RETRORSINE
- CAS No.
- 480-54-6
- Chemical Name:
- RETRORSINE
- Synonyms
- Retrosine;RETRORSIN;RETRORSINE;Retrorcine;β-Longilobine;RETRORSINE(AS);BETA-LONGILOBINE;Retrorsine 100 μg/mL in Water;cis-retronecicacidesterofretronecine;16-dione,12,18-dihydroxy-senecionan-1
- CBNumber:
- CB1256406
- Molecular Formula:
- C18H25NO6
- Molecular Weight:
- 351.39
- MDL Number:
- MFCD00870195
- MOL File:
- 480-54-6.mol
| Melting point | 208-211 °C (lit.) |
|---|---|
| alpha | D18 -17.6° (c = 1.99 in ethanol) |
| Boiling point | 485.2°C (rough estimate) |
| Density | 1.32±0.1 g/cm3 (20 ºC 760 Torr) |
| refractive index | 1.5100 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: Slightly soluble: 0.1-1 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml |
| pka | 12.00±0.40(Predicted) |
| form | Solid |
| color | White to off-white |
| Merck | 13,8253 |
| InChI | InChI=1S/C18H25NO6/c1-3-12-8-11(2)18(23,10-20)17(22)24-9-13-4-6-19-7-5-14(15(13)19)25-16(12)21/h3-4,11,14-15,20,23H,5-10H2,1-2H3/b12-3-/t11-,14-,15-,18-/m1/s1 |
| InChIKey | BCJMNZRQJAVDLD-VMOBWIEOSA-N |
| SMILES | N12CC=C3COC(=O)[C@@](O)(CO)[C@H](C)C/C(=C/C)/C(=O)O[C@@]([H])([C@]13[H])CC2 |
| CAS DataBase Reference | 480-54-6 |
| EWG's Food Scores | 1 |
| FDA UNII | XJ86XWL8IY |
| IARC | 3 (Vol. 10, Sup 7) 1987 |
| EPA Substance Registry System | Retrorsine (480-54-6) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300+H310+H330 |
| Precautionary statements | P260-P262-P264-P280-P302+P352+P310-P304+P340+P310 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 22-36/37/39-45 |
| RIDADR | 1544 |
| WGK Germany | 3 |
| RTECS | VH7525000 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| Hazardous Substances Data | 480-54-6(Hazardous Substances Data) |
RETRORSINE price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | R0382 | Retrorsine ≥90% (HPLC) | 480-54-6 | 100mg | $268 | 2025-07-31 | Buy |
| Sigma-Aldrich | R0382 | Retrorsine ≥90% (HPLC) | 480-54-6 | 500mg | $923 | 2025-07-31 | Buy |
| Sigma-Aldrich | PHL89775 | Retrorsine phyproof Reference Substance | 480-54-6 | 10mg | $303 | 2025-07-31 | Buy |
| American Custom Chemicals Corporation | API0009902 | RETRORSINE 95.00% | 480-54-6 | 10MG | $573.3 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 48570 | Retrorsine | 480-54-6 | 10mg | $585 | 2021-12-16 | Buy |
RETRORSINE Chemical Properties,Uses,Production
Uses
Retrorsine-D4 is a labelled analogue of Retrorsine (R279000). Retrorsine is a pyrrolizidine alkaloid that blocks the hepatocyte cell cycle, ultimately affecting hepatocyte proliferative capacity.
Definition
ChEBI: Retrorsine is a macrolide.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Safety Profile
Poison by ingestion, intraperitoneal, and intravenous routes. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. hhtation data reported. When heated to decomposition it emits toxic fumes of NOx.
in vivo
Retrorsine (30 mg/kg; i.p.; twice) impairs liver regeneration in the PBL model not only by an S or G2/M phase block, but also by a block located before the G1/S transition of the cell cycle[4].
| Animal Model: | Male Wistar rats (180±20 g), portal branch ligation (PBL) model[4] |
| Dosage: | 30 mg/kg |
| Administration: | Intraperitoneal injection, twice, separated by 2-week interval |
| Result: | Strongly impaired the liver weight gain, protein and DNA synthesis as well as induction of cell cycle related proteins in the regenerating lobes after PBL. |
References
[1] C.C.J. CULVENOR. Hepato- and pneumotoxicity of pyrrolizidine alkaloids and derivatives in relation to molecular structure[J]. Chemico-Biological Interactions, 1976, 12 3: Pages 299-324. DOI: 10.1016/0009-2797(76)90046-6
[2] M. J. PESTCHANKER O. S G. Pyrrolizidine Alkaloids from Five Senecio Species[J]. Journal of Natural Products , 1986, 49 4: 722-723. DOI: 10.1021/np50046a041
[3] YAN HONG LI. Assessment of pyrrolizidine alkaloid-induced toxicity in an in vitro screening model[J]. Journal of ethnopharmacology, 2013, 150 2: Pages 560-567. DOI: 10.1016/j.jep.2013.09.010
RETRORSINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 954 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32431 | 58 |
| Aktin Chemicals, Inc. | 028-85159085 | info@aktinchem.com | CHINA | 1025 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9629 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9015 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39031 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 10997 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
View Lastest Price from RETRORSINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-17 | Retrorsine
480-54-6
|
US $127.00 / mg | 97.73% | 10g | TargetMol Chemicals Inc. |
-
- Retrorsine
480-54-6
- US $127.00 / mg
- 97.73%
- TargetMol Chemicals Inc.
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