2-Amino-3-cyano-4,5-dimethylpyrrole
- CAS No.
- 21392-51-8
- Chemical Name:
- 2-Amino-3-cyano-4,5-dimethylpyrrole
- Synonyms
- AT-51109;2-AMino-3-cyano-4,5-;2-amino-4,5-dimethyl-1H-pyrrol;2-AMINO-3-CYANO-4,5-DIMETHYLPYRROLE;2-AMINO-3-CYANO-4,5-DIMETHYL-1H-PYRROLE;2-Amino-4,5-dimethylpyrrole-3-carbonitrile;2-AMINO-4,5-DIMETHYL-1H-PYRROLE-3-CARBONITRILE;1H-Pyrrole-3-carbonitrile, 2-amino-4,5-dimethyl-
- CBNumber:
- CB1278693
- Molecular Formula:
- C7H9N3
- Molecular Weight:
- 135.17
- MDL Number:
- MFCD00849263
- MOL File:
- 21392-51-8.mol
- MSDS File:
- SDS
| Melting point | 178-181°C |
|---|---|
| Boiling point | 366.2±42.0 °C(Predicted) |
| Density | 1.17±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 18.46±0.50(Predicted) |
| Appearance | Brown to reddish brown Solid |
| CAS DataBase Reference | 21392-51-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332 |
| Precautionary statements | P260-P271-P280 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 20/21/22-41-37/38-22 |
| Safety Statements | 26-36/37/39-39 |
| RIDADR | 3439 |
| HazardClass | IRRITANT |
| HS Code | 2933998090 |
2-Amino-3-cyano-4,5-dimethylpyrrole price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 56035 | 2-AMINO-3-CYANO-4,5-DIMETHYLPYRROLE 98% | 21392-51-8 | 5G | $34 | 2026-04-30 | Buy |
| AstaTech | 56035 | 2-AMINO-3-CYANO-4,5-DIMETHYLPYRROLE 98% | 21392-51-8 | 25G | $93 | 2026-04-30 | Buy |
| Activate Scientific | AS38138 | 2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile 95% | 21392-51-8 | 1g | $22 | 2026-06-04 | Buy |
| Activate Scientific | AS38138 | 2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile 95% | 21392-51-8 | 5g | $37 | 2026-06-04 | Buy |
| Activate Scientific | AS38138 | 2-Amino-4,5-dimethyl-1H-pyrrole-3-carbonitrile 95% | 21392-51-8 | 25g | $123 | 2026-06-04 | Buy |
2-Amino-3-cyano-4,5-dimethylpyrrole Chemical Properties, Uses, Production
Synthesis
6628-81-5
109-77-3
21392-51-8
A mixture of acetic anhydride (16.9 g, 165 mmol), acetic acid (2.26 g, 37.6 mmol), triethylamine (19 g, 188 mmol), and 4-(dimethylamino)pyridine (0.1 g, 0.75 mmol) was added to a reaction flask and heated to 50 °C. Racemic alanine (6.79 g, 76.2 mmol) was added in small batches over a period of 4 h under stirring while maintaining the reaction temperature in the range of 45-55 °C. The reaction was carried out at a constant temperature in the range of 45-55 °C. The reaction temperature was kept at a constant temperature in the range of 45-55 °C. After the alanine addition was completed, the red mixture was continued to be stirred at 50 °C for 8 hours. Subsequently, acetic anhydride, acetic acid and triethylamine were removed by vacuum distillation (15-20 mbar) and the temperature of the system was gradually raised to a maximum of 100 °C. The residue of the resulting acylamino ketone intermediate (246) was cooled to room temperature and water (40 mL) was added. Next, malononitrile (4.71 g, 71.3 mmol) was added and the reaction mixture was slowly poured into 30% aqueous sodium hydroxide solution (25 mL), ensuring that the reaction temperature did not exceed 60 °C. The resulting mixture was cooled to 0 °C, filtered, washed with water (45 mL), and dried under vacuum to give 6.65 g of pyrrole derivative (7) in beige solid form in 66% yield; the melting point was 163-165 °C (literature value) [24].
References
[1] Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990, vol. 29, # 1, p. 47 - 52
[2] Bioorganic Chemistry, 2018, vol. 81, p. 612 - 629
[3] Pharmazie, 1989, vol. 44, # 12, p. 814 - 816
[4] Chimia, 2004, vol. 58, # 9, p. 640 - 648
[5] Organic Process Research and Development, 2001, vol. 5, # 6, p. 581 - 586
2-Amino-3-cyano-4,5-dimethylpyrrole Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Suzhou Sibian Chemical Technology Co.,Ltd. | 0512-65617459 18915409046 | sales@sibian-chem.com | China | 1917 | 55 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
View Latest Price from 2-Amino-3-cyano-4,5-dimethylpyrrole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | 2-Amino-3-cyano-4,5-dimethylpyrrole
21392-51-8
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2020-01-01 | 2-Amino-3-cyano-4,5-dimethylpyrrole
21392-51-8
|
$1.00 | 1KG | 99% | 500kg | Career Henan Chemical Co |
-
- 2-Amino-3-cyano-4,5-dimethylpyrrole
21392-51-8
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 2-Amino-3-cyano-4,5-dimethylpyrrole
21392-51-8
- $1.00
- 99%
- Career Henan Chemical Co
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