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2-Amino-3-cyano-4,5-dimethylpyrrole

2-Amino-3-cyano-4,5-dimethylpyrrole structure

CAS No.: 21392-51-8

Chemical Name:: 2-Amino-3-cyano-4,5-dimethylpyrrole

Synonyms: AT-51109;2-AMino-3-cyano-4,5-;2-amino-4,5-dimethyl-1H-pyrrol;2-AMINO-3-CYANO-4,5-DIMETHYLPYRROLE;2-AMINO-3-CYANO-4,5-DIMETHYL-1H-PYRROLE;2-Amino-4,5-dimethylpyrrole-3-carbonitrile;2-AMINO-4,5-DIMETHYL-1H-PYRROLE-3-CARBONITRILE;1H-Pyrrole-3-carbonitrile, 2-amino-4,5-dimethyl-

CBNumber:: CB1278693

Molecular Formula:: C7H9N3

Molecular Weight:: 135.17

MDL Number:: MFCD00849263

MOL File:: 21392-51-8.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:47

Product description	Number	Pack Size	Price
2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile	A634695	500mg	$75
2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile	3H37-1-P8	5G	$31
2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile	3H37-1-P8	1g	$16
2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile >95%	043941	500mg	$118
2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile	V0647	25g	$121
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2-Amino-3-cyano-4,5-dimethylpyrrole Properties

Melting point	178-181°C
Boiling point	366.2±42.0 °C(Predicted)
Density	1.17±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	18.46±0.50(Predicted)
Appearance	Brown to reddish brown Solid
CAS DataBase Reference	21392-51-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302+H312+H332
Precautionary statements	P260-P271-P280
Hazard Codes	Xi,Xn
Risk Statements	20/21/22-41-37/38-22
Safety Statements	26-36/37/39-39
RIDADR	3439
HazardClass	IRRITANT
HS Code	2933998090

2-Amino-3-cyano-4,5-dimethylpyrrole price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	A634695	2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile	21392-51-8	500mg	$75	2021-12-16	Buy
SynQuest Laboratories	3H37-1-P8	2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile	21392-51-8	5G	$31	2021-12-16	Buy
SynQuest Laboratories	3H37-1-P8	2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile	21392-51-8	1g	$16	2021-12-16	Buy
Matrix Scientific	043941	2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile >95%	21392-51-8	500mg	$118	2021-12-16	Buy
AK Scientific	V0647	2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile	21392-51-8	25g	$121	2021-12-16	Buy

Product number	Packaging	Price	Buy
A634695	500mg	$75	Buy
3H37-1-P8	5G	$31	Buy
3H37-1-P8	1g	$16	Buy
043941	500mg	$118	Buy
V0647	25g	$121	Buy

2-Amino-3-cyano-4,5-dimethylpyrrole Chemical Properties,Uses,Production

Synthesis

6628-81-5

109-77-3

21392-51-8

A mixture of acetic anhydride (16.9 g, 165 mmol), acetic acid (2.26 g, 37.6 mmol), triethylamine (19 g, 188 mmol), and 4-(dimethylamino)pyridine (0.1 g, 0.75 mmol) was added to a reaction flask and heated to 50 °C. Racemic alanine (6.79 g, 76.2 mmol) was added in small batches over a period of 4 h under stirring while maintaining the reaction temperature in the range of 45-55 °C. The reaction was carried out at a constant temperature in the range of 45-55 °C. The reaction temperature was kept at a constant temperature in the range of 45-55 °C. After the alanine addition was completed, the red mixture was continued to be stirred at 50 °C for 8 hours. Subsequently, acetic anhydride, acetic acid and triethylamine were removed by vacuum distillation (15-20 mbar) and the temperature of the system was gradually raised to a maximum of 100 °C. The residue of the resulting acylamino ketone intermediate (246) was cooled to room temperature and water (40 mL) was added. Next, malononitrile (4.71 g, 71.3 mmol) was added and the reaction mixture was slowly poured into 30% aqueous sodium hydroxide solution (25 mL), ensuring that the reaction temperature did not exceed 60 °C. The resulting mixture was cooled to 0 °C, filtered, washed with water (45 mL), and dried under vacuum to give 6.65 g of pyrrole derivative (7) in beige solid form in 66% yield; the melting point was 163-165 °C (literature value) [24].

References

[1] Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990, vol. 29, # 1, p. 47 - 52
[2] Bioorganic Chemistry, 2018, vol. 81, p. 612 - 629
[3] Pharmazie, 1989, vol. 44, # 12, p. 814 - 816
[4] Chimia, 2004, vol. 58, # 9, p. 640 - 648
[5] Organic Process Research and Development, 2001, vol. 5, # 6, p. 581 - 586

2-Amino-3-cyano-4,5-dimethylpyrrole Preparation Products And Raw materials

Raw materials

N-(1-methyl-2-oxopropyl)acetamide L-Alanine Acetic anhydride Malononitrile Sodium hydroxide

Water

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Preparation Products

2-Amino-3-cyano-4,5-dimethylpyrrole Suppliers

Global( 92)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29794	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
PT CHEM GROUP LIMITED	+86-85511178;	peter68@ptchemgroup.com	China	35425	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49968	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
PT CHEM GROUP LIMITED	58
GIHI CHEMICALS CO.,LIMITED	58
Aladdin Scientific	58

View Lastest Price from 2-Amino-3-cyano-4,5-dimethylpyrrole manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-08-12	2-Amino-3-cyano-4,5-dimethylpyrrole 21392-51-8	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
	2020-01-01	2-Amino-3-cyano-4,5-dimethylpyrrole 21392-51-8	US $1.00 / IU	1KG	99%	500kg	Career Henan Chemical Co

2-Amino-3-cyano-4,5-dimethylpyrrole
21392-51-8
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2-Amino-3-cyano-4,5-dimethylpyrrole
21392-51-8
US $1.00 / IU
99%
Career Henan Chemical Co

2-Amino-3-cyano-4,5-dimethylpyrrole Spectrum

2-Amino-3-cyano-4,5-dimethylpyrrole(21392-51-8)¹HNMR

21392-51-8(2-Amino-3-cyano-4,5-dimethylpyrrole)Related Search:

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2-AMINO-3-CYANO-4,5-DIMETHYL-1H-PYRROLE 2-AMINO-3-CYANO-4,5-DIMETHYLPYRROLE AT-51109 2-AMINO-4,5-DIMETHYL-1H-PYRROLE-3-CARBONITRILE 2-amino-4,5-dimethyl-1H-pyrrol 1H-Pyrrole-3-carbonitrile, 2-amino-4,5-dimethyl- 2-AMino-3-cyano-4,5- 2-Amino-4,5-dimethylpyrrole-3-carbonitrile 21392-51-8 C7H9N3 Pyrroles & Indoles Non-Chiral heterocyclic compounds Benzenes Amines Pyrroles & Indoles API intermediates Heterocycle intermediates