbonate solution and saturated sodium chloride solution. The organic layer was dried with magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure to obtain the crude product. The crude product was purified by fast chromatography to afford 21.46 g (57% yield) of methyl 3-amino-5-bromothiophene-2-carboxylate as a light brown oil, the mass spectrum showed MH+ = 238.1.
References
[1] Patent: KR101736387, 2017, B1. Location in patent: Paragraph 0208-0210
[2] Patent: WO2004/111058, 2004, A1. Location in patent: Page/Page column 38
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 9, p. 2535 - 2539
[4] Patent: WO2005/95386, 2005, A1. Location in patent: Page/Page column 110
[5] Patent: EP2540728, 2013, A1
3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester Preparation Products And Raw materials
3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 +86-18019713315 | info@accelachem.com | United States | 21189 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| Unipharm pharmaceutical industry Co., Ltd | 536-8266195 +8613953676784 | lee@unipharm-sd.com | China | 1200 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29096 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24569 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-17732866630 | mina@chuanghaibio.com | China | 18112 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +86-18327326525 | masar@topule.com | China | 8433 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9935 | 58 |
| Protheragen-ING | +86-15618352007 | info@protheragen-ing.com | United States | 3867 | 58 |
View Lastest Price from 3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-11-18 | 3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester
107818-55-3
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2020-04-30 | Methyl 3-amino-5-bromothiophene-2-carboxylate
107818-55-3
|
1KG | 99.0%+ | 800 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2019-09-03 | 3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester
107818-55-3
|
$7.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester
107818-55-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- Methyl 3-amino-5-bromothiophene-2-carboxylate
107818-55-3
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd
-
- 3-Amino-5-bromo-thiophene-2-carboxylic acid methyl ester
107818-55-3
- $7.00
- 99%
- Career Henan Chemical Co
