ChemicalBook >> CAS DataBase List >>(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide

(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide

(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide structure

CAS No.: 848193-72-6

Chemical Name:: (S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide

Synonyms: CHIC-35;Compound (S)-35;SIRT1 Inhibitor IV, (S)-35;SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem;(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide;(6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohept[b]indole-6-carboxamide;Cyclohept[b]indole-6-carboxamide, 2-chloro-5,6,7,8,9,10-hexahydro-, (6S)-

CBNumber:: CB12676079

Molecular Formula:: C14H15ClN2O

Molecular Weight:: 262.73

MDL Number:: MFCD11045286

MOL File:: 848193-72-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:24:43

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(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide Properties

storage temp.	2-8°C
solubility	DMSO: >10mg/mL
form	solid
color	off-white
InChI	1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1
InChIKey	ABIVOOWWGYJNLV-JTQLQIEISA-N
SMILES	ClC1=CC=C(NC2=C3CCCC[C@@H]2C(N)=O)C3=C1
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301-H315-H319-H335
Precautionary statements	P261-P301+P310-P305+P351+P338
PPE	dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes	Xn
Risk Statements	36/37/38
Safety Statements	26
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3
Storage Class	11 - Combustible Solids

(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide price More Price(7)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C8742	CHIC-35 ≥97% (chiral, HPLC)	848193-72-6	1mg	$206	2026-04-30	Buy
Sigma-Aldrich	566325	SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem	848193-72-6	500μg	$238	2026-04-30	Buy
aablocks	AA004X0K	(6S)-2-Chloro-5,6,7,8,9,10-hexahydrocyclohept[b]indole-6-carboxamide	848193-72-6	1mg	$238	2026-05-28	Buy
aablocks	AA004X0K	(6S)-2-Chloro-5,6,7,8,9,10-hexahydrocyclohept[b]indole-6-carboxamide	848193-72-6	5mg	$888	2026-05-28	Buy
aablocks	AA004X0K	(6S)-2-Chloro-5,6,7,8,9,10-hexahydrocyclohept[b]indole-6-carboxamide	848193-72-6	25mg	$2633	2026-05-28	Buy

Product number	Packaging	Price	Buy
C8742	1mg	$206	Buy
566325	500μg	$238	Buy
AA004X0K	1mg	$238	Buy
AA004X0K	5mg	$888	Buy
AA004X0K	25mg	$2633	Buy

(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide Chemical Properties, Uses, Production

Uses

CHIC35, an analog of EX-527, is a potent and selective inhibitor of SIRT1 (IC50=0.124 μM). CHIC35 shows potential selective inhibition against SIRT1 over SIRT2 (IC50=2.8 μM) or SIRT3 (IC50>100 μM)[1]. CHIC35 has anti-inflammatory effects and can be used for CHARGE syndrome research[1][2].

Definition

ChEBI: CHIC-35 is an organic heterotricyclic compound resulting from the formal fusion of the 2-3 bond of 5-chloroindole with the 2-3 bond of cycloheptanecarboxamide (the S enantiomer). It is a potent, cell-permeable, metabolically stable and selective inhibitor of the deacetylase SIRT1. It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor. It is an aromatic compound, an organic heterotricyclic compound, an organochlorine compound and a primary carboxamide.

General Description

A cell-permeable entiomerically pure compound that is structurally similar to and exhibits similar potency (IC₅₀ = 63 nM) and selectivity as SIRT1 Inhibitor III (Cat. No. 566322). Shown to be orally bioavailable with a serum half-life of 94 minutes in mice in vivo.

Biochem/physiol Actions

CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC50 for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.

IC 50

SIRT1: 0.124 μM (IC₅₀); SIRT2: 2.8 μM (IC₅₀); SIRT3: >100 μM (IC₅₀)

References

[1] Jérme Lugrin, et al. The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock. Biochim Biophys Acta. 2013 Jun;1833(6):1498-510 DOI:10.1016/j.bbamcr.2013.03.004
[2] Zainab Asad, et al. Chemical screens in a zebrafish model of CHARGE syndrome identifies small molecules that ameliorate disease-like phenotypes in embryo. Eur J Med Genet. 2020 Feb;63(2):103661. DOI:10.1016/j.ejmg.2019.04.018

(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide Suppliers

Global Suppliers ( 12)

Supplier	Tel	Email	Country	ProdList	Advantage
Syntechem Co.,Ltd		info@syntechem.com	China	12973	57
Shanghai Macklin Biochemical Co.,Ltd.	15221275939 15221275939	shenlinxing@macklin.cn	China	15775	55
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58
TargetMol Chemicals Inc.	13564774135	marketing@targetmol.com	United States	19950	58

Supplier	Advantage
Syntechem Co.,Ltd	57
Shanghai Macklin Biochemical Co.,Ltd.	55
Sigma-Aldrich	80
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58

View Latest Price from (S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-05-11	CHIC35 848193-72-6	$1670.00-2800.00			10g	TargetMol Chemicals Inc.

CHIC35
848193-72-6
$1670.00-2800.00
TargetMol Chemicals Inc.

848193-72-6 ((S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide) Related Search:

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(6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohept[b]indole-6-carboxamide CHIC-35 Compound (S)-35 SIRT1 Inhibitor IV, (S)-35 (S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem Cyclohept[b]indole-6-carboxamide, 2-chloro-5,6,7,8,9,10-hexahydro-, (6S)- 848193-72-6