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ChemicalBook >> CAS DataBase List >>(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Structure
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone structure
CAS No.
915095-86-2
Chemical Name:
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Synonyms
Englenet Impurity 16;Empagliflozin Impurity 48;2-chloro-4-fluoro-5-Iodobenzophenon;2-Chloro-4'-fluoro-5-iodobenzophenone;Empagliflozin Impurity 48 /Englenet Impurity 16;(2-Chloro-5-iodobenyl)(4-fluorophenyl)methanone;(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanon;(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone;(2-Chloro-5-sulfophenyl)(4-fluorophenyl)methanone;Methanone, (2-chloro-5-iodophenyl)(4-fluorophenyl)-
CBNumber:
CB12651407
Molecular Formula:
C13H7ClFIO
Molecular Weight:
360.55
MDL Number:
MFCD22665920
MOL File:
915095-86-2.mol
MSDS File:
SDS
Last updated:2026-06-22 20:19:50
Product description Number Pack Size Price
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone TRC-C368575-250MG 250mg $205
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone TRC-C368575-2.5G 2.5g $810
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone TRC-C368575-1G 1g $441
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone >98% PC540099 5g $21
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone >98% PC540099 25g $78
More product size
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(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Properties

Melting point 64-70℃
Boiling point 415℃
Density 1.752
Flash point 205℃
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
solubility Chloroform (Slightly), Ethyl Acetate
form Solid
color Off-White
InChI InChI=1S/C13H7ClFIO/c14-12-6-5-10(16)7-11(12)13(17)8-1-3-9(15)4-2-8/h1-7H
InChIKey KNYGUQLVFSPVRI-UHFFFAOYSA-N
SMILES C(C1=CC(I)=CC=C1Cl)(C1=CC=C(F)C=C1)=O

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Safety Statements  24/25
HS Code  29142990
REACH Registrations Active

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-C368575-250MG (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 915095-86-2 250mg $205 2026-06-03 Buy
TRC TRC-C368575-2.5G (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 915095-86-2 2.5g $810 2026-06-03 Buy
TRC TRC-C368575-1G (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 915095-86-2 1g $441 2026-06-03 Buy
Apolloscientific PC540099 (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone >98% 915095-86-2 5g $21 2026-06-04 Buy
Apolloscientific PC540099 (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone >98% 915095-86-2 25g $78 2026-06-04 Buy
Product number Packaging Price Buy
TRC-C368575-250MG 250mg $205 Buy
TRC-C368575-2.5G 2.5g $810 Buy
TRC-C368575-1G 1g $441 Buy
PC540099 5g $21 Buy
PC540099 25g $78 Buy

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Chemical Properties,Uses,Production

Uses

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone is a reagent in the synthesis of Empagliflozin (E521510); an inhibitor of SGLT-2.

Synthesis

5-Iodo-2-chlorobenzoic acid (20.0 g, 0.071 mol) was added to a solution of 2.0 M oxalyl chloride in dichloromethane (39 ml, 0.078 mol), stirred for suspension, and then 8 drops of DMF solution was added dropwise. The solution was clarified after the reaction was carried out for 3 hours. The solvent was spin-dried on a rotary evaporator, and then 15 ml of methylene chloride was added. After spin-drying, add 30 ml of dichloromethane, stir, cool to 0-5 ° C, add fluorobenzene (7. lg, 0.074 mol), add anhydrous aluminum trichloride (9.9 g, 0.074 mol) in batches, control The temperature is not more than 5 °C, after the completion of the addition, stirring is continued at 4 ° C for 1 h, the reaction is quenched on the ice-water mixture, the organic phase is separated, and the aqueous phase is extracted with dichloromethane. The phase was washed twice with 1 mol/L hydrochloric acid, once with water, and twice with 1 mol/L NaOH solution. The mixture was washed twice with saturated sodium chloride and dried over anhydrous sodium sulfate. Drain filtration, spin dry solvent to obtain oil after column chromatography, 20. 1g (78.6percent) of a white solid (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone was obtained.

References

[1] Patent: CN105399735, 2016, A. Location in patent: Paragraph 0037; 0038; 0039
[2] Patent: US2006/258749, 2006, A1. Location in patent: Page/Page column 21
[3] Organic Letters, 2014, vol. 16, # 16, p. 4090 - 4093
[4] Patent: WO2015/101916, 2015, A1. Location in patent: Page/Page column 18; 19
[5] Patent: CN106928040, 2017, A. Location in patent: Paragraph 0038-0039

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone synthesis

462-06-6
19094-56-5
915095-86-2
Synthesis of (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone from Fluorobenzene and 2-Chloro-5-iodobenzoic acid

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Preparation Products And Raw materials

Raw materials

2-Chloro-5-iodo-benzoyl chloride Fluorobenzene 2-Chloro-5-iodobenzoic acid Dichloromethane Aluminum chloride

Preparation Products

1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene (2-Chloro-5-iodophenyl)(4-ethoxyphenyl)methanone (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Suppliers

Global( 268)Suppliers
Supplier Tel Email Country ProdList Advantage
Chongqing Ensky Pharmaceutical Co.,Ltd.
+86-86-2386815286 +86-13983794297 sales@ensky-chemical.com China 94 58
Suzhou Nordica Biopharma CO.,LTD
+86-18136148818 +86-18567353071 3537297702@qq.com China 299 58
Cangzhou Kangrui Pharma Tech Co. Ltd.,
+86-18632776803 +86-13833998158 cangzhoukangrui@126.com China 773 58
Hebei Yanxi Chemical Co., Ltd. 		+86-17531190177 faithe@yan-xi.com China 5838 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1796 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21531 55
Shandonghaohong biotechnology Co.,ltd. 		0635-6175299 13961496334 sale@inyelchem.com CHINA 44 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10399 58
Supplier Advantage
Chongqing Ensky Pharmaceutical Co.,Ltd.
58
Suzhou Nordica Biopharma CO.,LTD
58
Cangzhou Kangrui Pharma Tech Co. Ltd.,
58
Hebei Yanxi Chemical Co., Ltd. 		58
Capot Chemical Co.,Ltd. 		60
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Shandonghaohong biotechnology Co.,ltd. 		55
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58

View Lastest Price from (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone pictures 2026-06-30 (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2
 1kg 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone pictures 2025-12-24 (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2
 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone pictures 2025-06-20 (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
915095-86-2
 1kg 0.99 20tons Hebei Yanxi Chemical Co., Ltd.

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Spectrum

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone(915095-86-2)1HNMR

915095-86-2((2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone)Related Search:

Acetoxy Empagliflozin Empagliflozin Impurity 23 Empagliflozin (R)-Isomer ((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate N/A
Butanoic acid, 4-chloro-3-hydroxy-, (3S)- (4R,5R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl) phenyl)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol (3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxyMethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol 4-CHLORO-2-FLUOROIODOBENZENE DIPHENYLENEIODONIUM CHLORIDE
(S)-(5-broMo-2-chlorophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)Methanone (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone (2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxyMethyl)-2-Methoxy-2H-pyran-3,4,5-triol
2,3,4,6-Tetra-O-benzyl-a-D-glucopyranosylbromide (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran (R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran

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(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Methanone, (2-chloro-5-iodophenyl)(4-fluorophenyl)- (2-Chloro-5-iodobenyl)(4-fluorophenyl)methanone Empagliflozin Impurity 48 Englenet Impurity 16 2-chloro-4-fluoro-5-Iodobenzophenon (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanon 2-Chloro-4'-fluoro-5-iodobenzophenone (2-Chloro-5-iodine phenyl) 4-fluorophenyl) methylone Empagliflozin Impurity 48 /Englenet Impurity 16 (2-Chloro-5-sulfophenyl)(4-fluorophenyl)methanone 915095-86-2 945065-86-2 C13H7ClFIO