B-Raf inhibitor 1
- CAS No.
- 1093100-40-3
- Chemical Name:
- B-Raf inhibitor 1
- Synonyms
- CS-927;or Base;B-RAFcas;Raf inhibitor 1;B-Raf inhibitor 1;BRAF inhibitor 13;B-Raf inhibitor 1 Base;B-Raf inhibitor 1, >=98%;Raf inhibitor 1, 10 mM in DMSO;N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine
- CBNumber:
- CB12652787
- Molecular Formula:
- C26H19ClN8
- Molecular Weight:
- 478.94
- MDL Number:
- MFCD22571725
- MOL File:
- 1093100-40-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| B-Raf inhibitor 1 | BISN0223 | 1mg | $75 |
| B-Rafinhibitor1 | B1172 | 5mg | $105 |
| Rafinhibitor1 98.05% | CS-2182 | 5mg | $120 |
| B-Raf inhibitor 1 | BISN0223 | 5mg | $156 |
| Rafinhibitor1 98.05% | CS-2182 | 10mg | $180 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
| HS Code | 2933998090 |
B-Raf inhibitor 1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | BISN0223 | B-Raf inhibitor 1 | 1093100-40-3 | 1mg | $75 | 2021-12-16 | Buy |
| ApexBio Technology | B1172 | B-Rafinhibitor1 | 1093100-40-3 | 5mg | $105 | 2021-12-16 | Buy |
| ChemScene | CS-2182 | Rafinhibitor1 98.05% | 1093100-40-3 | 5mg | $120 | 2021-12-16 | Buy |
| Apolloscientific | BISN0223 | B-Raf inhibitor 1 | 1093100-40-3 | 5mg | $156 | 2021-12-16 | Buy |
| ChemScene | CS-2182 | Rafinhibitor1 98.05% | 1093100-40-3 | 10mg | $180 | 2021-12-16 | Buy |
B-Raf inhibitor 1 Chemical Properties,Uses,Production
Uses
Raf inhibitor 1 is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively.
Biological Activity
B-Raf inhibitor 1 is a potent Raf kinase inhibitor for B-RafWT, B-RafV600E, and C-Raf with Ki of 1 nM, 1 nM, and 0.3 nM, respectively.
in vitro
Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC 50 s of 0.31 and 0.72 μM, respectively. Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif.
target
| B-Raf < span> 1 nM (Ki) | B-Raf V600E 1 nM (Ki) | c-Raf 0.3 nM (Ki ) |
IC 50
B-Raf: 1 nM (Ki); B-RafV600E: 1 nM (Ki); c-Raf: 0.3 nM (Ki)
References
[1] Wang X, et al. Conformation-specific effects of Raf kinase inhibitors. J Med Chem. 2012 Sep 13;55(17):7332-41. DOI:10.1021/jm300613w
B-Raf inhibitor 1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 8511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
View Lastest Price from B-Raf inhibitor 1 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-10 | Raf inhibitor 1
1093100-40-3
|
US $32.00-113.00 / mg | 98.05% | 10g | TargetMol Chemicals Inc. |
-
- Raf inhibitor 1
1093100-40-3
- US $32.00-113.00 / mg
- 98.05%
- TargetMol Chemicals Inc.
