Isoquinoline-5-sulfonyl chloride
- CAS No.
- 84468-15-5
- Chemical Name:
- Isoquinoline-5-sulfonyl chloride
- Synonyms
- Isoquinoline Impurity 6;5-Isoquinolinesulfonyl chloride;Isoquinoline-5-sulfonyl chloride;isoquinolin-5-ylsulphonyl chloride;Isoquinoline-5-sulfonylchlorideHCl;5-Isoquinolinesulfonylchloride(9CI);Isoquinoline-5-sulfonyl chloride - [K9349];ISOQUINOLINE-5-SULFONYL CHLORIDE, HYDROCHLORIDE;ISOQUINOLINE-5-SULFONYL CHLORIDE ISO 9001：2015 REACH;Isoquinoline-5-sulfonyl chloride reference substance
- CBNumber:
- CB5397402
- Molecular Formula:
- C9H6ClNO2S
- Molecular Weight:
- 227.67
- MDL Number:
- MFCD00270016
- MOL File:
- 84468-15-5.mol
| Melting point | 173-183°C |
|---|---|
| Boiling point | 371.2±17.0 °C(Predicted) |
| Density | 1.483 |
| Flash point | 178.3℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Sparingly, Heated) |
| form | Solid |
| pka | 3.09±0.13(Predicted) |
| color | White to Off-White |
| Stability | Moisture Sensitive |
| CAS DataBase Reference | 84468-15-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P260-P280-P303+P361+P353-P301+P330+P331-P304+P340+P310-P305+P351+P338+P310 |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36/37 |
| HS Code | 29334900 |
Isoquinoline-5-sulfonyl chloride price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS15153-A | Isoquinoline-5-sulfonyl chloride 95% | 84468-15-5 | 1g | $361 | 2026-06-04 | Buy |
| Matrix Scientific | 308889 | Isoquinoline-5-sulfonyl chloride | 84468-15-5 | 100.00mg | $58 | 2026-05-19 | Buy |
| Matrix Scientific | 308889 | Isoquinoline-5-sulfonyl chloride | 84468-15-5 | 250.00mg | $102 | 2026-05-19 | Buy |
| Matrix Scientific | 308889 | Isoquinoline-5-sulfonyl chloride | 84468-15-5 | 1.00g | $267 | 2026-05-19 | Buy |
| Synthonix | K9349 | Isoquinoline-5-sulfonyl chloride 95% | 84468-15-5 | 100mg | $60 | 2026-05-06 | Buy |
Isoquinoline-5-sulfonyl chloride Chemical Properties,Uses,Production
Chemical Properties
Colourless Crystalline Solid
Synthesis
27655-40-9
84468-15-5
The general procedure for the synthesis of isoquinoline-5-sulfonyl chloride from 5-isoquinolinesulfonic acid was as follows: 5-isoquinolinesulfonic acid was placed in a round-bottomed flask, 6 mL of thionyl chloride and 1 drop of N,N-dimethylformamide (DMF) were added, and the reaction was carried out at reflux for 3 hours. Upon completion of the reaction, the excess thionyl chloride was removed using a rotary evaporator. Dichloromethane (DCM) was added to the residual solid and the solid product was collected by filtration. The solid was washed three times with DCM and subsequently dried in a vacuum oven to give a white solid intermediate 2 (1 g, 91.9% yield). Intermediate 2 (130.00 mg, 571.01 μmol) was slowly added to a solution of DCM (6 mL) containing ethylenediamine (381.30 μL, 5.71 mmol) under ice-bath conditions. After removing the ice bath, the mixture was allowed to react for 3 h at room temperature. Upon completion of the reaction, the mixture was washed with water to remove the remaining ethylenediamine. The organic phase was removed using a rotary evaporator and the residue was recrystallized by ether to give brown solid 3 (91.8 mg, 60% yield).
References
[1] Patent: US2017/37050, 2017, A1. Location in patent: Paragraph 0064; 0068; 0069
[2] Patent: CN106279136, 2017, A. Location in patent: Paragraph 0022
[3] Patent: US5891909, 1999, A
[4] Patent: US6235778, 2001, B1
[5] Patent: EP906091, 2006, B1. Location in patent: Page/Page column 48
Isoquinoline-5-sulfonyl chloride Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan EnTai Technology Development Co,.Ltd | 86-27-82330560 | 2536851935@qq.com | China | 346 | 69 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1399 | 59 |
| Chembon Pharmaceutical Co., Ltd. | 028-84252981 18583719936 | sales@chembon.com.cn | China | 854 | 64 |
| Wuhan Haizheng Industry & Trade Development Co. Ltd | 027-8866 0053/88660577/88660578 | China | 1070 | 55 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Wuhan Chemduro Pharm Tech Co. Ltd. | 18040571231/1402788087 | China | 1972 | 58 | |
| ShangHai KenEn Chemical Technology Co., Ltd. | 13120367189;18621755571 | mychess007@163.com | China | 1994 | 55 |
| NovoChemy Ltd. | 86-(0)21-31261262 373522135 | sales@novochemy.com | China | 6491 | 58 |
View Lastest Price from Isoquinoline-5-sulfonyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-26 | Isoquinoline-5-sulfonyl chloride
84468-15-5
|
1KG | 99.0%+ | 600 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2019-07-06 | ISOQUINOLINE-5-SULFONYL CHLORIDE
84468-15-5
|
$1.00 | 1kg | 95%-99% | 100kg | Career Henan Chemical Co |
-
- Isoquinoline-5-sulfonyl chloride
84468-15-5
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd
-
- ISOQUINOLINE-5-SULFONYL CHLORIDE
84468-15-5
- $1.00
- 95%-99%
- Career Henan Chemical Co
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