4-Chloro-3-(trifluoromethoxy)benzoic acid
- CAS No.
- 886500-50-1
- Chemical Name:
- 4-Chloro-3-(trifluoromethoxy)benzoic acid
- Synonyms
- 4-Chloro-3-(trifluoromethoxy)benzoic acid;Benzoic acid, 4-chloro-3-(trifluoroMethoxy)-
- CBNumber:
- CB7129805
- Molecular Formula:
- C8H4ClF3O3
- Molecular Weight:
- 240.56
- MDL Number:
- MFCD06660238
- MOL File:
- Mol file
- MSDS File:
- SDS
| Melting point | 123-126℃ |
|---|---|
| Boiling point | 276.6±35.0℃ (760 Torr) |
| Density | 1.558±0.06 g/cm3 (20 ºC 760 Torr) |
| Flash point | 121.1±25.9℃ |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 3.59±0.10(Predicted) |
| Appearance | white solid |
| Water Solubility | Sparingly Soluble in water. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2916399090 | |||||||||
| NFPA 704 |
|
4-Chloro-3-(trifluoromethoxy)benzoic acid price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC302741 | 4-Chloro-3-(trifluoromethoxy)benzoic acid 99% | 886500-50-1 | 1g | $41 | 2026-06-04 | Buy |
| Apolloscientific | PC302741 | 4-Chloro-3-(trifluoromethoxy)benzoic acid 99% | 886500-50-1 | 5g | $115 | 2026-06-04 | Buy |
| Apolloscientific | PC302741 | 4-Chloro-3-(trifluoromethoxy)benzoic acid 99% | 886500-50-1 | 25g | $410 | 2026-06-04 | Buy |
| Matrix Scientific | 094569 | 4-Chloro-3-(trifluoromethoxy)benzoic acid | 886500-50-1 | 1.00g | $145 | 2026-05-18 | Buy |
| Matrix Scientific | 094569 | 4-Chloro-3-(trifluoromethoxy)benzoic acid | 886500-50-1 | 5.00g | $260 | 2026-05-18 | Buy |
4-Chloro-3-(trifluoromethoxy)benzoic acid Chemical Properties,Uses,Production
Uses
4-Chloro-3-(trifluoromethoxy)benzoic acid is used as pharmaceuticals intermediates.
Synthesis
1261444-00-1
886500-50-1
General procedure for the synthesis of 4-chloro-3-trifluoromethoxybenzoic acid from methyl 4-chloro-3-(trifluoromethoxy)benzoate: to a methanol (30 mL) solution containing methyl 4-chloro-3-(trifluoromethoxy)benzoate (3.1 g, 12.18 mmol) was slowly added sodium hydroxide (1.46 g, 36.50 mmol) in a water ( 10mL) solution. The reaction mixture was stirred continuously for 1.5 hours at room temperature. Upon completion of the reaction, the pH of the reaction mixture was adjusted with 36% hydrochloric acid solution to 4. Subsequently, the solution was extracted with ethyl acetate (3 x 100 mL), all organic layers were combined and dried with anhydrous sodium sulfate. After filtration to remove solid impurities, the mixture was concentrated under reduced pressure to afford the target product 4-chloro-3-(trifluoromethoxy)benzoic acid as a light yellow solid (2.10 g, 74% yield). The product was analyzed by LC/MS (ES, m/z) to confirm: [M + H]+ 241.0. 1H NMR (300 MHz, DMSO) data were as follows: δ 7.92-7.99 (m, 2H), 7.40-7.47 (m, 1H).
References
[1] Patent: WO2014/66795, 2014, A1. Location in patent: Paragraph 0175
4-Chloro-3-(trifluoromethoxy)benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Ansciep Chemical Co., Ltd. | 0519-86305871 | tina@ansciepchem.com | China | 1987 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3993 | 55 |
| Shanghai Yolne Chemical Co., Ltd. | 021-62960152 | 934678158@qq.com | China | 9886 | 55 |
| Tianjin Ji Ping Jia Chemical Co., Ltd. | 18622448868 | jpjchem@163.com | China | 489 | 62 |
| Jalor-Chem co.,LTD | 0510-0510-86396359 13382276200 | sales@jalor-chem.com | China | 1000 | 56 |
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 3014 | 58 |
