ISOQUINOLINE-5-SULFONYL CHLORIDE
- CAS No.
- 84468-15-5
- Chemical Name:
- ISOQUINOLINE-5-SULFONYL CHLORIDE
- Synonyms
- Isoquinoline Impurity 6;5-Isoquinolinesulfonyl chloride;ISOQUINOLINE-5-SULFONYL CHLORIDE;isoquinolin-5-ylsulphonyl chloride;Isoquinoline-5-sulfonylchlorideHCl;5-Isoquinolinesulfonylchloride(9CI);Isoquinoline-5-sulfonyl chloride - [K9349];ISOQUINOLINE-5-SULFONYL CHLORIDE, HYDROCHLORIDE;ISOQUINOLINE-5-SULFONYL CHLORIDE ISO 9001：2015 REACH;Isoquinoline-5-sulfonyl chloride reference substance
- CBNumber:
- CB5397402
- Molecular Formula:
- C9H6ClNO2S
- Molecular Weight:
- 227.67
- MDL Number:
- MFCD00270016
- MOL File:
- 84468-15-5.mol
| Product description | Number | Pack Size | Price |
| Isoquinoline-5-sulfonyl chloride 95% | AS15153-A | 1g | $361 |
| Isoquinoline-5-sulfonyl chloride | 308889 | 100.00mg | $58 |
| Isoquinoline-5-sulfonyl chloride | 308889 | 250.00mg | $102 |
| Isoquinoline-5-sulfonyl chloride | 308889 | 1.00g | $267 |
| Isoquinoline-5-sulfonyl chloride 95% | K9349 | 100mg | $60 |
| More product size | |||
| Melting point | 173-183°C |
|---|---|
| Boiling point | 371.2±17.0 °C(Predicted) |
| Density | 1.483 |
| Flash point | 178.3℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Sparingly, Heated) |
| form | Solid |
| pka | 3.09±0.13(Predicted) |
| color | White to Off-White |
| Stability | Moisture Sensitive |
| CAS DataBase Reference | 84468-15-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P260-P280-P303+P361+P353-P301+P330+P331-P304+P340+P310-P305+P351+P338+P310 |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36/37 |
| HS Code | 29334900 |
ISOQUINOLINE-5-SULFONYL CHLORIDE price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS15153-A | Isoquinoline-5-sulfonyl chloride 95% | 84468-15-5 | 1g | $361 | 2026-06-04 | Buy |
| Matrix Scientific | 308889 | Isoquinoline-5-sulfonyl chloride | 84468-15-5 | 100.00mg | $58 | 2026-05-19 | Buy |
| Matrix Scientific | 308889 | Isoquinoline-5-sulfonyl chloride | 84468-15-5 | 250.00mg | $102 | 2026-05-19 | Buy |
| Matrix Scientific | 308889 | Isoquinoline-5-sulfonyl chloride | 84468-15-5 | 1.00g | $267 | 2026-05-19 | Buy |
| Synthonix | K9349 | Isoquinoline-5-sulfonyl chloride 95% | 84468-15-5 | 100mg | $60 | 2026-05-06 | Buy |
ISOQUINOLINE-5-SULFONYL CHLORIDE Chemical Properties,Uses,Production
Chemical Properties
Colourless Crystalline Solid
Synthesis
27655-40-9
84468-15-5
The general procedure for the synthesis of isoquinoline-5-sulfonyl chloride from 5-isoquinolinesulfonic acid was as follows: 5-isoquinolinesulfonic acid was placed in a round-bottomed flask, 6 mL of thionyl chloride and 1 drop of N,N-dimethylformamide (DMF) were added, and the reaction was carried out at reflux for 3 hours. Upon completion of the reaction, the excess thionyl chloride was removed using a rotary evaporator. Dichloromethane (DCM) was added to the residual solid and the solid product was collected by filtration. The solid was washed three times with DCM and subsequently dried in a vacuum oven to give a white solid intermediate 2 (1 g, 91.9% yield). Intermediate 2 (130.00 mg, 571.01 μmol) was slowly added to a solution of DCM (6 mL) containing ethylenediamine (381.30 μL, 5.71 mmol) under ice-bath conditions. After removing the ice bath, the mixture was allowed to react for 3 h at room temperature. Upon completion of the reaction, the mixture was washed with water to remove the remaining ethylenediamine. The organic phase was removed using a rotary evaporator and the residue was recrystallized by ether to give brown solid 3 (91.8 mg, 60% yield).
References
[1] Patent: US2017/37050, 2017, A1. Location in patent: Paragraph 0064; 0068; 0069
[2] Patent: CN106279136, 2017, A. Location in patent: Paragraph 0022
[3] Patent: US5891909, 1999, A
[4] Patent: US6235778, 2001, B1
[5] Patent: EP906091, 2006, B1. Location in patent: Page/Page column 48
ISOQUINOLINE-5-SULFONYL CHLORIDE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chembon Pharmaceutical Co., Ltd. | +86-28-8425-2981 | CHINA | 722 | 55 | |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3967 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52704 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9653 | 58 |
View Lastest Price from ISOQUINOLINE-5-SULFONYL CHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-26 | Isoquinoline-5-sulfonyl chloride
84468-15-5
|
1KG | 99.0%+ | 600 tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2019-07-06 | ISOQUINOLINE-5-SULFONYL CHLORIDE
84468-15-5
|
$1.00 | 1kg | 95%-99% | 100kg | Career Henan Chemical Co |
-
- Isoquinoline-5-sulfonyl chloride
84468-15-5
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd
-
- ISOQUINOLINE-5-SULFONYL CHLORIDE
84468-15-5
- $1.00
- 95%-99%
- Career Henan Chemical Co
84468-15-5(ISOQUINOLINE-5-SULFONYL CHLORIDE)Related Search:
1of4
