Isoquinoline-5-sulphonyl chloride hydrochloride
- CAS No.
- 105627-79-0
- Chemical Name:
- Isoquinoline-5-sulphonyl chloride hydrochloride
- Synonyms
- Fasudil Impurity 30 HCl;Isoquinoline-5-Sulphonyl;isoquinolin-5-sulfonyl chloride HCl;5-Isoquinolinesulfonyl chloride HCl;Isoquinolin-5-sulphonyl chloride HCl;Isoquinoline-5-sulphonyl chloride, HCl;5-(Chlorosulphonyl)isoquinoline hydrochloride;5-Isoquinolinesulfonyl chloride, hydrochloride;ISOQUINOLINE-5-SULPHONYL CHLORIDE HYDROCHLORIDE;isoquinolin-5-ylsulphonyl chloride hydrochloride
- CBNumber:
- CB1270334
- Molecular Formula:
- C9H7Cl2NO2S
- Molecular Weight:
- 264.12
- MDL Number:
- MFCD08272853
- MOL File:
- 105627-79-0.mol
- MSDS File:
- SDS
Isoquinoline-5-sulphonyl chloride hydrochloride price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | I9080-20 | Isoquinoline-5-sulfonyl Chloride, Hydrochloride | 105627-79-0 | 1g | $446 | 2026-06-03 | Buy |
| TRC | TRC-I878000-500MG | Isoquinoline-5-sulfonyl Chloride, Hydrochloride | 105627-79-0 | 500mg | $179 | 2026-06-03 | Buy |
| TRC | TRC-I878000-1G | Isoquinoline-5-sulfonyl Chloride, Hydrochloride | 105627-79-0 | 1g | $221 | 2026-06-03 | Buy |
| Apolloscientific | OR9017 | Isoquinoline-5-sulphonyl chloride hydrochloride 95% | 105627-79-0 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR9017 | Isoquinoline-5-sulphonyl chloride hydrochloride 95% | 105627-79-0 | 1g | $41 | 2026-06-04 | Buy |
Isoquinoline-5-sulphonyl chloride hydrochloride Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Isoquinoline-5-sulfonyl Chloride, Hydrochloride (cas# 105627-79-0) is a compound useful in organic synthesis.
Synthesis
27655-40-9
105627-79-0
Anhydrous DMF (1.5 mL) was added slowly and dropwise to the suspension formed by stirring 5-isoquinolinesulfonic acid (28.3 g, 135 mmol) with thionyl chloride (150 mL, 2.06 mol) at room temperature and under nitrogen protection. The reaction mixture was heated to reflux and maintained for 2.5 hours. After completion of the reaction, it was cooled to room temperature and subsequently concentrated under reduced pressure to give a light yellow powder. The powder was suspended in anhydrous dichloromethane (200 mL), sonicated, filtered, and dried under reduced pressure at 40 °C to yield a final isoquinoline-5-sulfonyl chloride hydrochloride 29.2 g (111 mmol, 82% yield). The structure of the product was confirmed by 1H NMR (TFA-d): δ 8.48 (t, J = 7.9 Hz, 1H), 9.13-9.14 (m, 2H), 9.29 (d, J = 7.9 Hz, 1H), 9.57 (d, J = 7.0 Hz, 1H), 10.26 (s, 1H).
References
[1] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 9, p. 2317 - 2333
[2] Journal of Medicinal Chemistry, 1989, vol. 32, # 1, p. 42 - 46
[3] Journal of Medicinal Chemistry, 1989, vol. 32, # 1, p. 46 - 50
[4] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 9, p. 5277 - 5284
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 14, p. 5922 - 5933
Isoquinoline-5-sulphonyl chloride hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Chembon Pharmaceutical Co., Ltd. | 028-84252981 18583719936 | sales@chembon.com.cn | China | 854 | 64 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6746 | 52 |
View Lastest Price from Isoquinoline-5-sulphonyl chloride hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | Isoquinoline-5-sulphonyl chloride hydrochloride
105627-79-0
|
$1.00 | 1kg | 95%-99% | 100kg | Career Henan Chemical Co |
-
- Isoquinoline-5-sulphonyl chloride hydrochloride
105627-79-0
- $1.00
- 95%-99%
- Career Henan Chemical Co
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