CAY10602
- CAS No.
- 374922-43-7
- Chemical Name:
- CAY10602
- Synonyms
- CAY10602;CAY10602 HCl;CAY10602, >98%;SIRT1 Activator II;CAY10602, 10 mM in DMSO;CAY10602, SIRT1 Activator;SIRT1 Activator II - CAS 374922-43-7 - Calbiochem;Inhibitor,CAY 10602,CAY10602,CAY-10602,inhibit,Sirtuin;1-(4-Fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine;1H-Pyrrolo[2,3-b]quinoxalin-2-amine, 1-(4-fluorophenyl)-3-(phenylsulfonyl)-
- CBNumber:
- CB12590438
- Molecular Formula:
- C22H15FN4O2S
- Molecular Weight:
- 418.44
- MDL Number:
- MFCD02236691
- MOL File:
- 374922-43-7.mol
- MSDS File:
- SDS
| Melting point | 270 °C |
|---|---|
| storage temp. | +2C to +8C |
| solubility | DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml |
| form | Off-white powder |
| color | Light yellow to Amber to Dark green |
| CAS DataBase Reference | 374922-43-7 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
CAY10602 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 566313 | SIRT1 Activator II - CAS 374922-43-7 - Calbiochem The SIRT1 Activator II, also referenced under CAS 374922-43-7, modulates the biological activity of SIRT1. This small molecule/inhibitor is primarily used for Biochemicals applications. |
374922-43-7 | 10mg | $125 | 2024-03-01 | Buy |
| TCI Chemical | F1204 | 1-(4-Fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine | 374922-43-7 | 10MG | $90 | 2024-03-01 | Buy |
| TCI Chemical | F1204 | 1-(4-Fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine | 374922-43-7 | 50MG | $332 | 2024-03-01 | Buy |
| Cayman Chemical | 10009796 | CAY10602 ≥95% | 374922-43-7 | 5mg | $30 | 2024-03-01 | Buy |
| Cayman Chemical | 10009796 | CAY10602 ≥95% | 374922-43-7 | 10mg | $56 | 2024-03-01 | Buy |
CAY10602 Chemical Properties,Uses,Production
Uses
CAY10602 is a SIRT1 activator. CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells[1].
General Description
A cell-permeable pyrroloquinoxaline compound that acts as a reversible SIRT1 activator (10 μM causes ~2.3-fold fluorescent enhancement in a fluorescent assay using hrSIRT1) and enhances fat mobilization in fully differentiated 3T3L1 fibroblasts. Shown to inhibit LPS-induced TNF-α release in THP-1 cells by ~10-fold more potent than resveratrol (Cat. No. 554325).
IC 50
SIRT1
References
[1] Nayagam VM, et al. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen. 2006 Dec;11(8):959-67. DOI:10.1177/1087057106294710
CAY10602 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 021-61312847 13636370518 | shyysw007@163.com | China | 4999 | 60 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28387 | 80 |
