Diphenyleneiodonium chloride
- CAS No.
- 4673-26-1
- Chemical Name:
- Diphenyleneiodonium chloride
- Synonyms
- DPI (Diphenyleneiodonium chloride);DPI;DPI CHLORIDE;ibenziodoliumchloride;DIBENZIODOLIUM CHLORIDE;Dibenz[b,d]iodoliuM Chloride;Diphenyleneiodonium chloride;Diphenyl iodine chloride salt;Dibenziodolium chloride, DPI;Diphenyleneiodoniumchloride(DPI)
- CBNumber:
- CB7355273
- Molecular Formula:
- C12H8ClI
- Molecular Weight:
- 314.55
- MDL Number:
- MFCD00214165
- MOL File:
- 4673-26-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 312-322 °C |
|---|---|
| storage temp. | room temp |
| solubility | Soluble in DMSO (up to 5 mg/ml with warming) |
| form | Powder |
| color | Off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| InChI | InChI=1S/C12H8I.ClH/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11;/h1-8H;1H/q+1;/p-1 |
| InChIKey | FCFZKAVCDNTYID-UHFFFAOYSA-M |
| SMILES | [I+]1C2=C(C=CC=C2)C2=C1C=CC=C2.[Cl-] |
| FDA UNII | 7M9D81YZ2N |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
Diphenyleneiodonium chloride price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D2926 | Diphenyleneiodonium chloride ≥98% | 4673-26-1 | 10mg | $132 | 2026-04-30 | Buy |
| Sigma-Aldrich | D2926 | Diphenyleneiodonium chloride ≥98% | 4673-26-1 | 50mg | $514 | 2026-04-30 | Buy |
| Sigma-Aldrich | 300260 | Diphenyleneiodonium Chloride A cell-permeable, irreversible inhibitor of endothelial nitric oxide synthase (eNOS). | 4673-26-1 | 10 mg | $124 | 2026-04-30 | Buy |
| TCI Chemical | D6364 | Dibenzo[b,d]iodol-5-ium Chloride | 4673-26-1 | 25MG | $86 | 2026-04-30 | Buy |
| TCI Chemical | D6364 | Dibenzo[b,d]iodol-5-ium Chloride | 4673-26-1 | 100MG | $250 | 2026-04-30 | Buy |
Diphenyleneiodonium chloride Chemical Properties, Uses, Production
Description
Diphenyleneiodonium (DPI) is an inhibitor of NADPH oxidase (NOX; EC50 = 0.1 μM in HeLa cells). It also inhibits nitric oxide synthase (NOS; IC50 = 0.05 μM in isolated mouse peritoneal macrophages). DPI (10, 50, and 100 μM) induces the production of reactive oxygen species (ROS) in, and apoptosis of, human umbilical vein endothelial cells (HUVECs). It inhibits NETosis induced by phorbol 12-myristate 13-acetate (PMA; ) in isolated human neutrophils when used at a concentration of 10 μM. DPI (2 mg/kg) reduces tumor growth in HT-29 and LS 174T colon cancer mouse xenograft models.
Chemical Properties
Crystalline Solid
Uses
Binds strongly to flavoproteins and thus inhibits NO synthase, NADG reductase and NADPH oxidase. Solubility: 5 mg in 1.7 mL of H2O:DMSO 40:60; 10 mg in 1.1 mL H2O:DMSO 10:90
Uses
Diphenyleneiodonium Chloride binds strongly to flavoproteins and thus inhibits NO synthase, NADG reductase and NADPH oxidase.Diphenyleneiodonium Chloride solubility: 5 mg in 1.7 mL of H2O:DMSO 40:60; 10 mg in 1.1 mL H2O:DMSO 10:90
Definition
ChEBI: An organic chloride salt having dibenziodolium as the counterion.
Biochem/physiol Actions
A potent and reversible inhibitor of nitric oxide synthetase from macrophages and endothelial cells. Also inhibits other flavoenzymes such as neutrophil NADPH oxidase.
storage
Desiccate at -20°C
References
[1] DENNIS J. STUEHR. Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs1[J]. FASEB Journal, 1991, 5 1: 98-103. DOI:10.1096/fasebj.5.1.1703974
[2] C M YEA O T J A R Cross. Purification and some properties of the 45 kDa diphenylene iodonium-binding flavoprotein of neutrophil NADPH oxidase.[J]. Biochemical Journal, 1990, 265 1: 95-100. DOI:10.1042/bj2650095
[3] CHENLI YE. Identification of a novel small-molecule agonist for human G protein-coupled receptor 3.[J]. Journal of Pharmacology and Experimental Therapeutics, 2014, 349 3: 437-443. DOI:10.1124/jpet.114.213082
[4] Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species
[5] H. KONO. Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat.[J]. American journal of physiology. Gastrointestinal and liver physiology, 2001, 73 1: G1005-12. DOI:10.1152/ajpgi.2001.280.5.g1005
Diphenyleneiodonium chloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Maya High Purity Chemicals | +86 (573) 82222445 (0)18006601000 452520369 | sales@maya-r.com | China | 11693 | 57 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Beijing innoChem Science & Technology Co.,Ltd. | 400-810-7969 010-59572699 | ningzi.li@inno-chem.com.cn | China | 6122 | 55 |
View Latest Price from Diphenyleneiodonium chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | Diphenyleneiodonium chloride
4673-26-1
|
$1.00-22.00 | 1KG | 99% | 100000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2026-07-27 | Diphenyleneiodonium chloride
4673-26-1
|
$38.00-109.00 | 99.86% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-06-20 | DIPHENYLENEIODONIUM CHLORIDE
4673-26-1
|
$40.00 | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. |
-
- Diphenyleneiodonium chloride
4673-26-1
- $1.00-22.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Diphenyleneiodonium chloride
4673-26-1
- $38.00-109.00
- 99.86%
- TargetMol Chemicals Inc.
-
- DIPHENYLENEIODONIUM CHLORIDE
4673-26-1
- $40.00
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
