Genz644282
- CAS No.
- 529488-28-6
- Chemical Name:
- Genz644282
- Synonyms
- 2,3-dimethoxy-12-(2-(methylamino)ethyl)-[1,3]dioxolo[4',5':4,5]benzo[1,2-h]benzo[c][1,6]naphthyridin-13(12H)-one;CS-1079;GNZ-644282;Genz644282;GNZ-644282cas;Genz-644282 ，S0093;GENZ644282; GENZ 644282;Genz-644282, 10 mM in DMSO;GENZ-644282;GENZ644282;GENZ 644282;Genz 644282,Inhibitor,inhibit,Genz-644282,Topoisomerase
- CBNumber:
- CB12627899
- Molecular Formula:
- C22H21N3O5
- Molecular Weight:
- 407.42
- MDL Number:
- MFCD25976816
- MOL File:
- 529488-28-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Genz-644282 ≥98% | 24193 | 1mg | $44 |
| Genz-644282 ≥98% | 24193 | 5mg | $205 |
| Genz-644282 ≥98% | 24193 | 10mg | $387 |
| Genz-644282 ≥98% | 24193 | 25mg | $801 |
| GENZ-644282 | TRC-G367760-5MG | 5mg | $288 |
| More product size | |||
| Melting point | 254-257℃ (Decomposition) |
|---|---|
| Boiling point | 665.5±55.0 °C(Predicted) |
| Density | 1.344±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly) |
| form | Solid |
| pka | 9.59±0.10(Predicted) |
| color | Off-White to Pale Yellow |
| FDA UNII | 717I541I2R |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
Genz644282 price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 24193 | Genz-644282 ≥98% | 529488-28-6 | 1mg | $44 | 2026-04-30 | Buy |
| Cayman Chemical | 24193 | Genz-644282 ≥98% | 529488-28-6 | 5mg | $205 | 2026-04-30 | Buy |
| Cayman Chemical | 24193 | Genz-644282 ≥98% | 529488-28-6 | 10mg | $387 | 2026-04-30 | Buy |
| Cayman Chemical | 24193 | Genz-644282 ≥98% | 529488-28-6 | 25mg | $801 | 2026-04-30 | Buy |
| TRC | TRC-G367760-5MG | GENZ-644282 | 529488-28-6 | 5mg | $288 | 2026-06-03 | Buy |
Genz644282 Chemical Properties,Uses,Production
Uses
GENZ-644282 is used in the synthesis of ARC-111 analogs in the improvement of the antitumor activity of the parent compound.
Uses
GENZ-644282 is used in the synthesis of ARC-111 analogs in the improvement of the antitumor activity of the parent compound.
Biological Activity
genz-644282 [8,9-dimethoxy-5-(2-n-methylaminoethyl)-2,3-methylenedioxy-5h-dibenzo[c,h][1,6]naphthyridin-6-one] has emerged as a promising candidate of non-camptothecin topoisomerase i inhibitor for antitumor agents.
in vitro
genz-644282 demonstrated potent cytotoxic activity with a median ic(50) of 1.2 nm (range 0.2-21.9 nm) [1]. limited cross-resistance to genz-644282 was also found in the top1 knockdown colon cancer (hct116) and breast cancer (mcf7) cell lines and in human adenocarcinoma cells (kb31/kbv1) that overexpress (p-glycoprotein, abcb1), a member of the atp-binding cassette family of cell surface transport proteins known to confer mdr [3].
in vivo
genz-644282 at its mtd (4 mg/kg) induced maintained complete responses (mcr) in 6/6 evaluable solid tumor models. at 2 mg/kg genz-644282 induced cr or mcr in 3/3 tumor models relatively insensitive to topotecan, but there were no objective responses at 1 mg/kg [1]. genz-644282 was tolerated at doses up to 4 mg/kg when administered intravenously on alternate days, and the compound was active at doses from 1 to 4 mg/kg. the efficacy of genz-644282 was compared with irinotecan in 4 human colon carcinoma xenograft models. in the human hct-116 colon cancer xenograft, tgd values were 14 days for irinotecan (60 mg/kg) and 34 days for genz-644282 (2.7 mg/kg), giving maximum test to control ratios (t/cs) of 23.7% and 16.8%, respectively [2].
IC 50
1.2 nm [1]
Genz644282 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24569 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9932 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 54746 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
View Lastest Price from Genz644282 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-03 | Genz-644282
529488-28-6
|
$40.00-129.00 | 97.49% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-01-13 | Genz644282
529488-28-6
|
$1.00 | 1g | 99% | 200kg | Career Henan Chemical Co |
-
- Genz-644282
529488-28-6
- $40.00-129.00
- 97.49%
- TargetMol Chemicals Inc.
-
- Genz644282
529488-28-6
- $1.00
- 99%
- Career Henan Chemical Co
