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ChemicalBook >> CAS DataBase List >> (S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide

(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide

(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide price.
  • $206 - $2633
  • Product name: (S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide
  • CAS: 848193-72-6
  • MF: C14H15ClN2O
  • MW: 262.73
  • EINECS:
  • MDL Number:MFCD11045286
  • Synonyms:(6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohept[b]indole-6-carboxamide;CHIC-35;Compound (S)-35;SIRT1 Inhibitor IV, (S)-35;(S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxaMide;SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem;Cyclohept[b]indole-6-carboxamide, 2-chloro-5,6,7,8,9,10-hexahydro-, (6S)-
Price7 Properties Safety Information Description
7 prices
Selected condition：
Brand
  • aablocks
  • American Custom Chemicals Corporation
  • Sigma-Aldrich
Package
  • 500μg
  • 1mg
  • 5mg
  • 25mg
  • Manufactureraablocks
  • Product numberAA004X0K
  • Product description(6S)-2-Chloro-5,6,7,8,9,10-hexahydrocyclohept[b]indole-6-carboxamide
  • Packaging1mg
  • Price$238
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA004X0K
  • Product description(6S)-2-Chloro-5,6,7,8,9,10-hexahydrocyclohept[b]indole-6-carboxamide
  • Packaging5mg
  • Price$888
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA004X0K
  • Product description(6S)-2-Chloro-5,6,7,8,9,10-hexahydrocyclohept[b]indole-6-carboxamide
  • Packaging25mg
  • Price$2633
  • Updated2026-05-28
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0004657
  • Product description(6S)-2-CHLORO-5,6,7,8,9,10-HEXAHYDRO-CYCLOHEPT[B]INDOLE-6-CARBOXAMIDE 95.00%
  • Packaging5MG
  • Price$498.64
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberC8742
  • Product descriptionCHIC-35 ≥97% (chiral, HPLC)
  • Packaging5mg
  • Price$610
  • Updated2026-04-30
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberC8742
  • Product descriptionCHIC-35 ≥97% (chiral, HPLC)
  • Packaging1mg
  • Price$206
  • Updated2026-04-30
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number566325
  • Product descriptionSIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem
  • Packaging500μg
  • Price$238
  • Updated2026-04-30
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA004X0K (6S)-2-Chloro-5,6,7,8,9,10-hexahydrocyclohept[b]indole-6-carboxamide 1mg $238 2026-05-28 Buy
aablocks AA004X0K (6S)-2-Chloro-5,6,7,8,9,10-hexahydrocyclohept[b]indole-6-carboxamide 5mg $888 2026-05-28 Buy
aablocks AA004X0K (6S)-2-Chloro-5,6,7,8,9,10-hexahydrocyclohept[b]indole-6-carboxamide 25mg $2633 2026-05-28 Buy
American Custom Chemicals Corporation INB0004657 (6S)-2-CHLORO-5,6,7,8,9,10-HEXAHYDRO-CYCLOHEPT[B]INDOLE-6-CARBOXAMIDE 95.00% 5MG $498.64 2021-12-16 Buy
Sigma-Aldrich C8742 CHIC-35 ≥97% (chiral, HPLC) 5mg $610 2026-04-30 Buy
Sigma-Aldrich C8742 CHIC-35 ≥97% (chiral, HPLC) 1mg $206 2026-04-30 Buy
Sigma-Aldrich 566325 SIRT1 Inhibitor IV, (S)-35 - CAS 848193-72-6 - Calbiochem 500μg $238 2026-04-30 Buy

Properties

storage temp. :2-8°C
solubility :DMSO: >10mg/mL
form :solid
color :off-white
InChI :1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1
InChIKey :ABIVOOWWGYJNLV-JTQLQIEISA-N
SMILES :ClC1=CC=C(NC2=C3CCCC[C@@H]2C(N)=O)C3=C1

Safety Information

Symbol(GHS): Skull and Crossbones (GHS06)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SIRT 1 inhibitor IV, (S)-35 is a highly potent inhibitor of SIRT1 (IC50 = 38 nM). It is an entomerically pure compound that can permeate the cell and is metabolically stable. The inhibitor is similar in structure, potency (IC50 = 63 nM), and selectivity to SIRT1 inhibitor III. Sirt4-7 and class I/II HDAC are not inhibited by SIRT1 inhibitor (concentrations up to 100μM). Data shows that inhibition of SIRT1 by SIRT1 Inhibitor IV, (S)-35 enhances acetylation of p53 in response to DNA damaging agents.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
CHIC35
$1670.00
CHIC35 CAS:848193-72-6
Syntechem Co.,Ltd Shanghai Macklin Biochemical Co.,Ltd. Sigma-Aldrich TargetMol Chemicals Inc. TargetMol Chemicals Inc.